Estimation of dose to gonads from gamma emitters present in the body

Snyder, W.S.; Ford, Michael T.; Warner, G.G.

doi:10.1051/radiopro/19700504271

Cited by 2 publications

(7 citation statements)

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“…Other point kernels generated by the EGS4 Monte-Carlo code have recently been proposed by Furhang et al [119] for 14 radionuclides in an aqueous medium ( 123 I, 124 I, 125 I, 131 I, 111 In, 64 Cu, 67 Cu, 67 Ga, 68 Ga, 186 Re, 188 Re, 153 Sm, 117m Sn, and 99m Tc). The results are expressed by providing for each radionuclide the coefficients of a series of polynomials and exponentials approximating the calculated values.…”

Section: Dose Point Kernels For Photonsmentioning

confidence: 98%

“…The first describes the biological effects of 125 I [186]. The second [187] describes the emission spectra of the principal Auger-emitters found in the literature ( 55 Fe, 67 Ga, 99m Tc, 111 In, 113m In, 115m In, 123 I, 125 I, 193m Pt, 195m Pt, 201 Tl, 203 Pb), as calculated by Monte-Carlo simulation. The use of these spectra is recommended (with respect to the conventional tables [97]) when dosimetry is performed for targets less than 1 µm in diameter.…”

Section: Therapeutic Alpha-emittersmentioning

confidence: 99%

“…The EGS4 Monte-Carlo code has also been used to generate point kernels for monoenergetic electrons (50 keV to 3 MeV) and for eight radionuclides ( 32 P, 67 Cu, 90 Y, 105 Rh, 131 I, 153 Sm, 186 Re, and 188 Re) [117].…”

Section: Dose Point Kernel Approachesmentioning

confidence: 99%

“…The integration of monoenergetic point kernels into beta emission spectra was achieved by Prestwich et al [15] for six radionuclides potentially usable in radioimmunotherapy ( 32 P, 67 Cu, 90 Y, 131 I, 186 Re and 188 Re) in order to provide radionuclide point kernels. It is noteworthy that this approach does not take the possible electron emissions of the radionuclides into account.…”

Section: Dose Point Kernels For Electronsmentioning

confidence: 99%

“…5 Estimates of absorbed fractions for monoenergetic photon sources uniformly distributed in various organs of a heterogeneous phantom [67,68] No. 7 Distribution of absorbed dose around point sources of electrons and beta particles in water and other media [69] The point of departure for MIRD formalism is the adoption of the absorbed fraction concept introduced by Ellet et al [59,60].…”

Section: No 4/6mentioning

confidence: 99%

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Dosimetry and Microdosimetry of Targeted Radiotherapy

Bardiès

Pihet²

2000

CPD

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Dosimetry in targeted radiotherapy (TR) uses different calculation methods, whose degree of refinement is closely conditioned by the particular objective sought. It is more generally performed to establish a correlation between the quantity of radiation delivered to a target and the biological damage observed or that can be reliably predicted. It can thus be used to optimise treatments and allow comparison of different therapeutic approaches, as well as to study the basic methods of irradiation of biological matter. Two broad types of investigations can be found in the literature: microdosimetric ones (stochastic approaches used to study energy deposits) and macrodosimetric ones (non-stochastic or deterministic approaches). The mathematical formalism is consistent between these two types, and the calculation methods currently used are often similar. This review presents different approaches to the dosimetry of radionuclides used in TR. The introduction defines the general problem, the role of dosimetry in TR and the specific problems raised by targeting (non-uniformity of source distributions). The first part considers the types of calculation methods found in TR in relation to the basic quantities used to represent stochastic energy deposit on a cellular scale. In particular, it compares the formalism and the methods used in microdosimetric or conventional macrodosimetric approches. Although microdosimetry, or even track structure calculations, can provide the basic elements for modelling the absorbed dose process, a simplified dosimetric approach may be adequate to describe the phenomena observed. The scheme proposed by the MIRD committee relates to such an approach and is presented together with other methods allowing the calculation of the mean dose delivered (analytic methods, dose point kernels, Monte-Carlo, etc.). The second part shows the application range for the various methods, providing selected examples of dosimetric approaches in TR on different scales, from the organ (or tissues) to the cell or even DNA, and a brief presentation of bone marrow dosimetry.

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Section: Dose Point Kernels For Photonsmentioning

confidence: 98%

Section: Therapeutic Alpha-emittersmentioning

confidence: 99%

Section: Dose Point Kernel Approachesmentioning

confidence: 99%

Section: Dose Point Kernels For Electronsmentioning

confidence: 99%

Section: No 4/6mentioning

confidence: 99%

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Dosimetry and Microdosimetry of Targeted Radiotherapy

Bardiès

Pihet²

2000

CPD

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Estimation of age-dependent internal dose from radiopharmaceuticals

Henrichs¹,

Kaul²,

Roedler³

1982

pmb

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The age-dependence of the radiation dose absorbed in a target organ or the total body is determined by the mass, size, shape and separation of the organs as well as by the metabolic behaviour of the radionuclide compound. Using values of the specific absorbed dose for adults, the age-dependent effective dose equivalents for 28 radiopharmaceuticals (62 radionuclides) were calculated by modifying the above mentioned values, considering radiation type, organ mass and source-target separation. From the results, the currently used mathematical models for the modification of values of specific absorbed doses in the adult prove to be of sufficient accuracy. In comparison with the few available values calculated by Monte Carlo-techniques, our method overestimates the specific absorbed fractions by a factor of four in the least favourable case. For practical radionuclide dose estimates, these deviations are of minor importance as long as the availability of reliable information on the metabolic behaviour of radionuclide compounds and radiopharmaceuticals as a function of age is extremely limited. Considering, however, both the parenteral administration and the short half-life of radionuclides used in paediatric nuclear medicine, this uncertainty in regard to the gastrointestinal absorption and the biological half-lives is of little consequence for the results of absorbed dose calculations.

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Estimation of dose to gonads from gamma emitters present in the body

Cited by 2 publications

References 0 publications

Dosimetry and Microdosimetry of Targeted Radiotherapy

Dosimetry and Microdosimetry of Targeted Radiotherapy

Estimation of age-dependent internal dose from radiopharmaceuticals

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