Estimating the whole-body effective dose and health risks as well as introducing a new easy method for eye lens dosimetry in interventional cardiology procedures

Hatami, Alireza; Bagheri, Mohsen; Falahati, Farzaneh; Banaei, Amin; Abedi-Firouzjah, Razzagh; Zamani, Hossein; Kiapour, Mohammad; Momeni, Fatemeh

doi:10.1016/j.mex.2020.101097

Cited by 1 publication

(1 citation statement)

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“…Hatami et al ( 62 ) and Miyaji et al ( 63 ) compared the eye lens and whole-body dose measured by several dosimetric technologies for medical-related radiation exposures. The former study was in relation to interventional cardiology and compared the doses to physicians delivered to thermoluminescent dosimeters (TLDs) positioned in the vicinity of the eyes and to TLDs placed in the vicinity of the chest.…”

Section: Discussionmentioning

confidence: 99%

Electron, Photon, and Neutron Dose Conversion Coefficients of Lens and Non-Lens Tissues Using a Multi-Tissue Eye Model to Assess Risk of Cataracts and Retinitis

Ali

Richardson

2023

Radiation Research

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Previous publications describe the estimation of the dose from ionizing radiation to the whole lens or parts of it but have not considered other eye tissues that are implicated in cataract development; this is especially critical for low-dose, low-ionizing-density exposures. A recent review of the biological mechanisms of radiation-induced cataracts showed that lenticular oxidative stress can be increased by inflammation and vascular damage to non-lens tissues in the eye. Also, the radiation oxygen effect indicates different radiosensitivities for the vascular retina and the severely hypoxic lens. Therefore, this study uses the Monte Carlo N-Particle simulations to quantify dose conversion coefficients for several eye tissues for incident antero-posterior exposure to electrons, photons, and neutrons (and the tertiary electron component of neutron exposure). A stylized, multi-tissue eye model was developed by modifying a model by Behrens etal. (2009) to include the retina, uvea, sclera, and lens epithelial cell populations. Electron exposures were simulated as a single eye, whereas photon and neutron exposures were simulated employing two eyes embedded in the ADAM-EVA phantom. For electrons and photons, dose conversion coefficients are highest for either anterior tissues for low-energy incident particles or posterior tissues for high-energy incident particles. Neutron dose conversion coefficients generally increase with increasing incident energy for all tissues. The ratio of the absorbed dose delivered to each tissue to the absorbed dose delivered to the whole lens demonstrated the considerable deviation of non-lens tissue doses from lens doses, depending on particle type and its energy. These simulations demonstrate that there are large variations in the dose to various ocular tissues depending on the incident radiation dose coefficients; this large variation will potentially impact cataract development.

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Section: Discussionmentioning

confidence: 99%