Estimation of daily intake and risk assessment of organophosphorus pesticides based on biomonitoring data – The internal exposure approach

Katsikantami, Ioanna; Colosio, Claudio; Alegakis, Athanasios; Tzatzarakis, Manolis; Vakonaki, Elena; Rizos, Apostolos K.; Sarigiannis, D; Tsatsakis, Aristidis

doi:10.1016/j.fct.2018.10.047

Cited by 112 publications

(43 citation statements)

References 95 publications

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“…Generally reverse phase-HPLC (RP-HPLC) and ion-pair liquid chromatography (IP-IC) is used for fast identification of food colors in drinks as well as all other foods like candy, sweets, mixtures etc. Specifically, when extensive treatment is not possible, there is a possibility to do selective detection using spectrometry in the visible region [86].…”

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confidence: 99%

A review on analytical methods for the determination of natural colorants (green) in food commodities and beverages

2020

Biointerface Res Appl Chem

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A wide variety of natural colorants are generally used for coloring food stuffs to make them more attractive, informative and reinstate the original color lost during the production process. However, in many countries the usage of natural colorants is limited due to their low stability. Green is one of the most important secondary colors as far as consumer goods are concerned due to looking fresh and natural. Chlorophyll and its metal derivatives like copper or zinc chlorophylls have been used as green colorant in food and pharmaceuticals. The regulatory authorities and food analysts have adopted precise analytical methods in assessing quality and safety of food products. These techniques mainly deal with determination of quality, quantity, colorant stability, safety and utility limits of colorants in food stuffs. These aspects are sensitively regulated by regulatory authorities as well as domestic and food suppliers. In this review, we discuss various extraction methods that are executed for extracting the chlorophyll and metallochlorophyllins from complex food commodities and beverages. In addition, different extraction methods used for food commodities have been presented. Exclusively the present manuscript reviews various analytical techniques used for the analysis of Na-Cu-Chlorophyllin (Na-Cu-Chl) employed in food products as food colorant.

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confidence: 99%

A review on analytical methods for the determination of natural colorants (green) in food commodities and beverages

2020

Biointerface Res Appl Chem

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“…Exposure to these OPPs can take place via various sources, including direct exposure, air, water, and food. Both the acute and the chronic health effects of overexposure to OPPs are well characterized, including neurological, digestive, reproductive, and respiratory disorders . Once these OPPs have entered the human body they undergo several metabolisms, typically in the liver, intestine, and lungs.…”

Section: Introductionmentioning

confidence: 99%

“…Once these OPPs have entered the human body they undergo several metabolisms, typically in the liver, intestine, and lungs. The pervasive utilization of these chemicals and the potentially harmful effects towards human health have raised need among researchers to evaluate human exposure to them . OPPs, particularly dimethoate, oxydemeton‐methyl, pirimiphos‐methyl, parathion, chlorpyrifos, parathion‐methyl, and dichlorvos, are bio‐metabolized into metabolites such as diethyl phosphate (DEP), diethyl thiophosphate (DETP), dimethyl phosphate (DMP), dimethyl thiophosphate (DMTP), and dimethyl dithiophosphate (DMDTP) .…”

Section: Introductionmentioning

confidence: 99%

“…Both the acute and the chronic health effects of overexposure to OPPs are well characterized, including neurological, digestive, reproductive, and respiratory disorders. [5][6][7][8][9][10][11][12] Once these OPPs have entered the human body they undergo several metabolisms, typically in the liver, intestine, and lungs. The pervasive utilization of these chemicals and the potentially harmful effects towards human health have raised need among researchers to evaluate human exposure to them.…”

Section: Introductionmentioning

confidence: 99%

“…The pervasive utilization of these chemicals and the potentially harmful effects towards human health have raised need among researchers to evaluate human exposure to them. [7][8][9] OPPs, particularly dimethoate, oxydemeton-methyl, pirimiphos-methyl, parathion, chlorpyrifos, parathion-methyl, and dichlorvos, are bio-metabolized into metabolites such as diethyl phosphate (DEP), diethyl thiophosphate (DETP), dimethyl phosphate (DMP), dimethyl thiophosphate (DMTP), and dimethyl dithiophosphate (DMDTP). [7][8][9][10][11][12] The chemical structures of the metabolites of OPPs are displayed in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

