Estimation of major immunoglobulin profile in oral submucous fibrosis by radial immunodiffusion

Gupta, Dheeraj; Gupta, Mithilesh Kumar; Oswal, Rajesh H.

doi:10.1016/s0300-9785(85)80060-0

Cited by 20 publications

(16 citation statements)

References 8 publications

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“…Raised serum IgG levels have been reported by Gupta et al, Caniff et al, and Shah et al (5,24). The role of active immune phenomenon in OSMF is supported by accelerated body defence and the polyclonal nature of the disease, incidence of autoantibodies and involvement of the DR Locus, altered antigen leading to defective lymphocyte function and hyperactivity of B cells leading to hyperglobulinaemia (5,(24)(25)(26).…”

Section: Discussionmentioning

confidence: 97%

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Correlation of salivary and serum IgG, IgA levels with total protein in oral submucous fibrosis

2011

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Section: Discussionmentioning

confidence: 97%

“…Though it is difficult to explain the reason for differences in IgA in various studies, results do implicate hyperglobulinaemia, imbalance in immunoregulation and alteration in local tissue architecture (5,19,20,24,25,27).…”

Section: Discussionmentioning

confidence: 99%

Correlation of salivary and serum IgG, IgA levels with total protein in oral submucous fibrosis

2011

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“…At least 20 different zinc-containing proteins have been identified, which include anhydrase, alcohol dehyrogenase, leukocyte elastase and insulin [16]. There are conflicting reports in the literature on the decreased levels of serum zinc [8] and on the increased to the normal levels of zinc [17] in cancer patients.…”

Section: Referencesmentioning

confidence: 99%

Estimation of the Serum and the Salivary Trace Elements in OSMF Patients

Kode

Karjodkar²

2013

JCDR

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Objectives: Gutkha packets contain trace elements like copper, zinc, iron and magnesium. This study compared the levels of the trace elements in patients with gutkha eating habits with or without oral submucous fibrosis and in healthy patients.Study Design: A total of 75 patients were included in this study and they were divided into three groups; the individuals with a history of gutkha intake with OSMF, the individuals with a his tory of gutkha intake without OSMF and apparently healthy individuals without OSMF and without any habits.Blood and saliva was collected and they were subjected for analysis by using atomic absorption spectrometry and a differ ential pulse anodic stripping voltmeter. Results:The results were tabulated and they were subjected to a statistical analysis. Conclusion:There was a significant difference in the serum Mg and Fe levels between the patients with habits and the normal healthy individuals. A significant difference was observed in the serum zinc levels in the patients with habits with and without OSMF. Altered serum trace element levels are documented in malignant cases and they are considered to be good biomarkers for malignancies. The serum copper and Zn levels and the Cu/ Zn ratio in OSMF patients can be considered as the markers which show a susceptibility towards cancer.

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“…The immunological ground is one of the priority mechanisms in the multicausal pathogenesis of oral lichen planus in which immunoglobulins [4,5] and autoantibodies [6][7][8][9] play the key roles. Literature reports related to this issue differ.…”

Section: Introductionmentioning

confidence: 99%

“…Literature reports related to this issue differ. Some studies have presented increased [4,5,8,10, 11], reduced [11,12] or even normal [13][14][15] immunoglobulin fractions in patients with oral lichen planus.…”

Section: Introductionmentioning

confidence: 99%

Role of Humoral Mechanisms in Etiology of Lichen Planus

Поповска¹,

Mitik²,

Grchevska³

et al. 2014

Prilozi

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Aim: To examine the role of IgA, CIC and component C3 as indicators of humoral immune response in the etiopathogenesis of oral erosive lichen planus (OELP). Material and method:The study comprised 19 patients with OELP whose samples of blood, saliva and tissue were obtained after carefully taken medical history and clinical examination. Samples of oral mucosa were taken from the site of lesion, i.e. exclusively from buccal mucosa (1 cm in width and length), and from the deep epithelium as well as a segment from the lamina propria. Determination of immunoglobulins in serum and saliva, and determination of component C3, was done using the micro-elisa technique by Rook&Cameron, Engvall and Ulman. Determination of CIC in serum and mixed saliva was done with the PEG (polyethylene glycol) method. Determination of immunoglobulin A and component C3 in biopsy material was done with direct immunofluorescence. Results: Levels of immunoglobulin A in serum in OELP during exacerbation were decreased (1.04 ± 0.49 gr/l) and during remission increased (5.92 ± 0.62) in comparison with the control group (p < 0.001). Levels of CIC during exacerbation and remission were increased (p < 0.001), and component C3 levels were increased in both examined phases in the examined group compared with the control group (p < 0.05). Deposits of IgA were registered in one (5.88%) patient with OELP and component C3 was registered in 3 (17.64%) patients. Conclusion: Changes in IgA values, as well as CIC and component C3, may correlate with changes in oral mucosa emphasizing the role of humoral immune response in the pathogenesis of oral lichen planus.

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Estimation of major immunoglobulin profile in oral submucous fibrosis by radial immunodiffusion

Cited by 20 publications

References 8 publications

Correlation of salivary and serum IgG, IgA levels with total protein in oral submucous fibrosis

Correlation of salivary and serum IgG, IgA levels with total protein in oral submucous fibrosis

Estimation of the Serum and the Salivary Trace Elements in OSMF Patients

Role of Humoral Mechanisms in Etiology of Lichen Planus

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