Estimation of Genetic Parameters for Milk Production Traits in Holstein Dairy Cattle

Cho, Chungil; Cho, Kwang-Hyun; Choy, Yun Ho; Choi, J. G.; Choi, Tae-Jeong; Park, Byoungho; Lee, Seungsu

doi:10.5187/jast.2013.55.1.7

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…In gEBV estimation, we assumed that heritability of the three milk traits (milk production, milk fat, and milk proteins) were 0.23, 0.20, and 0.19, respectively. These heritabilities were reported in a previous study using Korean Holstein population [ 12 ].…”

Section: Discussionsupporting

confidence: 81%

Genome-association analysis of Korean Holstein milk traits using genomic estimated breeding value

Shin

Lee

Park

et al. 2015

Asian-Australas J Anim Sci

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ObjectiveHolsteins are known as the world’s highest-milk producing dairy cattle. The purpose of this study was to identify genetic regions strongly associated with milk traits (milk production, fat, and protein) using Korean Holstein data.MethodsThis study was performed using single nucleotide polymorphism (SNP) chip data (Illumina BovineSNP50 Beadchip) of 911 Korean Holstein individuals. We inferred each genomic estimated breeding values based on best linear unbiased prediction (BLUP) and ridge regression using BLUPF90 and R. We then performed a genome-wide association study and identified genetic regions related to milk traits.ResultsWe identified 9, 6, and 17 significant genetic regions related to milk production, fat and protein, respectively. These genes are newly reported in the genetic association with milk traits of Holstein.ConclusionThis study complements a recent Holstein genome-wide association studies that identified other SNPs and genes as the most significant variants. These results will help to expand the knowledge of the polygenic nature of milk production in Holsteins.

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Section: Discussionsupporting

confidence: 81%

Genome-association analysis of Korean Holstein milk traits using genomic estimated breeding value

Shin

Lee

Park

et al. 2015

Asian-Australas J Anim Sci

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“…Previous studies have obtained similar heritability estimates for MY305, FY305, and PY305 of 0.30, 0.28, and 0.25 [19] and 0.23, 0.19, and 0.19 [20], respectively.…”

Section: Resultsmentioning

confidence: 59%

Comparison of genome-wide association and genomic prediction methods for milk production traits in Korean Holstein cattle

Lee

Dang

Choy

et al. 2019

Asian-Australas J Anim Sci

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Objective The objectives of this study were to compare identified informative regions through two genome-wide association study (GWAS) approaches and determine the accuracy and bias of the direct genomic value (DGV) for milk production traits in Korean Holstein cattle, using two genomic prediction approaches: single-step genomic best linear unbiased prediction (ss-GBLUP) and Bayesian Bayes-B. Methods Records on production traits such as adjusted 305-day milk (MY305), fat (FY305), and protein (PY305) yields were collected from 265,271 first parity cows. After quality control, 50,765 single-nucleotide polymorphic genotypes were available for analysis. In GWAS for ss-GBLUP (ssGWAS) and Bayes-B (BayesGWAS), the proportion of genetic variance for each 1-Mb genomic window was calculated and used to identify informative genomic regions. Accuracy of the DGV was estimated by a five-fold cross-validation with random clustering. As a measure of accuracy for DGV, we also assessed the correlation between DGV and deregressed-estimated breeding value (DEBV). The bias of DGV for each method was obtained by determining regression coefficients. Results A total of nine and five significant windows (1 Mb) were identified for MY305 using ssGWAS and BayesGWAS, respectively. Using ssGWAS and BayesGWAS, we also detected multiple significant regions for FY305 (12 and 7) and PY305 (14 and 2), respectively. Both single-step DGV and Bayes DGV also showed somewhat moderate accuracy ranges for MY305 (0.32 to 0.34), FY305 (0.37 to 0.39), and PY305 (0.35 to 0.36) traits, respectively. The mean biases of DGVs determined using the single-step and Bayesian methods were 1.50±0.21 and 1.18±0.26 for MY305, 1.75±0.33 and 1.14±0.20 for FY305, and 1.59±0.20 and 1.14±0.15 for PY305, respectively. Conclusion From the bias perspective, we believe that genomic selection based on the application of Bayesian approaches would be more suitable than application of ss-GBLUP in Korean Holstein populations.

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Genomic Prediction and Genome‐Wide Association Studies for Productivity, Conformation and Heat Tolerance Traits in Tropical Smallholder Dairy Cows

Bang,

Hayes,

Lyons

et al. 2024

J Animal Breeding Genetics

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Genomic selection (GS) and genome‐wide association studies (GWAS) have not been investigated in Vietnamese dairy cattle, even for basic milk production traits, largely due to the scarcity of individual phenotype recording in smallholder dairy farms (SDFs). This study aimed to estimate heritability (h2) and test the applicability of GS and GWAS for milk production, body conformation and novel heat tolerance traits using single test day phenotypic data. Thirty‐two SDFs located in either the north (a lowland vs. a highland) or the south (a lowland vs. a highland) of Vietnam were each visited for an afternoon and the next morning to collect phenotype data of all lactating cows (n = 345). Tail hair from each cow was sampled for subsequent genotyping with a 50K SNP chip at that same visit. Milk production traits (single‐test day) were milk yield (MILK, kg/cow/day), energy corrected milk yield adjusted for body weight (ECMbw, kg/100 kg BW/day), fat (mFA, %), protein (mPR, %) and dry matter (mDM, %). Conformation traits were body weight (BW, kg) and body condition score (BCS, 1 = thin to 5 = obese). Heat tolerance traits were panting score (PS, 0 = normal to 4.5 = extremely heat‐stressed) and infrared temperatures (IRTs, °C) at 11 areas on the external body surface of the cow (inner vulval lip, outer vulval surface, inner tail base surface, ocular area, muzzle, armpit area, paralumbar fossa area, fore udder, rear udder, forehoof and hind hoof), assessed by an Infrared Camera. Univariate linear mixed models and a 10‐fold cross‐validation approach were applied for GS. Univariate single SNP mixed linear models were applied for the GWAS. Estimated h2 (using the genotype information to build relationships among animals) were moderate (0.20–0.37) for ECMbw, mFA, mPR, mRE, BW, BCS and IRT at rear udder; low (0.08–0.19) for PS and other IRTs; and very low (≤ 0.07) for MILK, ECM and mDM. Accuracy of genomic estimated breeding values (GEBVs) was low (≤ 0.12) for MILK, ECM, mDM and IRT at hind hoof; and moderate to high (0.32–0.46) for all other traits. The most significant regions on chromosomes (BTA) associated with milk production traits were 0.47–1.18 Mb on BTA14. Moderate to high h2 and moderate accuracies of GEBVs for mFA, mPR, ECMbw, BCS, BW, PS and IRTs at rear udder and outer vulval surface suggested that GS using single test day phenotypic data could be applied for these traits. However, a greater sample size is required to decrease the bias of GEBVs by GS and increase the power of detecting significant quantitative trait loci (QTLs) by GWAS.

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Estimation of Genetic Parameters for Milk Production Traits in Holstein Dairy Cattle

Cited by 3 publications

References 3 publications

Genome-association analysis of Korean Holstein milk traits using genomic estimated breeding value

Genome-association analysis of Korean Holstein milk traits using genomic estimated breeding value

Comparison of genome-wide association and genomic prediction methods for milk production traits in Korean Holstein cattle

Genomic Prediction and Genome‐Wide Association Studies for Productivity, Conformation and Heat Tolerance Traits in Tropical Smallholder Dairy Cows

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