Estimating the joint effect of diabetes and subsequent depressive symptoms on mortality among older latinos

Inoue, Kosuke; Mayeda, Elizabeth Rose; Nianogo, Roch A.; Paul, Kimberly C.; Yu, Yu; Haan, Mary N.; Ritz, Beate

doi:10.1016/j.annepidem.2021.09.007

Cited by 6 publications

(7 citation statements)

References 45 publications

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“…Strengths and weaknesses in relation to other studies Our findings are in keeping with previous studies reporting a high risk of all-cause and circulatory mortality risk among people with comorbid depression and diabetes that exceeds the risk due to having either diabetes or depression alone [13,[16][17][18][19][20][21]. While the strengths of the associations between comorbid depression and diabetes and risk of all-cause and circulatory mortality were similar in some previous studies [17][18][19]21], others observed much higher HRs of 3.64 [20], 3.71 [13] and 4.56 [16] for risk of all-cause mortality and 3.27 for circulatory mortality risk [17]. Potential explanations for the observed differences are the use of very selected reference groups, such as people with a score of 0 on the Centre for Epidemiologic Studies of Depression Scale [13,16], and differences in the study populations [17,20].…”

Section: Discussionsupporting

confidence: 86%

“…Furthermore, future studies should attempt to identify mechanisms that may be responsible for the synergistic effect of depression and diabetes on risk of mortality in order to inform the development and testing of interventions. Finally, the temporality of depression and diabetes deserves further attention, with one recent study suggesting smaller joint effects of depression and diabetes when both disorders are ascertained at the same point in time than when depressive symptoms develop after diagnosis of diabetes [18].…”

Section: Discussionmentioning

confidence: 99%

“…There is some evidence that the association between depression and risk of all-cause mortality may be more pronounced among individuals with type 1 or type 2 diabetes than among those without [13][14][15], but few studies have investigated the individual and joint effects of depression and diabetes on mortality risk [13,[16][17][18][19][20][21]. These studies have consistently reported that people with comorbid depression and diabetes are at particularly high risk of all-cause and cardiac mortality.…”

Section: Introductionmentioning

confidence: 99%

“…None of the existing studies in the general population has investigated causes of death other than circulatory disease, despite evidence that depression may be linked to an increased risk of noncardiovascular, non-cancer mortality in patients with diabetes [22]. Furthermore, existing studies are largely based on samples from the USA [16,[18][19][20][21], are limited by small sample sizes [16][17][18] or are based on selected patient populations, such as patients hospitalised for myocardial infarction [17,20].…”

Section: Introductionmentioning

confidence: 99%

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Depression, diabetes, comorbid depression and diabetes and risk of all-cause and cause-specific mortality: a prospective cohort study

2022

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Aims/hypothesis The aim of this study was to investigate the risks of all-cause and cause-specific mortality among participants with neither, one or both of diabetes and depression in a large prospective cohort study in the UK. Methods Our study population included 499,830 UK Biobank participants without schizophrenia and bipolar disorder at baseline. Type 1 and type 2 diabetes and depression were identified using self-reported diagnoses, prescribed medication and hospital records. Mortality was identified from death records using the primary cause of death to define cause-specific mortality. We performed Cox proportional hazards models to estimate the risk of all-cause mortality and mortality from cancer, circulatory disease and causes of death other than circulatory disease or cancer among participants with either depression (n=41,791) or diabetes (n=22,677) alone and with comorbid diabetes and depression (n=3597) compared with the group with neither condition (n=431,765), adjusting for sociodemographic and lifestyle factors, comorbidities and history of CVD or cancer. We also investigated the interaction between diabetes and depression. Results During a median of 6.8 (IQR 6.1–7.5) years of follow-up, there were 13,724 deaths (cancer, n=7976; circulatory disease, n=2827; other causes, n=2921). Adjusted HRs of all-cause mortality and mortality from cancer, circulatory disease and other causes were highest among people with comorbid depression and diabetes (HRs 2.16 [95% CI 1.94, 2.42]; 1.62 [95% CI 1.35, 1.93]; 2.22 [95% CI 1.80, 2.73]; and 3.60 [95% CI 2.93, 4.42], respectively). The risks of all-cause, cancer and other mortality among those with comorbid depression and diabetes exceeded the sum of the risks due to diabetes and depression alone. Conclusions/interpretation We confirmed that depression and diabetes individually are associated with an increased mortality risk and also identified that comorbid depression and diabetes have synergistic effects on the risk of all-cause mortality that are largely driven by deaths from cancer and causes other than circulatory disease and cancer. Graphical abstract

