The groundwater contained in the alterites is one of the main sources of water supply for many households in the city of Yaounde and its surroundings. Information from the field and laboratory studies was compiled and analyzed in order to understand the hydrogeological context of this superficial aquifer. Preliminary results show a staged morphology of the alteration mantle (regolith) of Yaounde migmatitic representative of the polyphase character of alteration processes observed in all granito-gneissic formations of the world. This mantle has a multilayer system whose soil sets could have a different hydrodynamic functioning. The values of the hydraulic conductivity have a normal distribution and vary over four orders of magnitude, attesting the variability of the hydraulic conductivity of the soft materials. The hydrometric and piezometric characteristics indicate that the aquifer has highly heterogeneous zones that would be related to the morphostructural character of the region. The δ 18 O mean values of the rain (−2.47‰) and shallow groundwater (−2.57‰) are not significantly different. They indicate that the recharge of the shallow aquifer of Yaounde Precambrian basement is recent and is done directly by infiltration of precipitation without any notable change due to evaporation. These programs relate to (a) "physical, hydrodynamic, and bacteriological characterizations of groundwater resources in the sedimentary and basement areas of Cameroon" and (b) "the impact of climate change and human activities on the water resources of Cameroon. " The activities carried out within the framework of these programs are more implemented in the alterites of the geological formations of the South Cameroon Plateau specifically those of the region of Yaounde and its surroundings [7][8][9][10][11][12]. In fact, because of the deficit service of the water distribution network, the groundwater of shallow unconfined aquifer constitutes, for many households in this region, one of the main sources of water supply.This chapter is a review of the main results obtained during the research carried out in the aquifers of the Pan-African basement of the Yaounde series in Central Africa. It is a synthesis of the results of the Theses [4,[13][14][15][16][17], DEA, DESS, and Master [11, 18, 19] studies focusing on the hydrogeological context of the upper part of the weathered and cracked basement of the Mfoundi watershed, which includes 11 sub-basins, Anga'a and Mingosso in Mefou (Figure 1). This compilation makes it possible to fill the gaps and/or to improve the knowledge of the aquifers of the weathered mantle in humid tropical zone, particularly in this part of South Cameroon facing the problems of drinking water supply.Groundwater Hydrology 12