Innovation policies are currently one of the main axes for improving the efficiency of national economies in developed and developing countries. The innovation policy includes a comprehensive system of activities. In Russia, increasing the specific weight of commercial entities engaged in innovative activities is among the most important objectives for the short term. The aim of our study was to evaluate the use of innovation based on taking into account the specific weight of organizations that perform innovations in the total number of organizations operating in the regions of Russia. Our study was based on official statistical information on the 82 regions of Russia for 2017-2019. Economic-mathematical models have been developed that describe the specific weight of the organizations that implement innovation. There are no significant changes in the indicators for the years indicated. It has been shown that, to date, almost one in five organizations in the Russian Federation has used innovation in their activities. In addition, they have identified the regions with maximum and minimum values of the specific weightings of innovative organizations for 2019.