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Rapid and sensitive analytical procedure for biomonitoring of organophosphate pesticide metabolites in human urine samples using a vortex‐assisted salt‐induced liquid–liquid microextraction technique coupled with ultra‐high‐performance liquid chromatography/tandem mass spectrometry

Pasupuleti

Tsai

Lin

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale Organophosphate pesticides (OPPs) are the most commonly used insecticides around the world in various agricultural and domestic practices, and humans are frequently exposed to these hazardous insecticides that can lead to several chronic health effects. Therefore, a fast and sensitive analytical method is required for biomonitoring the markers of OPPs in humans for exposure estimation. In this study, a fast and sensitive analytical procedure was developed for the determination of the metabolites of OPPs in human urine samples. Methods Metabolites of OPPs were extracted from 2 mL of urine sample using a novel vortex‐assisted salt‐induced liquid–liquid microextraction (VA‐SI‐LLME) technique, and the preconcentrated metabolites were analyzed by ultra‐high‐performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS). Various factors affecting the efficiency of VA‐SI‐LLME were thoroughly investigated. Results The metabolites of OPPs exhibited very good linearity over the concentration range between 0.05 and 50 ng mL−1 with coefficient (r2) values ranging between 0.9986 and 0.9999. The method showed excellent sensitivity with detection limits ranging from 0.01 to 0.03 ng mL−1 and quantification limits from 0.03 to 0.05 ng mL−1. The developed method was applied to the analysis of real samples and the recoveries ranged between 85.0 and 114.1% with related standard deviations <5%. Conclusions The results showed the VA‐SI‐LLME/UHPLC/MS/MS method to be a simple, rapid, sensitive, and selective analytical procedure for the biomonitoring of the metabolites of OPPs in humans. This efficient and cost‐effective analytical method could be a potential alternative method for the biomonitoring of the metabolites of pesticides in humans.

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Enhanced magnetic relaxation switching immunoassay for chlorpyrifos based on tyramine signal amplification

Zhan,

Wu,

Dong

2023

Food Safety and Health

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Chlorpyrifos, an organophosphorus pesticide, is widely used in agriculture to protect crops from insects. However, the presence of its residues in food has caused widespread concern due to the serious risks to human health. Traditional detection methods suffer from limitations, such as low sensitivity, long detection time, and complicated operations. Herein, based on the tyramine signal amplification (TSA) strategy, we developed a sensitive and rapid magnetic relaxation switching (MRS) immunosensor for the detection of chlorpyrifos. Wherein, magnetic Fe3O4 nanoparticles modified with tyramine (MNP150‐tyramine) acted as magnetic probes for magnetic relaxation signal output. In the presence of hydrogen peroxide (H2O2) and horseradish peroxidase (HRP), tyramine can be converted to the highly reactive intermediate that covalently binds with the nearby proteins, such as HRP and antibody, thus assembling MNPs to magnetic clusters and showing changes in transverse relaxation time (T2) signals. Based on the “antibody–antigen” immunoreaction, chlorpyrifos could make a connection of HRP/antibody‐modified MNPs and MNP150‐tyramine with a result of MNPs aggregation and strong T2 signals. In this study, the TSA‐MRS method showed sensitive detection of chlorpyrifos with a limit of detection of 0.54 ng/mL, a 4.5‐fold enhancement in the sensitivity compared with the ELISA method, providing an alternative method for the detection of harmful substances in food samples.

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Estimation of daily intake and risk assessment of organophosphorus pesticides based on biomonitoring data – The internal exposure approach

Cited by 112 publications

References 95 publications

A review on analytical methods for the determination of natural colorants (green) in food commodities and beverages

A review on analytical methods for the determination of natural colorants (green) in food commodities and beverages

Rapid and sensitive analytical procedure for biomonitoring of organophosphate pesticide metabolites in human urine samples using a vortex‐assisted salt‐induced liquid–liquid microextraction technique coupled with ultra‐high‐performance liquid chromatography/tandem mass spectrometry

Enhanced magnetic relaxation switching immunoassay for chlorpyrifos based on tyramine signal amplification

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