“…Under the three scenarios, the strategy with optimal control limits the proportion of diabetics with complications to less than 25% and hence reduces the rate of mortality caused by diabetes essentially due to complications (CVDs, kidney failure, amputations, blindness,). Moreover, beyond mortality, the reduction of complications reduces the socio-economic burden of diabetes, including direct and indirect costs as well as intangible and not quantifiable costs such as inconvenience, anxiety, pain and more generally lower quality of life [13]. In the real world, achievement of optimal control can be obtained by acting on behavioral factors like healthy diet, physical activity, smoking and alcohol reduction; and metabolic risks like overweight/obesity and hypertension.…”