Estimation and Comparison of Serum and Salivary IgA Levels in Controlled, Uncontrolled Diabetics and Normal Individuals

Bhuyan, Sanat Kumar; Mody, RN; Bhuyan, Ruchi; Kailasam, S

doi:10.5005/jp-journals-10011-1220

Cited by 5 publications

(7 citation statements)

References 11 publications

(12 reference statements)

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“…Previous studies have been investigated the association of salivary components, such as Ig-A, with different oral conditions [3, 6, 8, 35]. In the current study, uncontrolled diabetic patients with oral candidiasis, white plaque, abscesses, or xerostomia had higher s-IgA levels compared to the controlled diabetic participants; however, no significant differences were observed between the uncontrolled diabetic patients and the healthy participants.…”

Section: Discussioncontrasting

confidence: 48%

“…Conversely, Salles et al [34] reported a lower s-IgA concentration in diabetic patients compared to non-diabetic individuals, which is probably related to the non-homogeneous gender distribution and the use of both T1DM and T2DM patients in their research. Another study conducted by Bhuyan et al [35] demonstrated lower level of s-IgA in diabetic patient’s specially uncontrolled diabetic ones. Moreover, others found no significant differences [5, 28, 36].…”

Section: Discussionmentioning

confidence: 98%

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Association of salivary levels of immunoglobulin-a and amylase with oral-dental manifestations in patients with controlled and non-controlled type 2 diabetes

et al. 2019

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Background Oral health is related to general health and one of the most prevalent chronic diseases is diabetes mellitus. Diabetes can have adverse effects on oral health and vice versa. Saliva analysis can be used as a non-invasive method to obtain information about diseases status like diabetes. The aim of present study was to evaluate the salivary immunoglobulin-A (s-IgA) and salivary amylase levels and their associations with oral-dental manifestations in patients with controlled and non-controlled type 2 diabetes. Methods This case-control study was carried out on 90 subjects who referred to the Diabetes Center of Shahid Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran. Participants were divided into three groups: 1) uncontrolled diabetic patients ( n = 30); 2) controlled diabetic patients ( n = 30); and 3) healthy individuals ( n = 30). Unstimulated salivary levels of I-A and amylase were measured. All participants underwent a dental and periodontal examination to explore the oral and dental manifestations. T-test, chi-square and ANOVA tests were used for data analysis in SPSS 18. Results Significant higher level of s-IgA was found in uncontrolled diabetic patients compared to controlled diabetic ( P ≤ 0.0001) and the control group ( P = 0.004). Moreover, the mean levels of s-amylase in uncontrolled patients was significantly higher compared to controlled diabetic ( P = 0.01) and the control group (P ≤ 0.0001). Uncontrolled diabetic patients with oral candidiasis, erythematous candidiasis, abscesses, or xerostomia had higher s-IgA levels compared to the controlled diabetic participants. Moreover, uncontrolled diabetic patients with oral candidiasis or erythematous candidiasis showed a significant higher levels of s-amylase compared to controlled diabetic patients. Also, significant positive correlations were found between s-IgA and DMFT and s-IgA and PDI (r = 0.444, P = 0.014 and r = 0.386, P = 0.035, respectively). Conclusion In conclusion, higher s-amylase and s-IgA concentrations may reflect oral-dental manifestations in T2DM. Moreover, the current findings suggest that s-amylase and s-IgA may serve as a complementary and alternative fluid in screening for diabetes mellitus.

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Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 98%

Association of salivary levels of immunoglobulin-a and amylase with oral-dental manifestations in patients with controlled and non-controlled type 2 diabetes

et al. 2019

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“…Although, some studies showed higher rate of IgA deficiency in diabetic patients [ 2 , 18 ], in our study the frequency of selective IgA deficiency in patient and control groups was similar. Genetic susceptibility and ethnic background or the method of selection or sampling of study population might be explained these differences.…”

Section: Discussionsupporting

confidence: 46%

“…Although, several studies showed an elevated mean of serum IgA concentration in type 1 and type2 diabetic patients specially for those with complications compared to controls. [ 18 – 22 ] in our study the mean of serum IgA concentration in diabetics was lower than control. Absence of infection, complications or other autoimmune disorders in our patients could be explained this contrary result.…”

