Estimating the prevalence among Caucasian women of primary Sjögren's syndrome in two general practices in Birmingham, UK

Abstract

Our data support previous studies suggesting a prevalence of PSS in the community of 0.1-0.6% rather than those suggesting a higher figure.

Prevalence and incidence in patients with autoimmune rheumatic diseases: A nationwide population‐based study in Taiwan

“…In a study from China (34), the prevalence rate was 0.77% when the Copenhagen criteria were used and 0.33% when the San Diego criteria were used. In the present study, the prevalence of primary Sjö gren's syndrome was 0.016%, which is lower than those reported in whites (32,33). The SMR of Sjö gren's syndrome was reported to be 1.02-2.07 (35), which is similar to that found in the present study (1.3).…”

“…The prevalence of Sjö gren's syndrome among women from 2 primary care practices in the UK ranged from Ͻ0.1% to 0.4% (32). In a population-based study from Olmsted County, Minnesota, the average annual age-and sex-adjusted incidence of physician-diagnosed Sjö gren's syndrome was estimated to be 3.9 (95% CI 2.8 -4.9) per 100,000 populations (33).…”

204. A Systematic Review of Non-Pharmacological Interventions for Primary Sjögren’s Syndrome

“…Consequently, many patients experience reduced quality of life and difficulty with carrying out a range of daily activities [14,15]. Furthermore, the disease is associated with significant direct and indirect healthcare costs equating to £12 15 000 per patient, per year [16,17]. Similar figures have been identified in the USA [18].…”

A-fodrinAutoantigen Detection in Saliva and on Salivary Ductal Cells in Sjögren Syndrome

“…Sjögren syndrome is an autoimmune disease, producing a range of autoantibodiesand cytokines leading to apoptosis of salivary and lacrimal tissues [1][2][3][4][5]. Current diagnostic tests are unable to render a specific diagnosis of SS and thus there is a need for improved diagnostic tools.…”

“…We have shown this in the case of Sjögren syndrome type A (SS-A) and B (SS-B) antigens as well as cleaved α-fodrin [7,8]in vitro. In vivo, such autoantigens could elicit autoantibody production and contribute to the initiation and propagation of autoimmunity [3].Because apoptosis is a well-documented mechanism leading to salivary cell death, we hypothesized that the apoptotic products of salivary tissues may be detectable in the saliva of patients with SS. In patients with HIV/AIDS, the retrovirus or products also induces apoptosis, and patients may also suffer xerostomia due to diffuse infiltrative lymphocytosis syndrome (DILS).…”