Estimation of bilirubin using BiliChek™, a transcutaneous bilirubin measurement device: Effects of gestational age and use of phototherapy

Jangaard, Krista; Curtis, Heather; Goldbloom, Richard B.

doi:10.1093/pch/11.2.79

Cited by 40 publications

(33 citation statements)

References 17 publications

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“…In our study, the Pearson's correlation coefficient was significantly lower compared to previous studies [r=0.87 to 0.96] (Bhutani et al, 2000;Engle et al, 2002Engle et al, , 2005Maisels et al, 2004;Slusher et al, 2004;Eggert et al, 2006;Jangaard et al, 2006;Boo and Ishak, 2007;Kolman et al, 2007;Karon et al, 2008;Campbell et al, 2011). Although the 95% CI (-36.213 µmol/l to 61.269 µmol/l) for the TcB method were comparable to previous studies, they are too wide at the specific range of checked bilirubin values.…”

Section: Discussioncontrasting

confidence: 66%

A Comparison between Transcutaneous and Total Serum Bilirubin in Healthy-term Greek Neonates with Clinical Jaundice

et al. 2014

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Abstract:The accuracy of transcutaneous bilirubin meters has been assessed in newborns from various ethnic backgrounds. However, there are limited data on Greek newborns. Our study examined the accuracy of transcutaneous bilirubin measurements in clinically jaundiced healthy-term Greek newborns, using total serum bilirubin as the reference standard, in order to re-evaluate our local guidelines about neonatal jaundice. Clinically jaundiced newborns requiring total serum bilirubin level estimation were recruited prospectively. 368 pairs of total serum bilirubin/transcutaneous bilirubin measurements were taken in 222 newborns, using a direct spectrophotometric device and the BiliCheck device, respectively. The level of agreement between the obtained transcutaneous bilirubin and total serum bilirubin values was assessed. Our data were analysed using the Stata/SE 12.0 (StataCorp LP, USA) statistical programme. The mean (± SD) TSB was 225.4 ± 25.4 µmol/l and the mean (± SD) TcB was 237.9 ± 21.0 µmol/l. The correlation between the values was poor (Pearson's correlation coefficient 0.439; Lin's concordance coefficient 0.377 [95% CI 0.301 to 0.453]; P<0.001).The Bland-Altman analysis demonstrated that transcutaneous bilirubin measurements tended to overestimate the total serum bilirubin value (mean difference 12.5 ± 24.9 µmol/l), with wide 95% limits of agreement (-36.2 µmol/l to 61.3 μmol/l). Transcutaneous bilirubin values did not correlate well with total serum bilirubin values, being often imprecise in predicting the actual total serum bilirubin levels. This permits us to continue estimating total serum bilirubin in clinically jaundiced newborns according to our local guidelines, in order to safely decide the appropriate care plan.© Charles University in Prague -Karolinum Press, 2014Mailing Address: Charalambos Neocleous, MD., PhD., Department of Medical Pediatrics, General Hospital of Drama, Drama, Greece; e-mail: xneoc@yahoo.gr Neocleous Ch.; Adramerina A.; Limnaios S.; Symeonidis S.; Spanou Ch.; Malakozi M.; Mpampalis E.

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Section: Discussioncontrasting

confidence: 66%

A Comparison between Transcutaneous and Total Serum Bilirubin in Healthy-term Greek Neonates with Clinical Jaundice

et al. 2014

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“…Numerous studies have compared the agreement between TcB and TSB [5][6][7][8][9][10][11][12][13][14][15][16]. One review in 2013 summarised the results from 22 studies conducted between 1982 and 2012 ( [5][6][7][8][9][10][11][12][13][14][15][16]), mainly on BiliChek and JM-103 (and its earlier versions) [6].…”

Section: Comparisons With Other Techniquesmentioning

confidence: 99%

“…One review in 2013 summarised the results from 22 studies conducted between 1982 and 2012 ( [5][6][7][8][9][10][11][12][13][14][15][16]), mainly on BiliChek and JM-103 (and its earlier versions) [6]. Two other studies adopted digital photography to predict TSB based on the skin colour in the sternum and forehead [18,31].…”

