Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry

García-Cervera, Carles; Giner-Galvañ, Vicente; Wikman-Jorgensen, Philip; Laureiro, Jaime; Rubio‐Rivas, Manuel; Arena, Anthony Gurjian; Arnalich-Fernández, Francisco; Pérez, José Luis Beato; Núñez, Juan Antonio Vargas; Igual, Jesús Javier González; Díez-Manglano, Jesús; Bailón, Manuel Méndez; Blanco, Marı́a José; Castro, Santiago J. Freire; Lobo, Judit Aranda; Manzano, Luís; Gamboa, Jeffrey Oskar Magallanes; Pérez, Luis Arribas; Moraleja, Julio González; Hernáiz, Ruth Calderón; Alegría, Javier García; Noya, Amara González; Huelgas, Ricardo Gómez; Lumbreras, Carlos; Santos, Juan Miguel Antón

doi:10.1007/s11606-021-07017-8

Cited by 17 publications

(13 citation statements)

References 44 publications

(96 reference statements)

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“…There is a paucity of extensive studies with a large follow-up and detailed characterization of not only venous but also arterial TEs including the time of diagnosis, the specific incidence rate over the course of the pandemic, the implications for previous anticoagulant treatments, or the possible use of D-dimer levels as an accurate biomarker for the detection of TEs [ 20 ]. In addition, a description according to the geographical area could be of interest, with scarce studies in the Spanish population [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Full Characterization of Thrombotic Events in All Hospitalized COVID-19 Patients in a Spanish Tertiary Hospital during the First 18 Months of the Pandemic

Tamayo-Velasco

Bombín-Canal

Cebeira

et al. 2022

JCM

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The presence of a procoagulant state, COVID-19-related coagulopathy, and an increased rate of thrombotic events (TEs) is widely known about. However, descriptive studies are scarce. Here, we conducted a large retrospective study including 2894 hospitalized COVID-19 patients followed up during the first 18 months of the pandemic to completely characterize any TE. Major TEs showed a 3.45% incidence rate. TEs were associated with increased intubation/90-day mortality risk [OR = 1.71, 95% CI (1.12–2.61), p < 0.013]. Venous thrombotic events (VTEs) were more frequent than arterial thrombotic events (ATEs) (72% vs. 28%), associated with enhanced levels of D-dimer (cross-linked fibrin derivatives formed during thrombolysis), which were related to mortality but more useful for early detection of thrombosis. In this regard, D-dimer plasma levels above 2014 µg/mL at hospital admission identify TEs with 91% accuracy (AUC = 0.91, p < 0.001), rising to almost 95% (AUC = 0.94, p < 0.001) with a cut-off value of 2666 µg/mL in VTEs. Moreover, 41% of TEs occurred in patients receiving LMWH thromboprophylactic treatments in hospital or domiciliary therapies. SARS-CoV-2 infection along with a sedentary lifestyle derived from the confinement in 2020 could be more determinant than a procoagulant state in patients with risk factors for TEs. Furthermore, the normal results obtained from the thrombophilia study after the acute process are linked to this independent procoagulant state and to SARS-CoV-2-derived coagulopathy.

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Section: Introductionmentioning

confidence: 99%

Full Characterization of Thrombotic Events in All Hospitalized COVID-19 Patients in a Spanish Tertiary Hospital during the First 18 Months of the Pandemic

Tamayo-Velasco

Bombín-Canal

Cebeira

et al. 2022

JCM

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“…Patients with COVID-19 have high levels of D-dimer in absence of thrombosis; thus, a lower specificity as a predictor of thrombotic events is to be expected and it is necessary to search for a higher cut-off value. As in the work by Kampouri et al 27 , the data published in the SEMI-COVID-19 Registry reported that a cut-off point of >3,000 ng/mL was useful for predicting venous thromboembolism in these patients 36 .…”

Section: Discussionmentioning

confidence: 65%

Utility of probability scores for the diagnosis of pulmonary embolism in patients with SARS-CoV-2 infection: A systematic review

Franco-Moreno

Bustamante‐Fermosel

Ruiz-Giardín

et al. 2023

Revista Clínica Española (English Edition)

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“…We read with interest the article written by García-Cervera et al with the analysis of the SEMI-COVID-19 registry with the finding of an admission D-dimer > 3.0 μg/mL as a strong predictor for venous thromboembolism (VTE) in patients hospitalized with COVID-19. 1 The authors conclude and recommend that this cut-off value ought to prompt the consideration to screen for VTE and initiate full-dose anticoagulation.…”

Section: Ear Editormentioning

confidence: 93%

COVID-19 and Elevated D-Dimer: A Tale of Caution

2022

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Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry

Cited by 17 publications

References 44 publications

Full Characterization of Thrombotic Events in All Hospitalized COVID-19 Patients in a Spanish Tertiary Hospital during the First 18 Months of the Pandemic

Full Characterization of Thrombotic Events in All Hospitalized COVID-19 Patients in a Spanish Tertiary Hospital during the First 18 Months of the Pandemic

Utility of probability scores for the diagnosis of pulmonary embolism in patients with SARS-CoV-2 infection: A systematic review

COVID-19 and Elevated D-Dimer: A Tale of Caution

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