Estimation and validation of mercury intake associated with fish consumption in an EPIC cohort of Spain

Sanzo, J M; Dorronsoro, Miren; Amiano, Pilar; Amurrio, Ascensión; Aguinagalde, FX; Azpiri, MA

doi:10.1079/phn2001170

Cited by 60 publications

(49 citation statements)

References 37 publications

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“…The correlation coefficients of the estimated values for T-Hg in RBC and hair were 0?325 (P , 0?0001) and 0?305 (P , 0?0001), respectively. In other studies, Sanzo et al (29) reported that the correlation coefficient between T-Hg intake and T-Hg in RBC for 120 individuals in Spain was 0?36 (P , 0?005), Iwasaki et al (30) reported one of 0?335 (P , 0?001) between T-Hg intake and T-Hg in hair for 154 Japanese women, and Ohno et al (31) reported a correlation coefficient of 0?551 (P , 0?01) between T-Hg intake and T-Hg in hair for fiftynine Japanese women. Although the sample sizes and significance levels were different among studies, our result of 'about 0?3' was similar to the former two studies.…”

Section: Discussionmentioning

confidence: 82%

Assessment of exposure to methylmercury in pregnant Japanese women by FFQ

Yaginuma-Sakurai

Shimada

Ohba

et al. 2009

Public Health Nutr.

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Objective: To examine whether an FFQ can be used for assessing exposure to methylmercury (MeHg) by estimating MeHg intake from seafood consumption using the FFQ and confirming the accuracy of the estimated value. Design: Seafood consumption of pregnant women was assessed using the FFQ. Total mercury (T-Hg) concentrations of maternal red blood cells (RBC) and hair were measured as exposure indices of MeHg. Setting: A prospective birth cohort study, the Tohoku Study of Child Development (TSCD), which has been ongoing since 2001. Subjects: The subjects were 609 pregnant Japanese women who were enrolled in the TSCD. Results: MeHg intake was estimated from seafood consumption determined using the FFQ and the MeHg concentrations in each type of seafood. The accuracy of the estimated value was confirmed by comparison with T-Hg in RBC and hair. Estimated MeHg intake was 42?3 mg/week, and 43?0 % of that was from large predatory fish. Compared with the Japanese tolerable weekly intake, in total 12?5 % of the subjects exceeded it. T-Hg concentrations in RBC and hair were significantly correlated with estimated MeHg intake: r 5 0?325 (P , 0?0001) for RBC and r 5 0?305 (P , 0?0001) for hair. Conclusions: Estimated MeHg intake based on the FFQ was significantly associated with T-Hg concentrations in RBC and hair. Although the estimated value involves uncertainties, the FFQ appears to be a useful tool for assessment of exposure to MeHg.

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Section: Discussionmentioning

confidence: 82%

Assessment of exposure to methylmercury in pregnant Japanese women by FFQ

Yaginuma-Sakurai

Shimada

Ohba

et al. 2009

Public Health Nutr.

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“…Published data suggest that MeHg levels in fish from Spain are somewhat higher than those in the USA or UK, where previous studies were conducted (e.g. 0?32-0?48 v. 0?35-0?40 mg/g in tuna from Spain v. the USA and UK) (11,24,27,46,47) . Hair Hg levels in a random sub-sample of children from this cohort were somewhat higher than in US children (48) .…”

Section: Discussionmentioning

confidence: 95%

Maternal fish and other seafood intakes during pregnancy and child neurodevelopment at age 4 years

Mendez

Torrent

Júlvez

et al. 2009

Public Health Nutr.