Section: Comparisons With Other Techniquesmentioning

confidence: 99%

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Screening neonatal jaundice based on the sclera color of the eye using digital photography

Leung

Kapur

Guilliam

et al. 2015

Biomed. Opt. Express

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Abstract:A new screening technique for neonatal jaundice is proposed exploiting the yellow discoloration in the sclera. It involves taking digital photographs of newborn infants' eyes (n = 110) and processing the pixel colour values of the sclera to predict the total serum bilirubin (TSB) levels. This technique has linear and rank correlation coefficients of 0.75 and 0.72 (both p<0.01) with the measured TSB. The mean difference ( ± SD) is 0.00 ± 41.60 µmol/l. The receiver operating characteristic curve shows that this technique can identify subjects with TSB above 205 µmol/l with sensitivity of 1.00 and specificity of 0.50, showing its potential as a screening device.

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“…Thirteen studies 20,21,23,25,26,[32][33][34][35][36][37]39,40 provided results as an analysis of the Bland-Altman difference plots. The studies were published between the years 2003 and 2012, and the majority used either JM-103 (6 studies) or BiliCheck (6 studies) devices except for the study by Karen et al, 26 which used Bilimed.…”

Section: Bland-altman (Tcb -Tsb Differences) Plot Analysismentioning

confidence: 99%

Reliability of Transcutaneous Bilirubin Devices in Preterm Infants: A Systematic Review

Nagar¹,

Vandermeer²,

Campbell

et al. 2013

Pediatrics

108

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BACKGROUND AND OBJECTIVE: Transcutaneous bilirubin (TcB) devices are widely used for the estimation of serum bilirubin levels in term and near-term infants. Our objective was to review the diagnostic accuracy of TcB devices in preterm infants.METHODS: Medline, Embase, Cochrane library, Cumulative Index to Nursing and Allied Health Literature, and Scopus were searched (from database inception date until December 2012). Additional citations were identified by using the bibliographies of selected articles and from conference proceedings. The studies were included if they compared TcB with total serum bilirubin in preterm infants before phototherapy and presented data as correlation coefficients or as BlandAltman difference plots. Data were extracted by 1 reviewer and checked for accuracy by the second reviewer. An assessment tool (quality assessment of diagnostic accuracy studies) was used for risk of bias assessments. RESULTS:Twenty-two studies met the inclusion criteria; 21 studies reported results as correlation coefficients, with pooled estimates of r = 0.83 for each site of measurement. Pooled estimates in infants ,32 weeks' gestation were similar to the overall preterm population (r = 0.89 [95% confidence interval: 0.82-0.93]). For the 2 commonly used TcB devices (ie, JM103 and BiliCheck), the results were comparable at the forehead site, although the JM103 device exhibited better correlation at the sternum. Analysis of the BlandAltman plots (13 studies) revealed negligible bias in measurement at the forehead or sternum site by using either the JM-103 or BiliCheck device; however, the JM-103 device exhibited better precision than the BiliCheck (SD for TcB -total serum bilirubin differences: 24.3 and 31.98 mmol/L, respectively). CONCLUSIONS:The TcB devices reliably estimated bilirubin levels in preterm infants and could be used in clinical practice to reduce blood sampling.

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Estimation of bilirubin using BiliChek™, a transcutaneous bilirubin measurement device: Effects of gestational age and use of phototherapy

Cited by 40 publications

References 17 publications

A Comparison between Transcutaneous and Total Serum Bilirubin in Healthy-term Greek Neonates with Clinical Jaundice

A Comparison between Transcutaneous and Total Serum Bilirubin in Healthy-term Greek Neonates with Clinical Jaundice

Screening neonatal jaundice based on the sclera color of the eye using digital photography

Reliability of Transcutaneous Bilirubin Devices in Preterm Infants: A Systematic Review

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