Estimation of intracranial pressure by ultrasound of the optic nerve sheath in an animal model of intracranial hypertension

Jeng, Brasil Chian Ping; Andrade, Almir Ferreira de; Brasil, Sérgio; Bor‐Seng‐Shu, Edson; Belon, Alessandro Rodrigo; Robertis, Maira; Oliveira, Marcelo de Lima; Rubiano, Andrés M.; Godoy, Daniel Agustín; Teixeira, Manoel Jacobsen; Paiva, Wellingson Silva

doi:10.1016/j.jocn.2021.01.021

Cited by 11 publications

(7 citation statements)

References 52 publications

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“…In a swine model with intracranial balloons, excellent correlations between ONSD and balloon volume, as well as invasively measured ICP, were found [ 221 ].…”

Section: Approaches Of Non-invasive Measurementsmentioning

confidence: 99%

Non-Invasive Intracranial Pressure Monitoring

Müller

Henkes

Gounis³

et al. 2023

JCM

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(1) Background: Intracranial pressure (ICP) monitoring plays a key role in the treatment of patients in intensive care units, as well as during long-term surgeries and interventions. The gold standard is invasive measurement and monitoring via ventricular drainage or a parenchymal probe. In recent decades, numerous methods for non-invasive measurement have been evaluated but none have become established in routine clinical practice. The aim of this study was to reflect on the current state of research and shed light on relevant techniques for future clinical application. (2) Methods: We performed a PubMed search for “non-invasive AND ICP AND (measurement OR monitoring)” and identified 306 results. On the basis of these search results, we conducted an in-depth source analysis to identify additional methods. Studies were analyzed for design, patient type (e.g., infants, adults, and shunt patients), statistical evaluation (correlation, accuracy, and reliability), number of included measurements, and statistical assessment of accuracy and reliability. (3) Results: MRI-ICP and two-depth Doppler showed the most potential (and were the most complex methods). Tympanic membrane temperature, diffuse correlation spectroscopy, natural resonance frequency, and retinal vein approaches were also promising. (4) Conclusions: To date, no convincing evidence supports the use of a particular method for non-invasive intracranial pressure measurement. However, many new approaches are under development.

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“…In a swine model with intracranial balloons, excellent correlations between ONSD and balloon volume, as well as invasively measured ICP, were found [ 221 ].…”

Section: Approaches Of Non-invasive Measurementsmentioning

confidence: 99%

Non-Invasive Intracranial Pressure Monitoring

Müller

Henkes

Gounis³

et al. 2023

JCM

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“…Regarding the animals used for modeling ICH, the following different species were used: Mice or rats ( 14-33 ), pigs ( 34-40 ), dogs ( 41-43 ), monkeys ( 44 ), sheep ( 45 ), cats ( 46 ) and rabbits ( 47 , 48 ). The majority of studies (63%) utilized rats, whereas the model most used is autologous blood intracranial injection (51%).…”

Section: Modelsmentioning

confidence: 99%

“…Studies for ultrasound assessment of the optic nerve sheath diameter ( 34 , 94 ) and transcranial Doppler pulsatility index ( 35 ) have taken advantage of this method because of sudden IHT development. Thus, the balloon model appears to be sufficient for generating oscillations in intracranial pressure measurements as well as for causing an impact on cerebral hemodynamic conditions and valuable for studying the effects of mechanical damage to the brain tissue ( 43 ).…”

Section: Modelsmentioning

confidence: 99%

Animal models for the study of intracranial hematomas (Review)

et al. 2022

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Intracranial hematomas (ICH) are a frequent condition in neurosurgical and neurological practices, with several mechanisms of primary and secondary injury. Experimental research has been fundamental for the understanding of the pathophysiology implicated with ICH and the development of therapeutic interventions. To date, a variety of different animal approaches have been described that consider, for example, the ICH evolutive phase, molecular implications and hemodynamic changes. Therefore, choosing a test protocol should consider the scope of each particular study. The present review summarized investigational protocols in experimental research on the subject of ICH. With this subject, injection of autologous blood or bacterial collagenase, inflation of intracranial balloon and avulsion of cerebral vessels were the models identified. Rodents (mice) and swine were the most frequent species used. These different models allowed improvements on the understanding of intracranial hypertension establishment, neuroinflammation, immunology, brain hemodynamics and served to the development of therapeutic strategies.

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“…The optical nerve is part of the central nervous system and is surrounded by a sheath containing cerebrospinal fluid derived from the subarachnoid space. Because the subarachnoid space is contiguous with the encephalon, changes in the ICP can affect the optical nerve sheath (ONS) and cause variations in its diameter 5 . Optical nerve sheath diameter ultrasonography (ONSUS) is a reliable method for the noninvasive estimation of ICP because it is highly sensitive to variations in sheath diameter 6 .…”

Section: Introductionmentioning

confidence: 99%

Assessing ultrasonographic optic nerve sheath diameter in animal model with anesthesia regimens

et al. 2022

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To determine the normal optical nerve sheath (ONS) diameter ultrasonography (ONSUS) and evaluate the possible effects of drugs on ONS diameter during anesthetic induction in healthy pigs. Methods: Healthy piglets were divided into three groups: a control group, that received xylazine and ketamine (X/K); other that received xylazine, ketamine and propofol (X/K/P); and a third group that received xylazine, ketamine, and thiopental (X/K/T). The sheath diameter was assessed by ultrasonography calculating the average of three measurements of each eye from the left and right sides. Results: 118 animals were anesthetized (49 X/K 33 X/K/P and 39 X/K/T). Mean ONS sizes on both sides in each group were 0.394 ± 0.048 (X/K), 0.407 ± 0.029 (X/K/P) and 0.378 ± 0.042 cm (X/K/T) (medians of 0.400, 0.405 and 0.389, respectively). The ONS diameter varied from 0.287-0.512 cm (mean of 0.302 ± 0.039 cm). For group X/K, the mean diameter was 0.394 ± 0.048 cm. Significant differences in ONS sizes between the groups P and T (X/K/P > X/K/T, p = 0.003) were found. No statistically significant differences were detected when other groups were compared (X/K = X/K/P, p = 0.302; X/K = X/K/T, p = 0.294). Conclusion: Sedation with thiopental lead to significative ONS diameter reduction in comparison with propofol. ONSUS may be useful to evaluate responses to thiopental administration.

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Estimation of intracranial pressure by ultrasound of the optic nerve sheath in an animal model of intracranial hypertension

Cited by 11 publications

References 52 publications

Non-Invasive Intracranial Pressure Monitoring

Non-Invasive Intracranial Pressure Monitoring

Animal models for the study of intracranial hematomas (Review)

Assessing ultrasonographic optic nerve sheath diameter in animal model with anesthesia regimens

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