2013
DOI: 10.1186/1746-6148-9-95
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Estimation of bovine leukemia virus (BLV) proviral load harbored by lymphocyte subpopulations in BLV-infected cattle at the subclinical stage of enzootic bovine leucosis using BLV-CoCoMo-qPCR

Abstract: BackgroundBovine leukemia virus (BLV) is associated with enzootic bovine leukosis (EBL), which is the most common neoplastic disease of cattle. BLV infection may remain clinically silent at the aleukemic (AL) stage, cause persistent lymphocytosis (PL), or, more rarely, B cell lymphoma. BLV has been identified in B cells, CD2+ T cells, CD3+ T cells, CD4+ T cells, CD8+ T cells, γ/δ T cells, monocytes, and granulocytes in infected cattle that do not have tumors, although the most consistently infected cell is the… Show more

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Cited by 65 publications
(52 citation statements)
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“…Although evidence of infection of other peripheral blood cell subpopulations has been reported [76], these results have not been confirmed by others. Soon after infection of a cell, the viral RNA is copied into DNA by the virus-encoded reverse transcriptase.…”
Section: Enzootic Bovine Leukosis and The Bovine Leukemia Viruscontrasting
confidence: 49%
“…Although evidence of infection of other peripheral blood cell subpopulations has been reported [76], these results have not been confirmed by others. Soon after infection of a cell, the viral RNA is copied into DNA by the virus-encoded reverse transcriptase.…”
Section: Enzootic Bovine Leukosis and The Bovine Leukemia Viruscontrasting
confidence: 49%
“…As shown in Figure 1 Panei et al 2013). Among these, the Tax protein of BLV which is a transcriptional activator of viral replication and a key contributor to oncogenic potential, immortalizes some infected cells, probably CD5 + IgM + B cells (Aida et al 1993), and induces polyclonal proliferation.…”
Section: Clinical Stage and Transmissionmentioning
confidence: 99%
“…La transmisión natural del virus se produce principalmente a través de las células infectadas con el provirus integrado (Mammerickx et al, 1987), detectándose altas copias de estos provirus en diferentes subpoblaciones de linfocitos (Panei et al, 2013). Por lo tanto, la sangre es una fuente importante de infección, principalmente en la práctica veterinaria (Hopkins & DiGiacomo 1997;Kohara, 2006;Mammerickx et al, 1987), ya que solo cinco microlitros de sangre periférica inoculados por diferentes vías en forma experimental fueron suficientes para infectar a un bovino (González et al, 2001).…”
Section: Introductionunclassified