Estimating the Occurrence of Renal Complications Among Persons With Ankylosing Spondylitis

Levy, Adrian R.; Szabo, Shelagh M.; Rao, Sumati; Cifaldi, M.; Maksymowych, Walter P.

doi:10.1002/acr.22176

Cited by 40 publications

(25 citation statements)

References 19 publications

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“…In a population-based, retrospective cohort study, renal complications in the male and female patients with AS were reported as 3.4% and 2.1%, respectively. [22] In the aforementioned study, the ratio of renal complications was suggested more than 72% in AS patients, compared to the normal population.…”

Section: Discussionmentioning

confidence: 93%

The prevalence of comorbidity and predictors in ankylosing spondylitis

Gökşenoğlu¹,

Buğdaycı²,

Paker³

et al. 2019

Turk J Phys Med Rehab

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Objectives: The aim of the present study was to investigate the prevalence of comorbidities and related factors in patients with ankylosing spondylitis (AS). Patients and methods: Between June 2013 and January 2014, a total of 100 patients with AS (64 males, 36 females; mean age 43.1±10.7 years; range, 25 to 73 years) who were under routine follow-up in the outpatient clinic were included in this cross-sectional study. The demographic characteristics of the patients were recorded. The Ankylosing Spondylitis Disease Activity Scale (ASDAS), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Bath Ankylosing Spondylitis Metrology Index (BASMI) scores were calculated. Comorbidities were evaluated using the modified Cumulative Illness Rating Scale (CIRS). Both the number and severity of the affected systems were scored. Results: The mean amount of cigarette consumption was 17.3±13.5 pack/year. The mean disease duration was 191.3±122.4 months. The BASFI, BASDAI, BASMI, and ASDAS-C-reactive protein scores were 3.4±2.3, 3.7±2.0, 4.5±1.8, and 2.5±0.9, respectively. The mean number of system-related problems was 4.3 (range, 1 to 11). The mean CIRS scores for the severity of comorbidities were 7.36±3.48 (range, 3 to 23). The most frequent system combinations were hematopoietic, eye, ear, nose and throat, and upper gastrointestinal in 11 patients, hematopoietic, respiratory and upper gastrointestinal in 11 patients, and hematopoietic, respiratory and eye, ear, nose and throat in 10 patients. When the estimated total CIRS scores was assessed in the multivariate reduced model, age, disease duration, and BASFI values showed a significant independent effect. Conclusion: Our study results showed that the frequency of comorbidities was more than four, although the severity of system problems were mild in AS patients as measured by CIRS. The most frequently involved systems included hematopoietic, upper gastrointestinal, lower gastrointestinal, renal, and musculoskeletal-skin systems. Age, disease duration, and BASFI scores were found to be predictors of comorbidities in our patients.

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Section: Discussionmentioning

confidence: 93%

The prevalence of comorbidity and predictors in ankylosing spondylitis

Gökşenoğlu¹,

Buğdaycı²,

Paker³

et al. 2019

Turk J Phys Med Rehab

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“…The prevalence of a reduced glomerular filtration rate (<60) was 16% among patients with 'seronegative arthritis' (which included patients with PsA), similar to RA [106,107]. The prevalence of a reduced glomerular filtration rate (<60) was 16% among patients with 'seronegative arthritis' (which included patients with PsA), similar to RA [106,107].…”

Section: Kidney Diseasementioning

confidence: 90%

Recognizing and managing comorbidities in psoriatic arthritis

Ogdie

Schwartzman

Husni

2015

Current Opinion in Rheumatology

156

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“…On the other hand, it demonstrates the cause of IgA nephropathy in AS patients. Previous studies have shown that IgA nephropathy is most commonly found in renal involvement in AS, and accounts for about 30% [27]. Serotype IgA is associated with elevated secretion of IgA, whereas secretory IgA is the major antibody found in the secretory fluid, which is involved in local mucosal protection.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Renal Involvement Based on Different Manifestations in Patients with Ankylosing Spondylitis

Zhang

Wang

et al. 2018

Kidney Blood Press Res

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Background/Aims: Renal involvement is one of the most common extra-articular complications caused by ankylosing spondylitis (AS). Most studies have focused on the incidence rate, clinical manifestation and pathology, while risk factors have hardly been investigated. Therefore, the objective of this study was to assess the risk factors of renal involvement in patients with AS. Methods: Clinical and biochemical data of 926 AS patients were collected. Based on the manifestations of renal involvement, patients were divided into three groups and the differences in clinical and biochemical characteristics were compared. A group with non-renal involvement served as a control. Multivariable logistic regression was used for analyzing risk factors of renal involvement in AS. Results: Of the 926 AS patients, 201 patients suffered from renal involvement. Moreover, female AS patients faced a higher risk of hematuria compared to male patients. As indicated by the data obtained from multivariate logistic regression analysis, gender, uric acid (UA), immunoglobulin A (IgA), and serum albumin (ALB) were found to be risk factors of renal involvement in AS. An increase in UA or IgA levels, or a decrease in ALB level can increase the risk of renal involvement with multiple manifestations (more than one manifestation of renal damage). According to our findings, no definite variable was identified as a risk factor of proteinuria in AS patients. Conclusion: In AS patients, UA, IgA, and ALB levels can indicate the risk of renal involvement in AS patient and need to be paid special attention. Furthermore, women are subjected to a higher risk of hematuria.

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Estimating the Occurrence of Renal Complications Among Persons With Ankylosing Spondylitis

Cited by 40 publications

References 19 publications

The prevalence of comorbidity and predictors in ankylosing spondylitis

The prevalence of comorbidity and predictors in ankylosing spondylitis

Recognizing and managing comorbidities in psoriatic arthritis

Risk Factors of Renal Involvement Based on Different Manifestations in Patients with Ankylosing Spondylitis

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