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Depression, diabetes, comorbid depression and diabetes and risk of all-cause and cause-specific mortality: a prospective cohort study

2022

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“…The results of a meta-analysis ( 4 ) showed that patients with T2DM and comorbid depression had a 47.9% increase in cardiovascular mortality compared to patients with T2DM alone. A follow-up study of 1,495 patients over a median follow-up period of 7.7 years showed that patients with diabetes and depressive symptoms 1 year after enrollment were associated with increased eventual cardiovascular mortality ( 16 ).…”

Section: Comorbidity Characteristicsmentioning

confidence: 99%

Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease

Zhu

Luo

et al. 2022

Front. Cardiovasc. Med.

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Depression is a common comorbidity of type 2 diabetes mellitus (T2DM). T2DM with comorbid depression increases the risk of cardiovascular events and death. Depression and T2DM and its macrovascular complications exhibited a two-way relationship. Regarding treatment, antidepressants can affect the development of T2DM and cardiovascular events, and hypoglycemic drugs can also affect the development of depression and cardiovascular events. The combination of these two types of medications may increase the risk of the first myocardial infarction. Herein, we review the latest research progress in the exacerbation of cardiovascular disease due to T2DM with comorbid depression and provide a rationale and an outlook for the prevention and treatment of cardiovascular disease in T2DM with comorbid depression.

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Depressive symptoms decrease health-related quality of life of patients with coronary artery disease and diabetes: a 12-month follow up study in primary care

Tusa

Kautiainen

Elfving

et al. 2023

Scandinavian Journal of Primary Health Care

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Objective Health-related quality of life (HRQoL) is a multidimensional patient-related outcome. Less is known about the role of depressive symptoms on HRQoL in chronic diseases. This follow-up study analyzed depressive symptoms’ association with HRQoL change measured with 15D in patients with chronic diseases. Design and setting A total of 587 patients from the Siilinjärvi Health Center, Finland were followed up due to the treatment of hypertension (HA), coronary artery disease (CAD) or diabetes (DM). Depressive symptoms were based on Beck Depression Inventory (BDI) (BDI ≥10 =depressive symptoms). HRQoL was assessed at the baseline and after 12 months. Results There were 244 patients with HA (mean age 70 years, 59% women); 103 patients (72 years, 38%) with CAD and 240 with DM (67 years, 52%). The change from baseline to the 12-month follow-up in 15D was significantly different between patients without and with depressive symptoms in CAD ( p < 0.001) and DM ( p = 0.024). In CAD with depressive symptoms, the change was −0.064 (95% CI: −0.094 to −0.035) and in DM −0.018 (95% CI: −0.037 to 0.001). In the 15 HRQoL dimensions of 15D, a depressive symptoms-related decrease was found in three dimensions with HA, in 9 with CAD and in 7 with DM. As a function of the BDI at baseline, the 15D score decreased significantly among patients with CAD and DM. Conclusions Depressive symptoms impact negatively on future HRQoL among primary care patients with coronary artery disease and diabetes emphasizing that mood should be acknowledged in their care and follow-up. Trial registration Clinical Trials registration number: NCT02992431, registered December 14 th 2016

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Estimating the joint effect of diabetes and subsequent depressive symptoms on mortality among older latinos

Cited by 6 publications

References 45 publications

Depression, diabetes, comorbid depression and diabetes and risk of all-cause and cause-specific mortality: a prospective cohort study

Depression, diabetes, comorbid depression and diabetes and risk of all-cause and cause-specific mortality: a prospective cohort study

Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease

Depressive symptoms decrease health-related quality of life of patients with coronary artery disease and diabetes: a 12-month follow up study in primary care

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