Estimation of Colchicine in a Poisoned Patient by Using High Performance Liquid Chromatography

Jarvie, D R; Park, Jay J; Stewart, Michael J.

doi:10.3109/15563657909010599

Cited by 49 publications

(20 citation statements)

References 9 publications

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“…Colchiceine can be present in plant extracts besides colchicine, or can appear as a degradation product on storage of 1. [8][9][10][11] Colchiceine can easily form complexes with most of silica based phases, which can be explained by the properties of its ring system especially ring C with a hydroxyl group at C-10 position and neighbouring carbonyl group at carbon atom C-9. It is difficult to detect and separate colchiceine from plant extracts because of its chelating properties.…”

Section: Introductionmentioning

confidence: 99%

Colchiceine Complexes with Lithium, Sodium and Potassium Salts − Spectroscopic Studies

Kurek¹,

Barczyński²

2016

Croat. Chem. Acta

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Colchiceine complexes with Li + , Na + and K + cations have been synthesized and studied by 1 H and 13 C NMR, FT-IR, FAB MS and UV-Vis. It has been shown that colchiceine forms stable complexes especially with lithium cation and the most stable structures of the complexes are those in which the acetamide groups are involved in the coordination process. The structures of the colchiceine complexes with Li + , Na + and K + cations are discussed in details.

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Section: Introductionmentioning

confidence: 99%

Colchiceine Complexes with Lithium, Sodium and Potassium Salts − Spectroscopic Studies

Kurek¹,

Barczyński²

2016

Croat. Chem. Acta

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“…Furthermore, even if taken in very large doses, it may not always be detected in the blood [16,17]. Colchicine also enters enterohepatic circulation before entering the bile and feces.…”

Section: Discussionmentioning

confidence: 99%

The etiology and autopsy findings in Colchicine intoxication-related deaths

İritaş¹,

Dinç²,

Akduman³

et al. 2016

Med-Science

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Colchicine is a drug which has a very narrow therapeutic range. This drug has been commonly used for Familial Mediterranean Fever (FMF), Behçet's disease, gout arthritis and acute pseudo gout attacks. In this study, the investigation reports and autopsy reports written by the Council of Forensic Medicine of Ankara between the years 2010-2014 were retrospectively analyzed to find out presence in the cases related to colchicine. Six cases were identified as colchicine intoxication, while three of them used colchicine for medical purpose. In four cases, colchicine was found to have been used for suicidal purpose. Among these four cases, two used colchicine for treatment. In all of our cases, colchicine was detected in bile specimen. Alveolar pulmonary edema and petechial hemorrhage were observed in the lung in all cases. Colchicine was detected in blood in four of the cases. In two cases, the concentration was found to be in therapeutic ranges (0,012 mg/L and 0,018 mg/L), while the other two, in lethal levels (0.099 mg/L and 0,264 mg/L). The most frequent histopathological finding is alveolar pulmonary edema in colchicine intoxication autopsies. Colchicine is widely used alkaloid drugs with narrow therapeutic ranges. More than 0.8 mg / kg in the acute high dose has usually fatal effects. The deaths resulted from colchicine intoxication are mainly suicide-oriented. Similar to other suicides with medicines, they are common among women. In our cases, colchicine was used for intention of suicide in four incidents (66, 66%).

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“…31 Given the poor safety profile of colchicine, it is of concern that participants did not know the maximum dosage of colchicine, giving rise to risky behaviour and increasing the potential for overdose. [12][13][14] Sharing of medicines was not widespread in this study, but this practice increases the risk of a potential overdose. Colchicine can be fatal in overdose and treatment options for overdose remain limited.…”

Section: Discussionmentioning

confidence: 99%

Patient awareness, knowledge and use of colchicine: an exploratory qualitative study in the Counties Manukau region, Auckland, New Zealand

et al. 2016

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IntroductIon: Treatment of gout, specifically with colchicine, varies globally. Colchicine can be fatal due to its narrow therapeutic index and potential for interactions. In New Zealand, cases of intentional and unintentional colchicine overdose have been documented. AIms:To explore patients' knowledge on the use of gout medicines, and in particular their awareness of the maximum dose of colchicine, the dangers of colchicine overdose, and their opinions on restricting colchicine dispensing. The study also investigates where patients receive gout information.methods: Thirty people with gout presenting to their regular gout clinic in Auckland currently or previously taking colchicine were invited to participate in a 30-min semi-structured interview. Data were analysed using a general inductive thematic approach.FIndIngs: Overall, participants had a lack of knowledge regarding colchicine and used variable doses during an acute gout attack. Participants were unsure of the maximum dose of colchicine and several took more than prescribed. The prophylactic use of colchicine and allopurinol varied from 3 weeks to 15 years. Mixed views were reported on restricting colchicine supply. Most participants received gout information from their general practitioner (GP).conclusIon: Poor understanding of colchicine contributed to inappropriate use and highlights the need for targeted patient education. Considerable inter-patient variability exists in the use of colchicine for acute gout, suggesting the efficacy of low dose regimens be explored. The length of adjunctive colchicine use, as part of a prophylaxis regimen, needs to be regularly reviewed and tailored to each patient. Further research is required on limiting the amount of colchicine dispensed.

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Estimation of Colchicine in a Poisoned Patient by Using High Performance Liquid Chromatography

Abstract: A rapid method was developed for the estimation of colchicine in plasma. The method was used to determine colchicine levels in a fatal case of colchicine self-poisoning.

Cited by 49 publications

References 9 publications

Colchiceine Complexes with Lithium, Sodium and Potassium Salts − Spectroscopic Studies

Colchiceine Complexes with Lithium, Sodium and Potassium Salts − Spectroscopic Studies

The etiology and autopsy findings in Colchicine intoxication-related deaths

Patient awareness, knowledge and use of colchicine: an exploratory qualitative study in the Counties Manukau region, Auckland, New Zealand

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