Estimation of daily intake of potentially toxic elements from urban street dust and the role of oral bioaccessibility testing

Okorie, Alexander; Entwistle, Jane; Dean, John R.

doi:10.1016/j.chemosphere.2011.09.047

Cited by 115 publications

(30 citation statements)

References 57 publications

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“…Sample collection for further analysis generally arises from the stomach and/or the small intestine phases, where applicable. In contrast, fewer studies have been carried out to simulate exposure to inhalation of such contaminants and in most cases the simulant used is predominantly Gamble's fluid (or variants of), a simulant of lung surfactant fluid with a pH of 7.3 Berlinger et al, 2008;Okorie et al, 2012).…”

Section: International Guidelines Andmentioning

confidence: 99%

Effect of weathering product assemblages on Pb bioaccessibility in mine waste: implications for risk management

Palumbo-Roe

Wragg

Cave

et al. 2013

Environ Sci Pollut Res

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General assessments of orebody types and associated mine wastes with regards to their environmental signature and human health hazards are needed to help managing present and historical mine waste facilities.Bioaccessibility tests and mineralogical analysis were carried out on mine waste from a systematic sampling of mine sites from the Central Wales orefield, UK.The bioaccessible Pb widely ranged from 270 to 20300 mg/kg (mean 7250 mg/kg; median 4890 mg/kg) and the bioaccessible fraction from 4.53 % to >100 % (mean 33.2 %; median 32.2 %), with significant (p=0.001) differences among the mine sites. This implies sensitivity of bioaccessibility to site-specific conditions and suggests caution in the use of models to assess human health impacts generalised on the basis of the mineral deposit type. Mineralogical similarities of the oxidation products of primary galena provided a better control over the observed Pb bioaccessibility range. The higher Pb bioaccessibility (%) was related to samples containing cerussite, irrespective of the presence of other Pb minerals in the mineral assemblage; lower Pb bioaccessibility resulted where anglesite was the main Pb mineral phase and cerussite was absent.

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Section: International Guidelines Andmentioning

confidence: 99%

Effect of weathering product assemblages on Pb bioaccessibility in mine waste: implications for risk management

Palumbo-Roe

Wragg

Cave

et al. 2013

Environ Sci Pollut Res

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“…Exposure from environmental contaminants are normally considered against three exposure pathways, specifically, ingestion, inhalation and dermal contact. The oral (ingestion) pathway, considered the critical exposure route when modelling public open space, residential, and commercial settings (DEFRA, 2014a), has been the focus of much research to assess the human risk assessment from exposure to environmental contaminants predominantly via hand-to-mouth (deliberate) or unintentional ingestion of soils and related materials (Boisa et al, 2013;Cai et al, 2016;Intawongse and Dean, 2006;Li et al, 2014;Lorenzi et al, 2012;Okorie et al, 2012;Oomen et al, 2002;Smith et al, 2011;Wragg et al, 2009;Wragg et al, 2011). However, given the increasing acknowledgement of the association of PM concentrations (the chemical composition, as well as the physical presence) with both short-term and long-term health consequences (Kelly and Fussell, 2015), and the recognition that it is the soluble fraction rather than the total element content that has more direct links to health effects (Adamson et al, 2000;Ghio and Devlin, 2001;Heal et al, 2005), the inhalation exposure pathway was the focus of this current study.…”

Section: Introductionmentioning

confidence: 99%

Use of simulated epithelial lung fluid in assessing the human health risk of Pb in urban street dust

Dean

Elom

Entwistle

2017

Science of The Total Environment

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“….Introduction: The occurrence and distribution of high concentration of PTEs in urban dusts have been widely reported (Okorie et al, 2012;Xinwei et al, 2009;Al-Khashman, 2007). They sources are also well documented (Wei et al, 2010;Manasreh, 2010).…”

Section: Introductionmentioning

confidence: 99%

Oral bioaccessibility of potentially toxic elements (PTEs) in urban dusts of Abakaliki, Ebonyi State, Nigeria

Elom¹,

Entwistle²,

Dean

2014

Journal of Applied Sciences and Environmental Management

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ABSTRACT:A literature survey has shown that no study has investigated the oral bioaccessibility of PTEs in Nigeria dusts. Studies on human health risk of PTEs from urban Nigeria dust have been based only on total elemental concentrations. Whilst this protocol is useful in assessing human health of PTEs, it could lead to an over estimation of the risk considering the elemental sequestration in the dust samples. This study deviated from previous studies by examining the total concentrations as well as the oral bioaccessibility of 8 PTEs in 15 urban dust samples collected from Abakaliki, Ebonyi State, Nigeria. The result showed that high concentrations of Pb (ranging from 236 -1815 mg/kg) were observed in 5 locations. The Unified Bioaccessibility Method (UBM) was used to investigate the oral bioaccessibility of these PTEs in the urban dust samples. The result revealed that all the PTEs were more bioaccessible in the gastric phase that the gastric + intestinal phase. The lead tolerable daily intake (TDI), as well as the bioaccessible TDI, was computed and results compared with a guideline value. © JASEM http://dx.doi.org/10.4314/jasem.v18 i2.13.Introduction: The occurrence and distribution of high concentration of PTEs in urban dusts have been widely reported (Okorie et al., 2012;Xinwei et al., 2009;Al-Khashman, 2007). They sources are also well documented (Wei et al., 2010;Manasreh, 2010). The presence of these PTEs in urban dusts is a potential threat to human health and the ecosystem in general. This is because these elements could enter the human body via the exposure pathways (oral ingestion, inhalation and dermal absorption) (Aelion et al., 2008). In addition, it has been reported that these PTEs have irreversible adverse effects on humans particularly children due to their pica behaviour, physiology, unique exposures and special vulnerabilities (Landrigan et al., 2000). This makes children at a higher risk as their immature organs tend to be more susceptible to PTEs than other contaminants (Egeghy et al., 2011).A literature survey has shown that only a few authors (e.g. Shinggu et al., 2007;Mashi et al., 2005) have investigated the occurrence of PTEs in Nigerian urban dusts, but none for Abakaliki, Ebonyi State. The survey also showed that all the studies determined only the total elemental concentrations. No study has investigated the bioaccessibility of PTEs in Nigerian dust. It is to be noted that in assessing the human health risk of PTEs, it is not the total concentration of PTEs in urban dust that is of greatest concern but the fraction that is released in the human body (bioaccessible fraction) when dust is ingested. Thus, the use of only total elemental concentration in assessing human health risk of PTEs could be seen as an over estimation of the risk associated with oral ingestion of soil based on the principle of PTEs sequestration within various heterogeneous dust samples; a scenario whereby the total elemental content present in the ingested dust is not readily accessible for absorption and trans...

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Estimation of daily intake of potentially toxic elements from urban street dust and the role of oral bioaccessibility testing

Cited by 115 publications

References 57 publications

Effect of weathering product assemblages on Pb bioaccessibility in mine waste: implications for risk management

Effect of weathering product assemblages on Pb bioaccessibility in mine waste: implications for risk management

Use of simulated epithelial lung fluid in assessing the human health risk of Pb in urban street dust

Oral bioaccessibility of potentially toxic elements (PTEs) in urban dusts of Abakaliki, Ebonyi State, Nigeria

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