Section: Discussionsupporting

confidence: 38%

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Evaluation of Serum & Salivary IgA in Patients with Type 1 Diabetes

2015

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BackgroundDiabetes mellitus is a common immune mediated disorder. The aim of the present study is to evaluate the level of serum and salivary IgA levels in patients with Type 1 diabetes.Material and MethodIn this case control study, serum and salivary IgA levels of patients with diabetes type 1 and similar non diabetes subjects were measured. Age, gender, duration of diabetes and the last HbA1c level of diabetic patients were also studied. Data was analyzed by SPSS software.ResultsTwo hundred and fifty subjects (126 diabetics and 124 non diabetics) were enrolled in the study. The mean value of serum IgA in patients with Type 1 Diabetes and controls was 1.77± 1.55 g/lit and 2.39± 1.52 g/lit, respectively. The mean salivary IgA level in diabetics and controls was 276 ± 162.5 40 μg/ml and 129 ± 112.2 40 μg/ml, respectively. Selective IgA deficiency was detected in two (1.6%) and three(2.4%)cases of diabetic and control group; respectively (p=0.68). We found low salivary IgA level in 44.4% diabetic and 33.9% control (p=0.08). There was no significant correlation between serum and salivary IgA level. There was also significant association between serum IgA levels with age. Salivary IgA was significantly correlated with HbA1c level. But considering gender, duration of diabetes we didn’t find any association.ConclusionWe didn't find any significant difference in serum and salivary IgA level among diabetic and non diabetics and also, no association between serum and salivary IgA levels.

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Values of Serum C-Reactive Protein and Salivary Immunoglobulin Iga in Diabetic Patients: Relation to the Severity of Periodontal Disease

Omer

Abdullah

Al-Naemi

2020

dmj

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Background: Altered immune response and improper neutrophils chemotaxis, phagocytosis, and adhesion might be the principal causative factor for increased susceptibility to periodontal pathogens and oral complications in diabetic patients. This study aimed to determine the relationship between C-reactive protein and salivary IgA with periodontal disease and the severity of dental caries with the glycemic control state of patients with diabetes mellitus. Patients and Methods: This study was carried out on 91 subjects, 61 patients with diabetes mellitus, and 30 apparently healthy subjects (as a control group). The patient groups were regularly attended Duhok Diabetes Center, Duhok City, Kurdistan Region (Iraq) for diabetes management. The healthy controls were recruited from the staff and sub staff of Azadi Teaching Hospital. Fasting plasma glucose, HbA1c, and serum high sensitivity C-reactive protein (Hs-CRP) were measured. The whole saliva collection was performed by an unstimulated method for five minutes in a graduated test tube to recognize the salivary secretion rate and then stored at -20 0 C for IgA estimation. Periodontal Index was used to determine the periodontal disease status. Each tooth was scored according to the condition of the surrounding tissues. Results: Significantly higher Hs-CRP (9.2 vs 3.3 µg/ml), fasting plasma glucose (215.4 vs 98.9 mg/dl) and HbA1c (8.5 vs 4.9 %), (P < 0.001 for all parameters, together with lower hemoglobin (13.6 vs 14.5 gm/dl, P=0.03) levels were found in diabetic patients compared to control group, A significantly higher mean salivary IgA level in diabetic patients compared to controls (312.4 vs 177.3 mg/dl, P<0.001), associated with a significant high periodontal index (1.68 vs 0.81, P = 0.003). Conclusion: Elevated serum Hs-CRP and salivary IgA in patients with diabetes mellitus as inflammatory response sequences raise inflammation potential in the periodontium. Further, the results confirm that periodontal index was associated with poor glycemic control.

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Estimation and Comparison of Serum and Salivary IgA Levels in Controlled, Uncontrolled Diabetics and Normal Individuals

Cited by 5 publications

References 11 publications

Association of salivary levels of immunoglobulin-a and amylase with oral-dental manifestations in patients with controlled and non-controlled type 2 diabetes

Association of salivary levels of immunoglobulin-a and amylase with oral-dental manifestations in patients with controlled and non-controlled type 2 diabetes

Evaluation of Serum & Salivary IgA in Patients with Type 1 Diabetes

Values of Serum C-Reactive Protein and Salivary Immunoglobulin Iga in Diabetic Patients: Relation to the Severity of Periodontal Disease

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