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Objective: To analyse the relationship between maternal intakes of fish and other seafood during pregnancy and child neurodevelopment at age 4 years. Although pregnant women are advised to limit seafood intakes because of possible neurotoxin contamination, several studies suggest that overall maternal seafood intakes are associated with improved child neurodevelopment, perhaps because of higher DHA intakes. Design: The study uses data from a prospective birth cohort study. Maternal seafood intakes were assessed using a semi-quantitative FFQ administered shortly after delivery. Multivariate linear regression was used to estimate associations between seafood consumption and scores on the McCarthy Scales of Children's Abilities (MCSA). Analyses were stratified by breast-feeding duration as breast milk is a source of DHA during the postnatal phase of the brain growth spurt. Setting: Menorca, Spain, 1997-2001. Subjects: Full-term children (n 392) with data on maternal diet in pregnancy, breast-feeding duration and neurodevelopment at age 4 years. Results: Among children breast-fed for ,6 months, maternal fish intakes of .2-3 times/week were associated with significantly higher scores on several MCSA subscales compared with intakes #1 time/week. There was no association among children breast-fed for longer periods. Maternal intakes of other seafood (shellfish/squid) were, however, inversely associated with scores on several subscales, regardless of breast-feeding duration.Conclusions: The study suggests that moderately high intakes of fish, but not other seafood, during pregnancy may be beneficial for neurodevelopment among children breast-fed for ,6 months. Further research in other populations with high seafood intakes and data on additional potential confounders are needed to confirm this finding.

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“…Discrepancies between modeled intakes and questionnaire-based daily intakes could also be explained by the fact that, in the latter case, intakes are calculated on the basis of reported concentrations of Hg in different food items (Table 1) and not directly measured in the consumed seafood. Other studies provided Hg concentrations in seafood (Sanzo et al, 2001;Mahaffey, 2004;Mahaffey et al, 2004;Sirot et al, 2008) and these are in the same range as the ones used to estimate daily intakes in this study (Table 1); however, in the case of missing values for certain seafood items, an upper-bound level of previously reported Hg concentrations was used in our study, which although more conservative may have influenced the central tendency of questionnaire-based daily intakes. This is reflected by the low concordance (low Pearson's correlation coefficient) between daily intakes of MeHg from seafood estimated by questionnaire and those reconstructed from biomarker levels using a modeling approach.…”

Section: Discussionmentioning

confidence: 99%

Comparison of a toxicokinetic and a questionnaire-based approach to assess methylmercury intake in exposed individuals

Noisel

Bouchard

Carrier

et al. 2010

J Expo Sci Environ Epidemiol

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Methylmercury (MeHg) is a neurotoxic contaminant and one of the main sources of exposure in humans is seafood consumption. It is thus of interest to assess precisely MeHg exposure. The objective of this study was to estimate MeHg daily intake in exposed individuals using two different approaches, a food questionnaire and toxicokinetic modeling, and compare the complementary and use of each method. For this purpose, a group of 23 fishermen from northern Quebec provided blood and hair samples and answered a standard food questionnaire focusing on seafood consumption. A published and validated toxicokinetic model was then used to reconstruct MeHg daily intakes from mercury (Hg) measurements in biological samples. These intakes were compared to those estimated using a standard food questionnaire on seafood consumption. Daily intakes of MeHg from seafood (mean/median (range)) estimated from hair concentrations with the toxicokinetic-based approach were 6.1/5.2 (0.0-19) mg/day. These intake values were on average six times lower than those estimated using a food questionnaire, that is, 49/32 (7.2-163) mg/day. No correlation was found between the toxicokinetic-based and the questionnaire estimates of MeHg daily intakes. Most of the MeHg intakes estimated with the food questionnaire (21/23) exceeded the US EPA RfD of 0.1 mg/kg bw/day, whereas only a small proportion (6/23) of modeled estimates exceeded the RfD. This study shows that human health risk estimates strongly depend on the chosen approach.

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Estimation and validation of mercury intake associated with fish consumption in an EPIC cohort of Spain

Cited by 60 publications

References 37 publications

Assessment of exposure to methylmercury in pregnant Japanese women by FFQ

Assessment of exposure to methylmercury in pregnant Japanese women by FFQ

Maternal fish and other seafood intakes during pregnancy and child neurodevelopment at age 4 years

Comparison of a toxicokinetic and a questionnaire-based approach to assess methylmercury intake in exposed individuals

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