Estimation of Fat‐free Mass at Discharge in Preterm Infants Fed With Optimized Feeding Regimen

Larcade, Julie; Pradat, Pierre; Buffin, Rachel; Leick-Courtois, Charline; Jourdes, Emilie; Picaud, Jean‐Charles

doi:10.1097/mpg.0000000000001261

Cited by 10 publications

(9 citation statements)

References 15 publications

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“…Along with higher protein intake, the data of pilot post-hoc analysis showed that infants who received at least 30 days of targeted fortified milk exhibited higher fat-free mass than those in the standard fortification group. Previous trials that examined body composition parameters among the targeted preterm infants that were fed have provided mixed results [14,21,30]. McLeod et al [14] fortified HM using a multi-component human milk fortifier, a protein powder and an energy supplement.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies, however, have shown that infants supplemented with protein alone had better weight gain and positive nitrogen balance [18][19][20]. In addition, the influence of human milk on fat-free mass accretion in preterm infants has recently been investigated [21]. Yet, few researchers have investigated the influence of targeted fortification on body composition outcomes, which have emerged as a necessary measure of nutrition adequacy [10,14].…”

Section: Introductionmentioning

confidence: 99%

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Targeted Breast Milk Fortification for Very Low Birth Weight (VLBW) Infants: Nutritional Intake, Growth Outcome and Body Composition

et al. 2020

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Despite improvements in nutritional management, preterm infants continue to face high rates of postnatal growth restriction. Because variability in breast milk composition may result in protein and energy deficits, targeted fortification has been advocated. We conducted an interventional study to compare body composition and growth outcomes of very low birth weight infants fed targeted protein-fortified human milk (HM) with those fed standard fortified HM. If mother’s own milk was not available, donor milk was used. Weekly analysis of HM with mid-infrared spectroscopy was conducted and additional protein was added to the fortified HM to ensure a protein intake of 4 g/kg/day. Weekly anthropometric measurements were done. Prior to discharge or at 37 weeks, corrected age skinfold thickness (SFT) measurements as well as body composition measurement using air displacement plethysmography were done. Among 36 preterm infants enrolled, those in the targeted group (n = 17) received more protein and had a larger flank SFT at study end than those in the standard group (n = 19). A pilot post-hoc analysis of subjects having at least 30 intervention days showed a 3% higher fat-free mass in the targeted group. Use of a targeted fortification strategy resulted in a higher protein intake and fat-free mass among those receiving longer intervention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Targeted Breast Milk Fortification for Very Low Birth Weight (VLBW) Infants: Nutritional Intake, Growth Outcome and Body Composition

et al. 2020

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“…Larcade et al [11] reported that the number of days very preterm infants were fed human milk during their hospital stay positively correlated with fat-free mass content at discharge. Accordingly, Huang et al [8] conducted a meta-analysis investigating the effect of breastfeeding and formula feeding on the body composition of 642 preterm infants (<37 weeks of gestational age).…”

Section: Discussionmentioning

confidence: 99%

“…While some authors have investigated the determinants of body composition, including human milk feeding, in very preterm infants at the time of hospital discharge [10,11], there is a paucity of data on early determinants of body composition in late preterm infants who are recognized to be undergoing a critical period of development [12]. Huang et al [8] have conducted a systematic review and meta-analysis, including infants born before completion of the 37th week of gestational age, to investigate whether body composition at term-corrected age differs between breastfed and formula-fed infants.…”

Section: Introductionmentioning

confidence: 99%

Does Human Milk Modulate Body Composition in Late Preterm Infants at Term-Corrected Age?

et al. 2016

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(1) Background: Late preterm infants account for the majority of preterm births and are at risk of altered body composition. Because body composition modulates later health outcomes and human milk is recommended as the normal method for infant feeding, we sought to investigate whether human milk feeding in early life can modulate body composition development in late preterm infants; (2) Methods: Neonatal, anthropometric and feeding data of 284 late preterm infants were collected. Body composition was evaluated at term-corrected age by air displacement plethysmography. The effect of human milk feeding on fat-free mass and fat mass content was evaluated using multiple linear regression analysis; (3) Results: Human milk was fed to 68% of the infants. According to multiple regression analysis, being fed any human milk at discharge and at term-corrected and being fed exclusively human milk at term-corrected age were positively associated with fat-free mass content(β = −47.9, 95% confidence interval (CI) = −95.7; −0.18; p = 0.049; β = −89.6, 95% CI = −131.5; −47.7; p < 0.0001; β = −104.1, 95% CI = −151.4; −56.7, p < 0.0001); (4) Conclusion: Human milk feeding appears to be associated with fat-free mass deposition in late preterm infants. Healthcare professionals should direct efforts toward promoting and supporting breastfeeding in these vulnerable infants.

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“…52,53 Recent research has also indicated a potential cumulative effect of human milk feeding on promotion of fat free mass deposition, which, in turns, appears to promote cognitive outcome. [54][55][56] …”

Section: Health Outcomes In Preterm Infantsmentioning

confidence: 99%

Human milk: composition and health benefits

2017

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Breastfeeding is widely acknowledged as the normal and unequalled method for feeding infants due to its associated health benefits, both for the infant and the mother. The World Health Organization recommends that infants are exclusively breastfed up to the completion of six months of age, with breastfeeding continuing to be an important part of the diet until the infant is at least two years old. The several health benefits associated with breastfeeding are driven by the combined action of the nutritional and bioactive components in human milk and the magnitude of the majority of the ascertained biological effects is directly dependent on breastfeeding duration. This review briefly summarizes the current knowledge on the composition of human milk and provides an overview on its functional effects on health outcomes, focusing on the latest research results.

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Estimation of Fat‐free Mass at Discharge in Preterm Infants Fed With Optimized Feeding Regimen

Abstract: Although previous estimation methods were useful for estimating FFM at discharge, an equation adapted to present populations of preterm infants with "modern" neonatal care and nutritional practices is required for accuracy.

Cited by 10 publications

References 15 publications

Targeted Breast Milk Fortification for Very Low Birth Weight (VLBW) Infants: Nutritional Intake, Growth Outcome and Body Composition

Targeted Breast Milk Fortification for Very Low Birth Weight (VLBW) Infants: Nutritional Intake, Growth Outcome and Body Composition

Does Human Milk Modulate Body Composition in Late Preterm Infants at Term-Corrected Age?

Human milk: composition and health benefits

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