2013
DOI: 10.1186/1471-2369-14-265
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Estimation of glomerular filtration rate from serum creatinine and cystatin C in octogenarians and nonagenarians

Abstract: BackgroundEquations to estimate GFR have not been well validated in the elderly and may misclassify persons with chronic kidney disease (CKD). We measured GFR and compared the performance of the Modification of Diet in Renal Disease (MDRD), the Chronic Kidney Disease-Epidemiology Collaboration (CKD-Epi) and the Berlin Initiative Study (BIS) equations based on creatinine and/or cystatin C in octogenarians and nonagenarians.MethodsUsing cross-sectional analysis we assessed 95 very elderly persons (mean 85 years)… Show more

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Cited by 77 publications
(93 citation statements)
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“…17 Using these equations in children, young adults, the elderly, and people with cirrhosis and HIV also confirmed the high diagnostic performance. [18][19][20][21] With our results, we can probably conclude that the CKD-EPI-creatinine-cystatin C can be used reliably in CGN patients.…”
Section: Discussionmentioning
confidence: 78%
“…17 Using these equations in children, young adults, the elderly, and people with cirrhosis and HIV also confirmed the high diagnostic performance. [18][19][20][21] With our results, we can probably conclude that the CKD-EPI-creatinine-cystatin C can be used reliably in CGN patients.…”
Section: Discussionmentioning
confidence: 78%
“…Other studies that have compared the CKD-EPI and BIS equations using standardized serum creatinine and cystatin C assays report that they show generally similar performance to each other across the range of metrics, although there is some variation among studies. [9][10][11][12] The CAPA equation was developed in northern European adults and children and Japanese adults. A previous report has demonstrated similar performance of the CAPA and CKD-EPI cystatin C equations in the CKD-EPI external validation data set.…”
Section: Discussionmentioning
confidence: 99%
“…Several reports have demonstrated that eGFR based on the combination of both standardized serum creatinine and cystatin C is more accurate than eGFR based on either marker alone, [6][7][8] but there are few studies using standardized serum creatinine and cystatin C to evaluate these equations in elderly individuals. [9][10][11][12][13] Current guidelines recommend using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations for GFR estimation in clinical practice or other equations using standardized creatinine and cystatin C if they are more accurate than the CKD-EPI equations. 14 Among other equations, only the Japanese equations, 15,16 the Berlin Initiative Study (BIS) equations, 17 and the Caucasian and Asian pediatric and adult subjects (CAPA) equation 18 are based on standardized creatinine and standardized cystatin C assays.…”
mentioning
confidence: 99%
“…Previous studies have shown that the BIS1, LMr, and FAS formulas yield better results in terms of accuracy, precision, and bias in elderly populations when compared to the MDRD, the Cockcroft-Gault, and also the CKD-EPI equation [10,11,13,15] . Therefore, we view the FAS equation-based prevalence of 25.4% as the most valid estimation of CKD prevalence for our cohort.…”
Section: Discussionmentioning
confidence: 99%