Estimation of antibody levels after COVID-19 vaccinations: Preliminary evidence for immune interoception

Dimitroff, Stephanie J.; Würfel, Lisa; Meier, Maria; Faig, Kelly E.; Benz, Annika B.E.; Denk, Bernadette; Bentele, Ulrike U.; Unternaehrer, Eva; Pruessner, Jens C.

doi:10.1016/j.biopsycho.2023.108636

Cited by 3 publications

(1 citation statement)

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“…The raised level of total antibody titer was found to be significantly higher in vaccinated people compared to nonvaccinated people who have recovered from SARS-CoV-2 infections. Several studies have reported a significant rise in serum levels of total antibodies postvaccination with Covishield™ in healthy individuals ( 20 , 21 ). Few studies reported a significant difference in antibody titer with disease severity among COVID-19 recovered patients ( 22 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

RBD mutations at the residues K417, E484, N501 reduced immunoreactivity with antisera from vaccinated and COVID-19 recovered patients

Gupta,

Meher,

Giri

et al. 2024

dti

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Introduction: It is unclear whether induced spike protein-specific antibodies due to infections with SARS-CoV-2 or to the prototypic Wuhan isolate-based vaccination can immune-react with the emerging variants of SARS-CoV-2. Aim/objectives: The main objective of the study was to measure the immunoreactivity of induced antibodies postvaccination with Covishield™ (ChAdOx1 nCoV-19 coronavirus vaccines) or infections with SARS-CoV-2 by using selected peptides of the spike protein of wild type and variants of SARS-CoV-2. Methodology: Thirty patients who had recovered from SARS-CoV-2 infections and 30 individuals vaccinated with both doses of Covishield™ were recruited for the study. Venous blood samples (5 mL) were collected at a single time point from patients within 3-4 weeks of recovery from SARS-CoV-2 infections or receiving both doses of Covishield™ vaccines. The serum levels of total immunoglobulin were measured in both study groups. A total of 12 peptides of 10 to 24 amino acids length spanning to the receptor-binding domain (RBD) of wild type of SARS-CoV-2 and their variants were synthesized. The serum levels of immune-reactive antibodies were measured using these peptides. Results: The serum levels of total antibodies were found to be significantly (p<0.001) higher in the vaccinated individuals as compared to COVID-19 recovered patients. Our study reported that the mutations in the RBD at the residues K417, E484, and N501 have been associated with reduced immunoreactivity with anti-sera of vaccinated people and COVID-19 recovered patients. Conclusion: The amino acid substitutions at the RBD of SARS-CoV-2 have been associated with a higher potential to escape the humoral immune response.

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Section: Discussionmentioning

confidence: 99%