Estimation of gastric cancer burden attributable toHelicobacter pyloriinfection in Asia

Abstract

Background Helicobacter pylori causes large burden of gastric cancer (GC) in Asia. We aimed to comprehensively quantify the burden of GC attributable to H. pylori infection in Asia. Methods We searched related articles from January 1998 to December 2020 to obtain the prevalence and relative risks (or odds ratio) of GC associated with H. pylori in Asia. The burden of GC attributable to H. pylori infection was quantified by Population Attributable Fraction (PAF) and Disability-adjusted life-years (DALYs). Results We quantified the burden of GC attributable to H. pylori infection with 415.6 thousand DALYs and 38.03% PAF through the five included Asian countries in 2019. The study found that the burden had obvious regional differences. The DALYs ranged from 298.9 thousand in China to 1.9 thousand in Malaysia, and the PAFs were between 58.00% in Japan and 30.89% in China. The average prevalence of H. pylori in the included general population was estimated to be 56.29%. Conclusions Helicobacter pylori poses a huge disease burden of GC to the population, and its eradication should receive attention, especially in the countries with high incidence of and mortality due to GC.

How readable and quality are online patient education materials about Helicobacter pylori?: Assessment of the readability, quality and reliability

“…H pylori eradication is important, especially in countries with a high incidence of gastric cancer and associated mortality. [3] In a comprehensive study, the cohort data of 4982 individuals enrolled in the DAIKO study between 2008 and 2010 were examined. The study emphasized that in a birth-year-matched cohort (n = 3.376), the incidence of all cancers was significantly higher in H pylori antibody-positive individuals than in H pylori antibody-negative individuals (P = .00328).…”

“…H pylori eradication is important, especially in countries with a high incidence of gastric cancer and associated mortality. [ 3 ]…”

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“…The average prevalence of H. pylori in the studied Asian populations (China, Iran, Japan, Korea and Malaysia) was estimated to be 56.3%. 39 …”

Prevention of malignant digestive system tumors should focus on the control of chronic inflammation

“…Moreover, less than 5% of infected hosts will develop cancer, likely due to differences in bacterial genetics, host genetics, age of infection acquisition, and environmental factors[ 117 ]. Based on world population data, the attributable fraction of noncardiac GC attributable to H. pylori infection is 89%[ 12 , 118 ], and the burden varies widely among regions[ 119 ].…”