Estimation of associations between 10 common gene polymorphisms and gastric cancer: evidence from a meta-analysis

Xie, Zongjing; Wang, Bingmei; Chai, Yongjie; Chen, Junyin

doi:10.1136/jclinpath-2019-206189

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…The latter, in turn, triggers an alternative complement activation pathway to recognize tumor cells. Of note, disease development is dependent on the MBL gene polymorphism, which likely affects the genetic predisposition to this type of cancer, although this was not confirmed by the meta-analysis 13 .…”

Section: The Role Of Mannose In Gastric Cancer Progressionmentioning

confidence: 85%

“…At the same time, Wang et al 12 did not detect a significant difference among the entire cohort of patients and donors in a study involving the MBL2 gene polymorphism in 388 patients with GC and 144 healthy donors in the Japanese population. Moreover, Xie et al 13 reported no association between the MBL gene polymorphism and GC in a meta-analysis of 43 published studies.…”

Section: The Role Of Mannose In Gastric Cancer Progressionmentioning

confidence: 99%

See 1 more Smart Citation

Innate IgM antibodies to mannose in patients with gastric cancer

Nikulin,

Shilova,

Lipatnikov

et al. 2023

Cancer Biol Med

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Section: The Role Of Mannose In Gastric Cancer Progressionmentioning

confidence: 85%

Section: The Role Of Mannose In Gastric Cancer Progressionmentioning

confidence: 99%

Innate IgM antibodies to mannose in patients with gastric cancer

Nikulin,

Shilova,

Lipatnikov

et al. 2023

Cancer Biol Med

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“…We confirmed the significance of the two SNPs previously reported, rs3765524 and rs2274223, and revealed another SNP in PLCE1 , rs3781264, through genotyping and logistic regression in this case-control study was associated with the GC risk. Abnet et al (2010) firstly used GWAS to identify those variants of PLCE1 had a significant correlation with GC in the Chinese Han population Until now, an increasing number of studies have identified a shared susceptibility locus in PLCE1 such as rs2274223 A > G and rs3765524 C > T for gastrointestinal cancer ( Abnet et al, 2010 ; Umar et al, 2013 ; Cui et al, 2014b ; Liu et al, 2014 ; Malik et al, 2014 ; Mocellin et al, 2015 ; He et al, 2016 ; Gu et al, 2018 ; Li et al, 2018 ; Liang et al, 2019 ; Xie et al, 2020 ), and the most reported SNP of PLCE1 was the former, but the conclusions lack consistency. A meta-analysis showed that PLCE1 rs2274223 polymorphism resulted in susceptibility to esophageal and GC in Asians ( Umar et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

PLCE1 Polymorphisms Are Associated With Gastric Cancer Risk: The Changes in Protein Spatial Structure May Play a Potential Role

Jia

Yang

et al. 2021

Front. Genet.

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BackgroundGastric cancer (GC) is one of the most significant health problems worldwide. Some studies have reported associations between Phospholipase C epsilon 1 (PLCE1) single-nucleotide polymorphisms (SNPs) and GC susceptibility, but its relationship with GC prognosis lacked exploration, and the specific mechanisms were not elaborated fully yet. This study aimed to further explore the possible mechanism of the association between PLCE1 polymorphisms and GC.Materials and MethodsA case-control study, including 588 GC patients and 703 healthy controls among the Chinese Han population, was performed to investigate the association between SNPs of PLCE1 and GC risk by logistic regression in multiple genetic models. The prognostic value of PLCE1 in GC was evaluated by the Kaplan-Meier plotter. To explored the potential functions of PLCE1, various bioinformatics analyses were conducted. Furthermore, we also constructed the spatial structure of PLCE1 protein using the homology modeling method to analyze its mutations.ResultsRs3765524 C > T, rs2274223 A > G and rs3781264 T > C in PLCE1 were associated with the increased risk of GC. The overall survival and progression-free survival of patients with high expression of PLCE1 were significantly lower than those with low expression [HR (95% CI) = 1.38 (1.1–1.63), P < 0.01; HR (95% CI) = 1.4 (1.07–1.84), P = 0.01]. Bioinformatic analysis revealed that PLCE1 was associated with protein phosphorylation and played a crucial role in the calcium signal pathway. Two important functional domains, catalytic binding pocket and calcium ion binding pocket, were found by homology modeling of PLCE1 protein; rs3765524 polymorphism could change the efficiency of the former, and rs2274223 polymorphism affected the activity of the latter, which may together play a potentially significant role in the tumorigenesis and prognosis of GC.ConclusionPatients with high expression of PLCE1 had a poor prognosis in GC, and SNPs in PLCE1 were associated with GC risk, which might be related to the changes in spatial structure of the protein, especially the variation of the efficiency of PLCE1 in the calcium signal pathway.

