Estimation of mechanical stiffness by finite element analysis of ultrasound computed tomography (UCT-FEA); a comparison with X-ray µCT based FEA in cancellous bone replica models

Althomali, Marwan A.M.; Wille, Marie‐Luise; Shortell, Matthew P.; Langton, Christian

doi:10.1016/j.apacoust.2017.12.002

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Because of the bioengineering aspects involved in designing and executing these tests, it can be overwhelming to decide on relevant mechanical tests needed for proof-of-concept evaluation. Herein, we provide a brief overview of the common tests that are essential to answer basic questions related to fracture strength, durability, and applicability; comprehensive test methods have been reviewed elsewhere [ 69 , 70 , 71 , 72 , 73 , 74 ]. Successful execution of these tests provides insights into whether revisions are needed for the current innovation or if the device is technically fit to advance into the next step, for instance, evaluation in animal models.…”

Section: Mechanical Characterization Of Bone/bone Implant Devicesmentioning

confidence: 99%

Percutaneous-Reinforced Osteoplasty: A Review of Emerging Treatment Strategies for Bone Interventions

Koirala

Joshi

Duffy

et al. 2022

JCM

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Percutaneous-reinforced osteoplasty is currently being investigated as a possible therapeutic procedure for fracture stabilization in high-risk patients, primarily in patients with bone metastases or osteoporosis. For these patients, a percutaneous approach, if structurally sound, can provide a viable method for treating bone fractures without the physiologic stress of anesthesia and open surgery. However, the low strength of fixation is a common limitation that requires further refinement in scaffold design and selection of materials, and may potentially benefit from tissue-engineering-based regenerative approaches. Scaffolds that have tissue regenerative properties and low inflammatory response promote rapid healing at the fracture site and are ideal for percutaneous applications. On the other hand, preclinical mechanical tests of fracture-repaired specimens provide key information on restoration strength and long-term stability and enable further design optimization. This review presents an overview of percutaneous-reinforced osteoplasty, emerging treatment strategies for bone repair, and basic concepts of in vitro mechanical characterization.

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Section: Mechanical Characterization Of Bone/bone Implant Devicesmentioning

confidence: 99%

Percutaneous-Reinforced Osteoplasty: A Review of Emerging Treatment Strategies for Bone Interventions

Koirala

Joshi

Duffy

et al. 2022

JCM

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“…Finite element analysis (FEA) based on high-resolution 3D image data is also effective for estimating mechanical properties on bone specimens [80,84]. (Although μCT is the most common imaging modality to provide input data for FEA, ultrasound tomography has also been shown to be effective for estimating stiffness in cancellous bone replica models [85]. )…”

Section: E Attenuation Vs Mechanical Propertiesmentioning

confidence: 99%

Mechanisms of Interaction of Ultrasound With Cancellous Bone: A Review

Wear

2020

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Ultrasound is now a clinically-accepted modality in the management of osteoporosis. The most common commercial clinical devices assess fracture risk from measurements of attenuation and sound speed in cancellous bone. This review discusses fundamental mechanisms underlying the interaction between ultrasound and cancellous bone. Because of its two-phase structure (mineralized trabecular network embedded in soft tissue-marrow), its anisotropy, and its inhomogeneity, cancellous bone is more difficult to characterize than most soft tissues. Experimental data for the dependences of attenuation, sound speed, dispersion, and scattering on ultrasound frequency, bone mineral density, composition, microstructure, and mechanical properties are presented. The relative roles of absorption, scattering, and phase cancellation in determining attenuation measurements in vitro and in vivo are delineated. Common speed of sound metrics, which entail measurements of transit times of pulse leading edges (to avoid multipath interference), are greatly influenced by attenuation, dispersion, and system properties including center frequency and bandwidth. However, a theoretical model has been shown to be effective for correction for these confounding factors in vitro and in vivo. Theoretical and phantom models are presented to elucidate why cancellous bone exhibits negative dispersion, unlike soft tissue, which exhibits positive dispersion. Signal processing methods are presented for separating "fast" and "slow" waves (predicted by poro-elasticity theory and supported in cancellous bone) even when the two waves overlap in time and frequency domains. Models to explain dependences of scattering on frequency and mean trabecular thickness are presented and compared with measurements. Anisotropy, the effect of the fluid filler medium (marrow in vivo or water in vitro), phantoms, computational modeling of ultrasound propagation, acoustic microscopy, and nonlinear properties in cancellous bone are also discussed.

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“…Dual-energy X-ray absorptiometry (DXA) and the quantitative computed tomography (QCT) are the major methods to diagnose the bone quality and fracture [14]- [19]. Currently, DXA is considered a clinical gold standard for estimating mineral content in skeleton tissue and fracture risk [20].…”

Section: Introductionmentioning

confidence: 99%

Effect of Spectral Estimation on Ultrasonic Backscatter Parameters in Measurements of Cancellous Bones

Liu

et al. 2019

IEEE Access

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Estimation of mechanical stiffness by finite element analysis of ultrasound computed tomography (UCT-FEA); a comparison with X-ray µCT based FEA in cancellous bone replica models

Cited by 6 publications

References 31 publications

Percutaneous-Reinforced Osteoplasty: A Review of Emerging Treatment Strategies for Bone Interventions

Percutaneous-Reinforced Osteoplasty: A Review of Emerging Treatment Strategies for Bone Interventions

Mechanisms of Interaction of Ultrasound With Cancellous Bone: A Review

Effect of Spectral Estimation on Ultrasonic Backscatter Parameters in Measurements of Cancellous Bones

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