Estimation of Porosity Effect on Mechanical Properties in Calcium Phosphate Cement Reinforced by Strontium Nitrate Nanoparticles: Fabrication and FEM Analysis

Fada, Rezvan; Shahgholi, Mohamad; Azimi, Reyhaneh; Babadi, Niusha Farhadi

doi:10.1007/s13369-023-08050-x

Cited by 17 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Investigating the effects of increased BMI on IVDD may provide valuable insight into the role of mechanical loading in disc health and disease progression, informing preventive strategies and therapeutic interventions aimed at reducing the burden of spinal disorders. Overall, these research efforts contribute to advancing our understanding of spinal biomechanics, facilitating the development of targeted interventions to reduce the impact of degenerative disc diseases, development and effect of new implant, and improve spinal health outcomes [89].…”

Section: Discussionmentioning

confidence: 99%

Validation and Estimation of Obesity-Induced Intervertebral Disc Degeneration through Subject-Specific Finite Element Modelling of Functional Spinal Units

Singh,

Verma

et al. 2024

Bioengineering

View full text Add to dashboard Cite

(1) Background: Intervertebral disc degeneration has been linked to obesity; its potential mechanical effects on the intervertebral disc remain unknown. This study aimed to develop and validate a patient-specific model of L3–L4 vertebrae and then use the model to estimate the impact of increasing body weight on disc degeneration. (2) Methods: A three-dimensional model of the functional spinal unit of L3–L4 vertebrae and its components were developed and validated. Validation was achieved by comparing the range of motions (RoM) and intradiscal pressures with the previous literature. Subsequently, the validated model was loaded according to the body mass index and estimated stress, deformation, and RoM to assess disc degeneration. (3) Results: During validation, L3–L4 RoM and intradiscal pressures: flexion 5.17° and 1.04 MPa, extension 1.54° and 0.22 MPa, lateral bending 3.36° and 0.54 MPa, axial rotation 1.14° and 0.52 MPa, respectively. When investigating the impact of weight on disc degeneration, escalating from normal weight to obesity reveals an increased RoM, by 3.44% during flexion, 22.7% during extension, 29.71% during lateral bending, and 33.2% during axial rotation, respectively. Also, stress and disc deformation elevated with increasing weight across all RoM. (4) Conclusions: The predicted mechanical responses of the developed model closely matched the validation dataset. The validated model predicts disc degeneration under increased weight and could lay the foundation for future recommendations aimed at identifying predictors of lower back pain due to disc degeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Validation and Estimation of Obesity-Induced Intervertebral Disc Degeneration through Subject-Specific Finite Element Modelling of Functional Spinal Units

Singh,

Verma

et al. 2024

Bioengineering

View full text Add to dashboard Cite

show abstract

“…Jing et al have higher values for PCL, with results around 5-7 MPa, increasing with the filling of hydroxyapatite as follows: 7-10 MPa (1%), 20-23 MPa (5%) [83]. Another alternative is bone cement such as Calcium Phosphate (CaP), whose properties can also be reinforced, as shown by Fada et al [84], by tuning the internal porosity architecture and doping the material with nanoparticles such as strontium nitrate nanoparticles (NPs). The result is a material that can be tuned by modifying the porosity and filling in a range with a strength of between 10.3 MPa and 28.5 MPa, before and after placing the samples in simulated body fluid.…”

Section: Mechanical Properties: Seeking To Mimic Real Tissuementioning

confidence: 99%

Advanced Strategies for the Fabrication of Multi-Material Anatomical Models of Complex Pediatric Oncologic Cases

Valls-Esteve,

Tejo-Otero,

Adell-Gómez

et al. 2023

Bioengineering

View full text Add to dashboard Cite

The printing and manufacturing of anatomical 3D models has gained popularity in complex surgical cases for surgical planning, simulation and training, the evaluation of anatomical relations, medical device testing and patient–professional communication. 3D models provide the haptic feedback that Virtual or Augmented Reality (VR/AR) cannot provide. However, there are many technologies and strategies for the production of 3D models. Therefore, the aim of the present study is to show and compare eight different strategies for the manufacture of surgical planning and training prototypes. The eight strategies for creating complex abdominal oncological anatomical models, based on eight common pediatric oncological cases, were developed using four common technologies (stereolithography (SLA), selectie laser sinterning (SLS), fused filament fabrication (FFF) and material jetting (MJ)) along with indirect and hybrid 3D printing methods. Nine materials were selected for their properties, with the final models assessed for application suitability, production time, viscoelastic mechanical properties (shore hardness and elastic modulus) and cost. The manufacturing and post-processing of each strategy is assessed, with times ranging from 12 h (FFF) to 61 h (hybridization of FFF and SLS), as labor times differ significantly. Cost per model variation is also significant, ranging from EUR 80 (FFF) to EUR 600 (MJ). The main limitation is the mimicry of physiological properties. Viscoelastic properties and the combination of materials, colors and textures are also substantially different according to the strategy and the intended use. It was concluded that MJ is the best overall option, although its use in hospitals is limited due to its cost. Consequently, indirect 3D printing could be a solid and cheaper alternative.

show abstract

“…As a biomineralization precursor of the bone apatite generation process, amorphous calcium phosphate (ACP) has attracted considerable attention from researchers for the design of bone regeneration materials. In previous research, thermal gravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), and vibrational spectroscopy, including Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy, were considered as valuable techniques in studying ACP particles [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Generation of Pearl/Calcium Phosphate Composite Particles and Their Integration into Porous Chitosan Scaffolds for Bone Regeneration

Li,

Ur Rehman,

Shepherd

et al. 2024

JFB

View full text Add to dashboard Cite

Bone tissue engineering using osteoconductive scaffolds holds promise for regeneration, with pearl powder gaining interest for its bioactive qualities. This study used freeze drying to create chitosan (CS) scaffolds with pearl/calcium phosphate (p/CaP) powders, mimicking bone tissue structurally and compositionally. Characterization included scanning electron microscopy (SEM) and mechanical testing. X-ray diffraction (XRD) Fourier-transform infrared–photoacoustic photo-acoustic sampling (FTIR−PAS), and FTIR- attenuated total reflectance (FTIR-ATR) were used to characterize p/CaP. In vitro tests covered degradation, cell activity, and SEM analysis. The scaffolds showed notable compressive strength and modulus enhancements with increasing p/CaP content. Porosity, ranging from 60% to 90%, decreased significantly at higher pearl/CaP ratios. Optimal cell proliferation and differentiation were observed with scaffolds containing up to 30 wt.% p/CaP, with 30 wt.% pearl powder and 30 wt.% p/CaP yielding the best results. In conclusion, pearl/calcium phosphate chitosan (p/CaP_CS) composite scaffolds emerged as promising biomaterials for bone tissue engineering, combining structural mimicry and favourable biological responses.

show abstract

Estimation of Porosity Effect on Mechanical Properties in Calcium Phosphate Cement Reinforced by Strontium Nitrate Nanoparticles: Fabrication and FEM Analysis

Cited by 17 publications

References 29 publications

Validation and Estimation of Obesity-Induced Intervertebral Disc Degeneration through Subject-Specific Finite Element Modelling of Functional Spinal Units

Validation and Estimation of Obesity-Induced Intervertebral Disc Degeneration through Subject-Specific Finite Element Modelling of Functional Spinal Units

Advanced Strategies for the Fabrication of Multi-Material Anatomical Models of Complex Pediatric Oncologic Cases

Generation of Pearl/Calcium Phosphate Composite Particles and Their Integration into Porous Chitosan Scaffolds for Bone Regeneration

Contact Info

Product

Resources

About