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“…В то же время Z. Xie и соавт. [28] в своем метаанализе, включавшем 43 опубликованных исследо-вания, не обнаружили ассоциации между полиморфизмом гена MBL и РЖ.…”

Section: обзор литературы и клинико-экспериментальное исследование | ...unclassified

“…com / ), что может отражаться на его функциональной активности [7]. Одно из первых исследований уровня экспрессии маннозосвязывающего лектина при РЖ показало зависимость развития заболевания от полиморфизма гена MBL, что, вероятно, сказывается на генетической предрасположенности к этому виду онкологии, хотя это и не подтвердилось по результатам метаанализа [28]. Выраженная экспрессия MR в опухолях желудка являлась фактором неблагоприятного прогноза в китайском исследовании [28].…”

Section: обзор литературы и клинико-экспериментальное исследование | ...unclassified

Mannose antibody levels in gastric cancer patients (literature review and clinical and experimental study)

Nikulin,

Shilova,

Lipatnikov

et al. 2023

Rossijskij bioterapevtičeskij žurnal

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Introduction. Glycans play an important role in the pathogenesis of malignant neoplasms, including stomach cancer. In recent years, the attention of many researchers has been drawn to mannose (Man) – hexose, which is an indispensable component of all N-chains of glycoproteins involved in both normal physiological and pathological processes.Aim. To investigate the role of innate immunity factors and ways to influence them through mannose and mannose-containing glycans in gastric cancer patients. Materials and methods. Data on the role of mannose – one of the key monosaccharides in the formation of glycoprotein N-chains – and its binding receptors (mannose receptor, mannose-binding lectin, antibodies) in gastric cancer since 2006 are presented. Levels of anti-glycan antibodies in blood serum samples of 235 gastric cancer patients and 76 healthy donors were evaluated using a glycochip.Results. It has been shown that the level of IgM-class antibodies to Manβ – the core part of N-glycans – in gastric cancer patients is significantly lower compared to the donor group, regardless of age (p = 0.0001). To assess the effect of age on the levels of antiglycan antibodies, patients were divided into two subgroups – before and after 45 years. In the group under 45 years of age, significant differences in the levels of antiglycan antibodies to Manβ persisted, while significant differences in the levels of antiglycan antibodies to Manβ1-4GlcNAcβ were not observed. when comparing groups of patients and donors older than 45 years, the levels of antibodies to Manβ and Manβ1-4GlcNAcβ were significantly higher only in donors. Conclusion. Deficiency of humoral immunity may be one of the key factors in the initiation and progression of carcinogenesis in humans. In our work, in patients with stomach cancer, we revealed a deficiency of antiglycan antibodies to Manβ and to Manβ1-4GlcNAcβ – core fragments of N-chains of glycoproteins, and the deficiency increased with age. The results of the study are a promising platform for further research aimed not only at studying the role of anti-mannose antibodies, but also at developing approaches to adoptive immunoprophylaxis.

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Estimation of associations between 10 common gene polymorphisms and gastric cancer: evidence from a meta-analysis

Cited by 7 publications

References 30 publications

Innate IgM antibodies to mannose in patients with gastric cancer

Innate IgM antibodies to mannose in patients with gastric cancer

PLCE1 Polymorphisms Are Associated With Gastric Cancer Risk: The Changes in Protein Spatial Structure May Play a Potential Role

Mannose antibody levels in gastric cancer patients (literature review and clinical and experimental study)

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