Estimation of bone fracture risk using FRAX model in some regions of Russian Federation

Abstract

Keywords: osteoporosis risk factors • 10-year fracture probability • FRAX® • therapeutic intervention threshold • climate and geography effects • basic economic features Purpose: To estimate the absolute risk (AR) of fractures in urban population of some Russian regions using Russia-specific FRAX® model, as well as to evaluate therapeutic intervention threshold (TIT) adopted in Russia.Material and methods: Representative samples of the population from 8 Russian cities included 9143 Russian residents (6324 women and 2819 men) aged 40-69 years (mean age 53.29 ± 0.02 years). AR of fractures was calculated without BMD using the batch processing of data.Results: The average AR of major fractures (MF) was 7.8% (8.9% in women and 5.5% in men, p=0,0001), hip fractures (HF) -0.7% (0.9% in women and 0.4% in men, p=0.0001). In women AR was higher in all age groups across all cities in comparison with that in men both for MF and HF. The proportion of individuals who had a previous fragility fractures was 15.2% and 30.6% from them were determined to be in a highrisk of fractures zone and 69.4% -in the low-risk of fractures zone.Conclusion: The average AR of MF and HF increased with age regardless of participants' gender, and were significantly higher among female population. The majority of the respondents with the previous fragility fractures have been included into the low-risk of fractures zone, which implies the low sensitivity of the TIT currently established for country.

The role and place of the FRAX calculator in initiation osteoporosis treatment: an analysis of the osteoporosis center registry

“…Судя по всему, у них не было других клинических факторов, повышающих вероятность переломов, поскольку, как известно, риск увеличивается параллельно с увеличением числа его факторов [16]. Нельзя не отметить высокую долю лиц с переломами, в том числе множественными, имеющих низкий риск FRAX -67,4%, что может свидетельствовать о низкой чувствительности применяемого в настоящее время в РФ возрастзависимого порога терапевтического вмешательства, что обсуждается и другими исследователями [32,33].…”

The ten-year probability of fractures with the FRAX tool: which threshold for intervention to be used and how?

“…Скрипниковой и соавт. [15], в которое были включены женщины и мужчины в возрасте 40-70 лет из 8 городов Российской Федерации, была показана невысокая прогностическая значимость российской модели FRAX ® . О.А.…”