Estimation of efficiency of empirical antibiotic therapy of catheter-associated infection in a urological hospital

Abstract

An analysis of case histories of 119 patients who underwent treatment in the urology department of the Voronezh City Clinical Emergency Hospital No. 10 was performed. All patients were drained with a urethral catheter, a bacteriological examination of the urine was performed, and empirical antibiotic therapy was prescribed. Microflora growth was detected in the urine of 30 (25.2%) patients, most often revealed Klebsiella spp. and Enterococcus faecalis. A high frequency of resistance of uropathogens to antibacterial drugs prescribed as empirical therapy was noted. 66% were resistant to ceftriaxone, and 70% of the isolated microorganism strains to ciprofloxacin. Significantly lower resistance was noted for amikacin and doxycycline. To increase the effectiveness of empirical antibiotic therapy in patients with catheter-associated urinary tract infections, it is necessary to select antibacterial drugs based on the results of monitoring the sensitivity of hospital strains, followed by treatment correction in accordance with the results of urine bacteriological studies.

Microbiological monitoring of causative agents of nosocomial infection in the urological clinic

“…Кузьменко и соавт. [23], которые при бактериологическом исследовании 119 образцов мочи из уретрального катетера выявили рост микрофлоры в диагностически значимом титре у 30 (25,2 %) пациентов, находившихся на лечении в урологическом стационаре. При этом среди выделенных штаммов грамотрицательных микроорганизмов первой по частоте была Klebsiella spp.…”

“…Кузьменко и соавт. [23] оценивали также антибиотикорезистентность выделенных микроорганизмов. Отмечена высокая частота резистентности уропатогенов к цефтриаксону (66 %) и ципрофлоксацину (70 %), которые использовали в качестве препаратов для эмпирической антибиотикотерапии у пациентов с уретральным катетером.…”