Estimation of IL-6, INFγ, and Lipid Profile in Suicidal and Nonsuicidal Adults with Major Depressive Disorder

Eidan, Ali J.; AL-Harmoosh, Raad A.; Al-Amarei, Hassam M.

doi:10.1089/jir.2018.0134

Cited by 33 publications

(19 citation statements)

References 66 publications

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“…Then, a further 90 articles were excluded, due to their lack of the required exposure or outcome, being duplicates, or comprising bipolar subjects. Finally, 32 studies [3,7,9,10,13,15,[17][18][19][20][21][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44], comprising a total of 7,068 participants, met the eligibility criteria and were included in our meta-analysis for assessing the associations between serum lipid concentrations and attempted suicide in MDD patients (Fig 1). A summary of the characteristics of the eligible studies is presented in Table 1.…”

Section: Search Resultsmentioning

confidence: 99%

“…A majority of studies have suggested that lower serum cholesterol concentrations may be associated with suicide attempt in MDD patients [3, 10, 31, 33-36, 38-44, 46, 48-52]. Seven other studies [17,18,31,39,42,46,48] have found that suicide attempters with MDD had significantly lower LDL-C concentrations than non-attempters with MDD. A recent meta-analysis [16] consistently found an inverse association between lipid concentrations and suicidality.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, studies that have comprehensively pooled evidence on the association between serum lipid concentrations and attempted suicide only in MDD patients remained sparse. In addition, although there is growing evidence from epidemiological studies of such an association [17][18][19][20][21][22], this has yet to be clarified and validated.…”

Section: Introductionmentioning

confidence: 99%

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Association between serum lipid concentrations and attempted suicide in patients with major depressive disorder: A meta-analysis

Zhang

Sun

et al. 2020

PLoS ONE

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Background There is growing evidence that serum lipid concentrations may be associated with attempted suicide in patients with major depressive disorder (MDD), but these findings remain controversial. Thus, we performed a comprehensive meta-analysis to quantitatively assess the associations between serum lipid concentrations and attempted suicide in MDD patients. Materials and methods Electronic databases (PubMed, Embase, the Cochrane Library and the China National Knowledge Library) were searched for relevant literature up to 10 February 2020. We used a random-effects model based on heterogeneity amongst studies and generated pooled standardised mean differences (SMDs). Results Thirty-two studies comprising 7,068 subjects met the inclusion criteria. A pooled analysis showed that compared with non-attempters, MDD patients who had attempted suicide had significantly lower serum concentrations of total cholesterol (TC) (SMD: -0.63, 95% CI: -0.83 to -0.44) and low-density lipoprotein cholesterol (LDL-C) (SMD: -0.69, 95% CI: -1.04 to -0.34), but the serum concentrations of high-density lipoprotein cholesterol (HDL-C) (SMD: -0.12, 95% CI: -0.33 to 0.10) and triglycerides (TGs) (SMD: 0.00, 95% CI: -0.20 to 0.20) were not significantly different between the two groups. Subgroup and meta-regression analysis indicated that heterogeneity with respect to TC concentrations may be due to different ages (p = 0.041) and sample sizes (p = 0.016) of studies, and that heterogeneity with respect to HDL-C concentrations may be partly due to different settings of studies (p = 0.017). Conclusions This meta-analysis demonstrated that lower concentrations of TC and LDL-C, but not of HDL-C and TGs, were associated with attempted suicide in MDD patients. This indicates that TC and LDL-C may be useful as biological markers for predicting whether MDD patients may attempt to commit suicide.

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Section: Search Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between serum lipid concentrations and attempted suicide in patients with major depressive disorder: A meta-analysis

Zhang

Sun

et al. 2020

PLoS ONE

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“…Of those, another 5 were removed for reasons shown in ESF Table 5 and, therefore, the meta-analysis was performed on 51 studies. [8][9][10][11][12][13][14][15]17,18,[38][39][40][41][42][43]45,47, and the systematic review on an additional 5 studies. [91][92][93][94][95] Overall, the meta-analysis reports data from 29 from mixed psychiatric disorders, and the others from schizophrenia, adjustment disorders, or other psychiatric disorders not including mood disorders.…”

Section: Search Resultsmentioning

confidence: 99%

“…5 There is robust evidence that major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia are accompanied by activation of the immune-inflammatory response system (IRS) and activation of the compensatory immune-regulatory reflex system (CIRS), which downregulates an overzealous IRS. 6,7 IRS biomarkers include interleukin (IL)-1β 8,9 , IL-6 8,10 , IL-8 11 ; interferon gamma (IFN-γ) 12,13 ; tumor necrosis factor alpha (TNF-α) 9,10 ; neutrophil-tolymphocyte ratio (NLR) 14 ; chemokines 15 ; etc. ), and CIRS biomarkers, e.g.…”

Section: Introductionmentioning

confidence: 99%

Increased neurotoxicity due to activated immune-inflammatory and nitro-oxidative stress pathways in patients with suicide attempts: a systematic review and meta-analysis

Vasupanrajit

Jirakarn

Tunvirachaisakul

et al. 2021

Preprint

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Background: Suicide attempts (SA) frequently occur in patients with mood disorders and schizophrenia, which are both accompanied by activated immune-inflammatory and nitro-oxidative (IO&NS) pathways. Methods: We searched PubMed, Google Scholar, and Web of Science, for articles published from inception until February 1, 2021. We included studies that compared blood biomarkers in psychiatric patients with (SA+) and without SA (SA-) and heathy controls and we combined different IO&NS biomarkers into immune, inflammatory, and neurotoxic profiles and used meta-analysis (random-effect model with restricted maximum-likelihood) to delineate effect sizes with 95% confidence interval (CI). Findings: Our search included 51 studies comprising 4.945 SA+ patients and 24.148 controls. We stratified the control group into healthy controls and SA- patients. SA+ patients showed significantly (p<0.001) increased immune activation (SMD: 1.044; CI: 0.599-1.489), inflammation (SMD: 1.109; CI: 0.505, 1.714), neurotoxicity (SMD: 0.879; CI: 0.465, 1.293), and lowered neuroprotection (SMD: 0.648; CI: 0.354, 0.941) as compared with healthy controls. When compared with SA- patients, those with SA+ showed significant (p<0.001) immune activation (SMD: 0.290; CI: 0.183, 0.397), inflammation (SMD: 0.311; CI: 0.191, 0.432), and neurotoxicity (SMD: 0.315; CI: 0.198, 0.432), and lowered neuroprotection (SMD: 0.341; CI: 0.167, 0.515). Patients with current, but not lifetime, SA showed significant (p<0.001) levels of inflammation and neurotoxicity as compared with controls. Conclusions: Patients with immune activation are at a higher risk of SA which may be explained by increased neurotoxicity due to inflammation and nitro-oxidative stress. This meta-analysis discovered new biomarkers of SA and therapeutic targets to treat individuals with SA.

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Lipids and Suicide Risk

Sublette

2020

Current Topics in Behavioral Neurosciences

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Estimation of IL-6, INFγ, and Lipid Profile in Suicidal and Nonsuicidal Adults with Major Depressive Disorder

Cited by 33 publications

References 66 publications

Association between serum lipid concentrations and attempted suicide in patients with major depressive disorder: A meta-analysis

Association between serum lipid concentrations and attempted suicide in patients with major depressive disorder: A meta-analysis

Increased neurotoxicity due to activated immune-inflammatory and nitro-oxidative stress pathways in patients with suicide attempts: a systematic review and meta-analysis

Lipids and Suicide Risk

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