Estimating The Efficiency Of Phagocytic Neutrophil Cells And Studying Its Risk Factors Among Diabetic Foot Ulcers

Abstract

There are several factors that affect the efficiency of phagocytic activity in diabetic patients. In this study, a significant difference of phagocytosis efficiency showed in diabetic patients and controls (non-diabetic). The means of phagocytic activity were 43.05%, 52.70% and 71.35% for diabetic foot ulcer, diabetes mellitus patients and controls respectively. Age groups, mean blood glucose levels and controlling fasting blood glucose were significant factors effects on phagocytic activity (P-value = 0.022, 0.013 and 0.045) respectively. There was reverse significant correlation between the mean blood glucose and phagocytic activity (P-value = 0.049; r =-0.314). Wagner grade ulcers classified I and II were the most prevalent 30% for both in diabetic foot ulcer patients. And we found that there is a weak negative correlation between the phagocytic activity efficiency and the grades of the classified ulcers (r =-0.323). In this study, we revealed that the efficiency of phagocytic activity was affected by many factors. Level of blood glucose control was the most important factor.

Emergence of K1 ST23 and K2 ST65 hypervirulent klebsiella pneumoniae as true pathogens with specific virulence genes in cryptogenic pyogenic liver abscesses Shiraz Iran

“…In our study, no metastatic infection with the source of PLA was found in patients with hypervirulent K. pneumoniae- related pyogenic liver abscess, whereas this phenomenon has been reported in previous studies ( Fung et al., 2002 ; Tan et al., 2004 ; Sun et al., 2021 ). Diabetes is a known predisposing factor for impaired neutrophil chemotaxis and phagocytosis ( Baras and Bin-Hameed, 2021 ). Patients with metastatic infections are usually diabetic, but some of them with metastatic infections by hvKp strains are healthy and have no history of diabetes, so another important factor may be involved in this phenomenon.…”

A Survey on Impact of Internet of Medical Things Against Diabetic Foot Ulcer

“…Detailed analyses of ulcer characteristics, such as stages and phagocytic movement efficiency, are contributing to the field. Researchers also explore innovative treatments, including hyperbaric oxygen therapy and placental-derived products, to address challenges like polymicrobial infections [4].…”