Estimation of cognitive and affective disorders occurrence in patients with Lyme borreliosis

Oczko-Grzesik, Barbara; L, Kepa; Puszcz-Matlińska, Monika; Pudło, Robert; Żurek, Anna; Badura-Głąbik, Teresa

doi:10.5604/12321966.1229002

Cited by 21 publications

(35 citation statements)

References 17 publications

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“…Causal serotypes of B. burgdorferi sensu lato revealed in the evaluated patients were similar to the results of other Polish studies [65,66,67]. The incidence of hearing loss increases with age and in patients aged 19-44 years it is estimated to be 4.5-5% [68]. The present study demonstrated impairments of the auditory pathway in over one half the patients, especially associated with late LB.…”

Section: Discussionsupporting

confidence: 90%

Estimation of hearing impairment occurrence in patients with Lyme borreliosis – preliminary study

Oczko-Grzesik

Lisowska

Rubicz

et al. 2018

Ann. Acad. Med. Siles.

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Section: Discussionsupporting

confidence: 90%

Estimation of hearing impairment occurrence in patients with Lyme borreliosis – preliminary study

Oczko-Grzesik

Lisowska

Rubicz

et al. 2018

Ann. Acad. Med. Siles.

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“…In the general population, there is a 16.2% lifetime prevalence and a 6.6% prior 12-month prevalence 50. Although depression is not prevalent in the early stages of LAD in patients who are diagnosed and treated early and effectively,51 in the later stages of LAD, the prevalence of depression is significantly higher with findings of 37%,52 37%,53 50%,54 51%,55 64%,56 47% (mood swings),57 and 80% (with intrusive symptoms) 28. Intrusive symptoms can also contribute to causing suicide and violence, and 34% of patients with a history of LAD acquire intrusive symptoms 28.…”

Section: Introductionmentioning

confidence: 96%

Suicide and Lyme and associated diseases

Bransfield¹

2017

NDT

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PurposeThe aim of this paper is to investigate the association between suicide and Lyme and associated diseases (LAD). No journal article has previously performed a comprehensive assessment of this subject.IntroductionMultiple case reports and other references demonstrate a causal association between suicidal risk and LAD. Suicide risk is greater in outdoor workers and veterans, both with greater LAD exposure. Multiple studies demonstrate many infections and the associated proinflammatory cytokines, inflammatory-mediated metabolic changes, and quinolinic acid and glutamate changes alter neural circuits which increase suicidality. A similar pathophysiology occurs in LAD.MethodA retrospective chart review and epidemiological calculations were performed.ResultsLAD contributed to suicidality, and sometimes homicidality, in individuals who were not suicidal before infection. A higher level of risk to self and others is associated with multiple symptoms developing after acquiring LAD, in particular, explosive anger, intrusive images, sudden mood swings, paranoia, dissociative episodes, hallucinations, disinhibition, panic disorder, rapid cycling bipolar, depersonalization, social anxiety disorder, substance abuse, hypervigilance, generalized anxiety disorder, genital–urinary symptoms, chronic pain, anhedonia, depression, low frustration tolerance, and posttraumatic stress disorder. Negative attitudes about LAD from family, friends, doctors, and the health care system may also contribute to suicide risk. By indirect calculations, it is estimated there are possibly over 1,200 LAD suicides in the US per year.ConclusionSuicidality seen in LAD contributes to causing a significant number of previously unexplained suicides and is associated with immune-mediated and metabolic changes resulting in psychiatric and other symptoms which are possibly intensified by negative attitudes about LAD from others. Some LAD suicides are associated with being overwhelmed by multiple debilitating symptoms, and others are impulsive, bizarre, and unpredictable. Greater understanding and a direct method of acquiring LAD suicide statistics is needed. It is suggested that medical examiners, the Centers for Disease Control and Prevention, and other epidemiological organizations proactively evaluate the association between LAD and suicide.

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“…Our results therefore suggest that, possibly except a small sub-population of subjects who are also infected with Toxoplasma, people infected with Borrelia typically express no mental health problems. One large study showed increased seroprevalence of borreliosis in Czech psychiatric patients (33 %) compared to matched healthy control subjects (19 %) (Hajek et al, 2002) and one recent study performed in Poland demonstrated higher incidence of depressive disorders in 75 patients with neuroborreliosis (50.7%) and 46 patients with Lyme arthritis (39.1%) (Oczko-Grzesik et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Toxoplasmosis, but not borreliosis, is associated with psychiatric disorders: A cross-sectional survey on 46 thousand of subjects

Flegr

Horáček²

2017

Preprint

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Infection by the parasite Toxoplasma, which affects about 33% of world population, is associated with increased risk of several mental health disorders, the most strongly with schizophrenia. It is unknown whether toxoplasmosis really plays a substantial role in the etiopathogenesis of these disorders and whether schizophrenia is associated with this infection the most strongly, or whether this association has just been the most intensively studied for historical reasons. We used the data from 3,440 and 7,800 subjects tested for toxoplasmosis and borreliosis, respectively, who took part in an internet survey, for searching in the associations of these infections with 22 mental health disorders and other indices of impaired mental health. The typical symptom associated with toxoplasmosis was anxiety, and the typical toxoplasmosis-associated disorders were autism (OR=4.86), schizophrenia (OR=3.34), attention deficit hyperactivity disorder (OR=3.02), Asperger syndrome (OR=2.49), antisocial personality disorder (OR=1.81), OCD (OR=1.69), and anxiety disorder (OR=1.57). Borreliosis was associated only with symptoms of depression and with major depression (OR=1.65). The negative effects of borreliosis were detectable only in the Toxoplasma-infected subjects. Toxoplasmosis could play a substantial role in the etiopathogenesis of mental health disorders and its association with schizophrenia is the second strongest association, after autism.

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Estimation of cognitive and affective disorders occurrence in patients with Lyme borreliosis

Cited by 21 publications

References 17 publications

Estimation of hearing impairment occurrence in patients with Lyme borreliosis – preliminary study

Estimation of hearing impairment occurrence in patients with Lyme borreliosis – preliminary study

Suicide and Lyme and associated diseases

Toxoplasmosis, but not borreliosis, is associated with psychiatric disorders: A cross-sectional survey on 46 thousand of subjects

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