Estimation of population-based utility weights for gastric cancer-related health states

Abstract

BackgroundThis study aimed to generate utility weights of gastric cancer-related health states from the perspective of the Korean general population.MethodsThe Korean adults (age ≥19 years) included in the study were sampled using multistage quota sampling methods stratified by sex, age, and education level. Nine scenarios for hypothetical gastric cancer-related health states were developed and reviewed. After consenting to participate, the subjects were surveyed by trained interviewers using a computer-assisted personal interview method. Participants were asked to perform standard gamble tasks to measure the utility weights of 5 randomly assigned health states (from among nine scenarios). The mean utility weight was calculated for each health state.ResultsThree hundred twenty-six of the 407 adults who completed this study were included in the analysis. The mean utility weights from the standard gamble were 0.857 (no gastric cancer with Helicobacter pylori infection), 0.773 (early gastric cancer [EGC] with endoscopic surgery), 0.779 (EGC with subtotal gastrectomy), 0.767 (EGC with total gastrectomy), 0.602 (advanced gastric cancer with subtotal gastrectomy and adjuvant chemotherapy), 0.643 (advanced gastric cancer with total gastrectomy and adjuvant chemotherapy), 0.522 (advanced gastric cancer with extended gastrectomy and adjuvant chemotherapy), 0.404 (metastatic gastric cancer with palliative chemotherapy), and 0.399 (recurrent gastric cancer with palliative chemotherapy).ConclusionThis study was the first to comprehensively estimate the utility weights of gastric cancer-related health states in a general population. The utility weights derived from this study could be useful for future economic evaluations related to gastric cancer interventions.

Health‐related quality of life and health utility score of patients with gastric cancer: A multi‐centre cross‐sectional survey in China

“…Areia et al found that the utility scores for patients with gastric premalignant conditions (0.79) were similar to those without gastric lesions (0.78), but decreased to 0.68 for patients with gastric cancer by using the EQ‐5D‐5L Spanish‐specific tariff (Areia et al., 2014). In another study conducted by Lee et al, participants from the general population were asked to perform standard gamble tasks to measure the utility scores of gastric cancer‐related health states (Lee, Ock, Kim, & Jo, 2018). The mean utility scores tended to decrease according to gastric cancer progression (ranging from 0.857 to 0.399).…”

Elicitation of Health Utilities in Oncology in the Kingdom of Saudi Arabia

“…It is worth noting that both studies reported the same conditions to be associated with the lowest HUs. The same study group also reported another survey of 326 patients with gastric carcinoma who had HU scores of 0.399 for recurrent gastric cancer and 0.404 9 for metastatic gastric cancer. We reported 0.298 as the mean HU for gastric cancer.…”

Economic and health impacts of introducing Helicobacter pylori eradication strategy into national gastric cancer policy in Japan: A cost‐effectiveness analysis

“…Epidemiologic parameters and clinical probabilities were collected using MEDLINE from 2000 to June 2, 2021, national census, and Japanese cancer statistics (Table 1 ). 2 , 3 , 10 , 11 , 12 , 15 , 16 , 17 , 18 , 19 , 20 We estimated annual age‐specific numbers of H. pylori ‐positive patients with eradication treatment from the literature 10 , 11 and expert opinion (Table 1 , Figure S1A ). The numbers of H. pylori ‐positive patients with and without eradication were estimated from the literature 16 and national census (Table 1 , Figure S1B ).…”

“…Health state utilities were obtained from the literature and were calculated using utility weights (Table 1 ). 25 , 26 The annual discounting of the utilities in this analysis was set at a rate of 3%. 22 , 23…”