2016
DOI: 10.1039/c5ay02901e
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Estimation of methylglyoxal in cow milk – an accurate electrochemical response time based approach

Abstract: An electrochemical biosensor based on a glyoxalase 1 modified platinum electrode with a ceria nano-interface was developed and shown to be a promising tool for the analysis of methylglyoxal in cow milk.

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Cited by 13 publications
(3 citation statements)
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“…Furthermore, Ramachandra Bhat and coworkers reported an electrochemical enzymatic sensor based on CeO 2 (as nano-interface), GSH (as a cofactor), and glyoxalase1 (GLO 1) (as an enzyme), for the sensitive determination of MG in Cow Milk (LOD: 2.14 nM; linear range: 5-50 µM) [89]. The proposed detection mechanism is as follows: 1) the GSH is oxidized to GSSG according to a reversible process involving the exchange of two electrons and two protons; 2) after adding MG to the solution, the oxidized glutathione (GSSG) reacted with MG to form hemithioacetal (HTA).…”
Section: Methylglyoxalmentioning
confidence: 99%
“…Furthermore, Ramachandra Bhat and coworkers reported an electrochemical enzymatic sensor based on CeO 2 (as nano-interface), GSH (as a cofactor), and glyoxalase1 (GLO 1) (as an enzyme), for the sensitive determination of MG in Cow Milk (LOD: 2.14 nM; linear range: 5-50 µM) [89]. The proposed detection mechanism is as follows: 1) the GSH is oxidized to GSSG according to a reversible process involving the exchange of two electrons and two protons; 2) after adding MG to the solution, the oxidized glutathione (GSSG) reacted with MG to form hemithioacetal (HTA).…”
Section: Methylglyoxalmentioning
confidence: 99%
“…However, specificity and precision were less in these types of electrochemical biosensors. Whereas, in the case of enzyme-based electrochemical biosensors [13,[16][17][18][19][20][21], high specificity, accuracy and rapidness can be achieved. They were used extensively to detect biological molecules and toxins in clinical diagnosis, food products and in the environment.…”
Section: Introductionmentioning
confidence: 99%
“…They were used extensively to detect biological molecules and toxins in clinical diagnosis, food products and in the environment. A similar system was developed using the ionic conductor cerium oxide (CeO 2 ) [21] which has higher sensitivity but lack the capability to overcome potential interferents and respond rapidly. Thus, in this work, a specific and accurate method for the measurement of MG was considered using glyoxalase 1 (GLO 1) based electrochemical biosensor.…”
Section: Introductionmentioning
confidence: 99%