Estimation of Ciprofloxacin Hydrochloride in Bulk and Formulation by Derivative UV-Spectrophotometric Methods

Kharat, Rekha; Jadhav, Santosh; Tamboli, Dilshadbee; Tamboli, Ashpak

doi:10.7439/ijasr.v1i3.1915

Cited by 9 publications

(6 citation statements)

References 19 publications

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“…The linearity of the proposed method is better than spectrophotometric methods and comparable to other fluorimetric methods. The proposed method is less precise and accurate as compared to a reported method [1] which involve the use of CdS QDs but the environment friendly nature of ZnS QDs as compared to CdS QDs outweigh this deficiency.…”

Section: Comparison Of the Proposed Methods With Reported Analytical Methodsmentioning

confidence: 83%

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Mn-DOPPED ZnS QUANTUM DOTS AS SENSITIVE SENSOR FOR DETERMINATION OF CIPROFLOXACIN IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

Jan

Ara

Ali

et al. 2021

J. Chil. Chem. Soc.

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A simple and fast spectrofluorimetric method for determination of ciprofloxacin based on its quenching effect on the fluorescence intensity of colloidal water soluble TGA caped, Mn doped ZnS quantum dots (QDs) has been described. The QDs having characteristic fluorescence spectra with maximum excitation at 315 nm followed by an emission peak at 632 nm were characterized using Energy Dispersive X-Ray and X-ray Diffraction techniques. The effect of various parameters such as concentration of QDs, time, pH, common excipients and metal ions on the quenching phenomenon was investigated. Fluorescence quenching was found to be maximum with 10 µg mL -1 of QDs at pH 8 and fluorescence intensity was observed to be constant upto 45 min. The Stern-Volmer calibration plot of F 0 /F as a function of ciprofloxacin concentration was found to be linear in the range of 0.5-10 µg mL -1 with r² = 0.993. Under optimal experimental conditions, the method was found to be interference free. The percent relative standard deviation of the proposed method, calculated against method blank, was found to be 1.10%. The limit of detection (LOD) and the limit of quantitation (LOQ) for ciprofloxacin (signal to noise ratio 3:1 for LOD and 10:1 for LOQ) were calculated to be 0.15 and 0.50 μg mL -1 respectively. Average percent recoveries (±SD) obtained for spiked commercial formulations; ciprol and ciproquine, and serum and urine samples were found to be in the range of 92.2±1.8% to 99.5±1.5%, 90.5±1.2% to 96.7±1.4% and 94.0±1.2% to 98.5±1.4% respectively. The data evidently proves the potential of the proposed sensor QDs in biological analysis.

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Section: Comparison Of the Proposed Methods With Reported Analytical Methodsmentioning

confidence: 83%

“…Ciprofloxacin (Cf) is a synthetic, broad-spectrum, second-generation fluoroquinolone antibiotic that shows activity against both gram-positive and gram-negative bacteria [1] through inhibition of their DNA gyrase. It is used to treat various bacterial infections, i.e.…”

Section: Introductionmentioning

confidence: 99%

Mn-DOPPED ZnS QUANTUM DOTS AS SENSITIVE SENSOR FOR DETERMINATION OF CIPROFLOXACIN IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

Jan

Ara

Ali

et al. 2021

J. Chil. Chem. Soc.

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“…The correlation coefficient of Langmuir isotherm (R 2 ) was 0.9992 which shows correlation or linear relationship, Thus, it was found that adsorption of CPH correlated well with the Langmuir equation. According to Equation (11), the adsorption constants of Langmuir isotherm model parameters, q max and K L , were obtained as 263.15mg/g and 0.0460L/mg, respectively.…”

