Estimation of Heavy Metals in Different Brands of Amlodipine Besylate Tablet Dosage Forms by Inductively Coupled Plasma-Mass Spectrometry (Icp-Ms)

Abstract

The aim of this study is to estimate heavy metals in different brands of amlodipine besylate tablet dosage forms by inductively coupled plasma-mass spectrometry (ICP-MS). In many laboratories around the world as the instrument of choice for performing trace metal analysis is ICP-MS. ICP-MS using Kinetic Energy Discrimination (KED) mode was used. Samples are assimilated using multi-wave sample digestion system. Each element standards of conc. 1000 mg/l was prepared and followed by serial dilution with 2% nitric acid. The validation was performed as per USP232 standards for the different brands of commercially available samples. Parameters such as linearity, accuracy, precision, Limit of detection (LOD), Limit of Quantification (LOQ) were evaluated. Calibration curves were linear and co-relation co-efficient (r 2 ) was 0.995 for all elements. LOD is divided into two components, method detection limit (MDL) and instrumental detection limit (IDL). The MDL limits (in ppb) of 75

The quality of medicines for the prevention and management of hypertensive disorders of pregnancy: A systematic review

“…(five studies) (see Table 4) [30][31][32][33][34], and antihypertensive medicines-amlodipine (seven studies), nifedipine (two studies), methyldopa (three studies), enalapril (three studies) and hydralazine (one study) (see Table 5) [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. No study assessing quality of labetalol was identified.…”

“…We found 15 studies on the quality of antihypertensives (Table 5) [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. Seven studies evaluated the quality of amlodipine-two studies from India and Nepal found no evidence of poorquality amlodipine [36,38].…”

“…We found 15 studies on the quality of antihypertensives (Table 5) [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. Seven studies evaluated the quality of amlodipine-two studies from India and Nepal found no evidence of poorquality amlodipine [36,38]. In contrast, a Nigerian study reported three of ten (30.0%) amlodipine samples were counterfeit as they were unregistered within regulatory bodies, and their API content did not comply with British Pharmacopoeia standard.…”