Estimation of Cancer Mortality Associated with Repetitive Computed Tomography Scanning

Jong, Pim A. de; Mayo, John R.; Golmohammadi, Kamran; Nakano, Yasutaka; Lequin, Maarten H.; Tiddens, Harm A.W.M.; Aldrich, John E.; Coxson, Harvey O.; Sin, Don D.

doi:10.1164/rccm.200505-810oc

Cited by 146 publications

(87 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Computed tomography (CT) has been used successfully to detail structural changes associated with cystic fibrosis progression, including bronchiectasis and airway wall thickening (9,10). However, the ionizing radiation associated with CT limits its use, particularly for pediatric imaging or multiple imaging sessions to assess treatment efficacy over time (11). Lower dose CT has been developed (12,13), and this reduces the health risks of radiation, but the risks remain significant (14)(15)(16).…”

mentioning

confidence: 99%

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients

Sun

O’Sullivan

Roche

et al. 2011

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To use hyperpolarized (HP) 3 He MR imaging to assess functional lung ventilation in subjects with cystic fibrosis (CF) before and after treatment. Materials and Methods: We performed HP 3He static ventilation MRI scans on three subjects, using a Philips 3.0 Tesla (T) Achieva MRI scanner, before and after 11 days of in-patient treatment with combined intravenous and inhaled therapies for pulmonary exacerbations of CF. We also collected spirometry data. We quantified pulmonary ventilation volume measured with HP 3 He MRI using an advanced semi-automated analysis technique.Results: Following 11 days of treatment with intravenous antibiotics, hypertonic saline, and rhDNase, HP 3 He MR images in one subject displayed a 25% increase in total ventilation volume. Total ventilation volume in the other two subjects slightly decreased. All three subjects showed increases in FEV 1 and FVC following treatment. Conclusion:In all subjects, the HP 3 He MR images provided detailed information on precisely where in the lungs gas was reaching. These data provide additional support for the conclusion that HP noble gas MRI can be a powerful tool for evaluating lung ventilation in patients with cystic fibrosis, but also raise important questions about the correlation between spirometry and HP gas MRI measurements.

show abstract

mentioning

confidence: 99%

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients

Sun

O’Sullivan

Roche

et al. 2011

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Most correctly identified radiography and CT as sources of ionizing radiation. Although children, pregnant women, and women of reproductive age have been identified previously as having an elevated LAR of malignancy due to CT, [21][22][23] one in two respondents were incorrect in quantifying the potential risk of CT to children. These findings are consistent with studies showing poor physician knowledge of LAR due to CT radiation exposure.…”

Section: Discussionmentioning

confidence: 96%

An exploration of Canadian emergency physicians' and residents' knowledge of computed tomography radiation dosing and risk

Barbic

Dankoff

2015

CJEM

View full text Add to dashboard Cite

Objective: The objective of this study was to measure the current knowledge of Canadian emergency physicians and emergency medicine residents regarding computed tomography (CT) radiation dosing and its associated risks. Methods: Three focus groups were conducted as the qualitative element of this study. Cognitive debriefing was carried out to ensure the validity and reliability of the focus group findings and to aid with survey development. A 26-item electronic survey was developed and pilot tested for distribution to the membership of the Canadian Association of Emergency Physicians. Results: Eighteen emergency medicine physicians and three emergency medicine residents participated in the focus groups. Four major themes emerged: 1) physician knowledge of risks associated with CT, 2) risk management strategies, 3) communication, and 4) knowledge translation. The survey response rate was 49.8% (638 of 1,281). The mean respondent age was 40.9 6 9.9 years, and 70.7% were male. Of all respondents, 82.5% were actively practicing attending physicians, 56.4% of all respondents practiced in urban academic emergency departments, and the average time practicing was 10.7 6 9.6 years. Radiography and CT were correctly identified by 92.2% and 95.1% of respondents, respectively, as sources of ionizing radiation, whereas magnetic resonance imaging and ultrasonography were selected by 1.0% and 0.5%, respectively. With respect to the lifetime attributable risk (LAR) of malignancy due to CT, 82.2% of participants correctly identified that abdominal CT increases the risk of cancer by 0.2 to 2%, whereas 51.3% correctly identified that the LAR increases twofold in a 7-year-old boy. When asked to identify populations at risk for potential harm due to ionizing radiation, 92.2% of respondents identified children, 80.3% identified pregnant women, and 71.4% identified women of reproductive age. A minority (37.2%) reported communicating the potential risks of CT to a majority of their patients. Electronic platforms were identified by 74.8% of respondents as their preferred method of knowledge translation on this topic. Conclusions: Canadian emergency medicine physicians and emergency medicine residents demonstrated identifiable gaps in knowledge surrounding CT radiation dose and risk. RÉ SUMÉObjectif: L'é tude visait à mesurer les connaissances actuelles des mé decins d'urgence et des ré sidents en mé decine d'urgence au Canada en ce qui concerne les doses de rayonnement é mis par la tomodensitomé trie (TDM) et les risques associé s. Mé thode: Trois groupes de discussion ont é té formé s à titre d'é lé ment qualitatif de l'é tude. Nous avons procé dé à un bilan cognitif afin de nous assurer de la validité et de la fiabilité des conclusions auxquelles en é taient arrivé s les groupes de discussion, et de faciliter l'é laboration de l'enquê te. Un questionnaire é lectronique en 26 points a é té é laboré , puis soumis à un essai pilote en vue de sa distribution aux membres de l'Association canadienne des mé decins d'urgence. Ré sulta...

show abstract

“…However, many peer reviewed publications make the claim that even a single CT scan can increase cancer risk (33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47). Some articles clearly state that the risk, if any, is low and based on hypothesis driven by theoretical extrapolation of high dose radiation from the atomic bomb to low doses (9,35).…”

Section: Ct Scans Can Cause Cancermentioning

confidence: 99%

Understanding the problem of a parent’s fear of their child getting cancer from CT scan radiation

Cohen

2016

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Estimation of Cancer Mortality Associated with Repetitive Computed Tomography Scanning

Cited by 146 publications

References 32 publications

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients

An exploration of Canadian emergency physicians' and residents' knowledge of computed tomography radiation dosing and risk

Understanding the problem of a parent’s fear of their child getting cancer from CT scan radiation

Contact Info

Product

Resources

About

Estimation of Cancer Mortality Associated with Repetitive Computed Tomography Scanning

Cited by 146 publications

References 32 publications

Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients

Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients

An exploration of Canadian emergency physicians' and residents' knowledge of computed tomography radiation dosing and risk

Understanding the problem of a parent’s fear of their child getting cancer from CT scan radiation

Contact Info

Product

Resources

About

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients

Using hyperpolarized ³He MRI to evaluate treatment efficacy in cystic fibrosis patients