Section: Langmuir Isothermmentioning

confidence: 99%

In-Vitro Investigation of CPH Drug-Montmorillonite Clay Interaction

Saeed¹

2021

CTTPR

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The aim of the present work is to explore a naturally occurring clay mineral Montmorillonite (MMT), purified from raw Yemeni bentonite clay, as adsorbent material for ciprofloxacin hydrochloride antibiotic (CPH) in order to investigate the interaction of CPH and MMT. CPH-MMT composites were synthesized and the study design involved the investigation of the effect of three variables, namely; the time, pH and concentration of drug, on the intercalation process. The drug loading and recovery mechanisms were examined and supported by diffusion kinetics laws and adsorption isotherm models. The statistical analysis of the effect of different factors on the adsorption process showed that there was a significant difference in the amount of CPH drug that adsorbed due to variations in these factors. This study showed that the equilibrium time attained after 4 hours and the pH of the drug solution played a crucial role in the intercalation process and the adsorption isotherm was fitted by the Langmuir model with maximum adsorption and followed the pseudo-second-order kinetics. Ciprofloxacin hydrochloride is proved to successfully intercalate into the interlayers of MMT. The intercalation of a drug in MMT follows pseudo-second order kinetics. It is recommended that the overall rate of the adsorption procedure is expected to be controlled by the chemical adsorption process. The adsorption process follows the Langmuir model with a maximum amount of CPH intercalated in MMT being 263.15mg/g. This indicates the homogeneous nature of the MMT surface and the formation of monolayer coverage of CPH on the surface of MMT.

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“…Many analytical methods have been developed to determine CIP residue in various food and environmental samples, such as spectrophotometry [ 5 , 6 , 7 ], capillary electrophoresis [ 8 ], and high-performance liquid chromatography using UV [ 9 ], fluorescence [ 10 , 11 ], diode array [ 12 ], and mass spectrometry [ 13 ]. For the instrumental analysis, sample pre-treatment is essential for the purification and enrichment of trace CIP residue in complex matrices.…”

Section: Introductionmentioning

confidence: 99%

Synergetic Effect of Dual Functional Monomers in Molecularly Imprinted Polymer Preparation for Selective Solid Phase Extraction of Ciprofloxacin

et al. 2021

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Background: Ciprofloxacin (CIP), an important broad-spectrum fluoroquinolone antibiotic, was often used as a template molecule for the preparation of imprinted materials. In this study, methacrylic acid and 2-vinylpyridine were employed for the first time as dual functional monomers for synthesizing ciprofloxacin imprinted polymers. Methods: The chemical and physicochemical properties of synthesized polymers were characterized using Fourier transform-infrared spectroscopy, thermogravimetric analysis-differential scanning calorimetry, scanning electron microscopy, and nitrogen adsorption-desorption isotherm. The adsorption properties of ciprofloxacin onto synthesized polymers were determined by batch experiments. The extraction performances were studied using the solid phase extraction and HPLC-UV method. Results: The molecularly imprinted polymer synthesized with dual functional monomers showed a higher adsorption capacity and selectivity toward the template molecule. The adsorbed amounts of ciprofloxacin onto the imprinted and non-imprinted polymer were 2.40 and 1.45 mg g−1, respectively. Furthermore, the imprinted polymers were employed as a selective adsorbent for the solid phase extraction of ciprofloxacin in aqueous solutions with the recovery of 105% and relative standard deviation of 7.9%. This work provides an alternative approach for designing a new adsorbent with high adsorption capacity and good extraction performance for highly polar template molecules.

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Estimation of Ciprofloxacin Hydrochloride in Bulk and Formulation by Derivative UV-Spectrophotometric Methods

Cited by 9 publications

References 19 publications

Mn-DOPPED ZnS QUANTUM DOTS AS SENSITIVE SENSOR FOR DETERMINATION OF CIPROFLOXACIN IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

Mn-DOPPED ZnS QUANTUM DOTS AS SENSITIVE SENSOR FOR DETERMINATION OF CIPROFLOXACIN IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

In-Vitro Investigation of CPH Drug-Montmorillonite Clay Interaction

Synergetic Effect of Dual Functional Monomers in Molecularly Imprinted Polymer Preparation for Selective Solid Phase Extraction of Ciprofloxacin

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