2022
DOI: 10.1038/s41598-022-13096-2
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Estimation of biological effect of Cu-64 radiopharmaceuticals with Geant4-DNA simulation

Abstract: The aim of this work is to estimate the biological effect of targeted radionuclide therapy using Cu-64, which is a well-known Auger electron emitter. To do so, we evaluate the absorbed dose of emitted particles from Cu-64 using the Geant4-DNA Monte Carlo simulation toolkit. The contribution of beta particles to the absorbed dose is higher than that of Auger electrons. The simulation result agrees with experimental ones evaluated using coumarin-3-carboxylic acid chemical dosimeter. The simulation result is also… Show more

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Cited by 3 publications
(2 citation statements)
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“…Meanwhile, Auger electron emission is the main cause of cytotoxicity of Cu-64, and the important aspect for Auger electrons to be effective is the close proximity to the target [49]. For Cu-64, the Auger electrons have an average energy of 2 keV and an average range of 126 nm with an estimated LET of 7 keV/μm [24,25,59]. The average size of a mammalian cell is approximately 10-100 μum in diameter, and a typical mitochondrion has a diameter of 0.5-1 μm [60,61].…”
Section: Discussionmentioning
confidence: 99%
“…Meanwhile, Auger electron emission is the main cause of cytotoxicity of Cu-64, and the important aspect for Auger electrons to be effective is the close proximity to the target [49]. For Cu-64, the Auger electrons have an average energy of 2 keV and an average range of 126 nm with an estimated LET of 7 keV/μm [24,25,59]. The average size of a mammalian cell is approximately 10-100 μum in diameter, and a typical mitochondrion has a diameter of 0.5-1 μm [60,61].…”
Section: Discussionmentioning
confidence: 99%
“…Commonly used Auger electron emitters include 111 In, 64 Cu, 125 I, and 123 I. , The Auger effect mainly causes DSB when they decay within the mammalian cell nucleus . In addition, Auger electron-emitters generate an assortment of reactive radicals (e.g., OH•, H•, e – aq , etc .…”
Section: Trt Applications For Gbmmentioning
confidence: 99%