Estimation of Portal Venous Pressure by Occlusive Hepatic Vein Catheterization

Krook, Hans

doi:10.3109/00365515309094199

Cited by 37 publications

(9 citation statements)

References 9 publications

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“…In 1951, Myers and Taylor first used wedged hepatic venous pressure (WHVP), which estimates portal venous pressure by occlusive hepatic vein catheterization 4. Currently, a safe, reproducible and less invasive technique to measure the HVPG has been developed.…”

Section: Introductionmentioning

confidence: 99%

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Hepatic venous pressure gradient: clinical use in chronic liver disease

Suk

2014

Clin Mol Hepatol

119

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Portal hypertension is a severe consequence of chronic liver diseases and is responsible for the main clinical complications of liver cirrhosis. Hepatic venous pressure gradient (HVPG) measurement is the best available method to evaluate the presence and severity of portal hypertension. Clinically significant portal hypertension is defined as an increase in HVPG to >10 mmHg. In this condition, the complications of portal hypertension might begin to appear. HVPG measurement is increasingly used in the clinical fields, and the HVPG is a robust surrogate marker in many clinical applications such as diagnosis, risk stratification, identification of patients with hepatocellular carcinoma who are candidates for liver resection, monitoring of the efficacy of medical treatment, and assessment of progression of portal hypertension. Patients who had a reduction in HVPG of ≥20% or to ≤12 mmHg in response to drug therapy are defined as responders. Responders have a markedly decreased risk of bleeding/rebleeding, ascites, and spontaneous bacterial peritonitis, which results in improved survival. This review provides clinical use of HVPG measurement in the field of liver disease.

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Section: Introductionmentioning

confidence: 99%

“…HVPG represents the gradient between the portal vein and the hepatic vein. For many years, measuring hepatic venous pressures, both the free hepatic venous pressure (FHVP) and the WHVP, either with a wedge catheter or a balloon catheter, has been the standard approach for estimating portal venous pressure 4,5,6…”

Section: Introductionmentioning

confidence: 99%

Hepatic venous pressure gradient: clinical use in chronic liver disease

Suk

2014

Clin Mol Hepatol

119

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“…PP can be measured by direct cannulation of the portal vein or its tributaries. The PP obtained by this method has a good correlation with HVPG . Most surgical centers in northern India use an omental vein or the gastroepiploic vein to measure PP during abdominal operations.…”

Section: Discussionmentioning

confidence: 85%

Correlations of portal pressure in post‐cholecystectomy benign biliary stricture

Nag

Arora

Tyagi

et al. 2015

Hepatology Research

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Aim: Presence of portal hypertension (PH) adversely affects perioperative and long-term outcome in patients with postcholecystectomy benign biliary stricture (PCBBS). Identification of factors related to the development of PH will help to prevent this complication.Methods: From September 2010 to December 2012 patients with PCBBS were studied prospectively for correlation of portal pressure (PP) with injury repair interval (IRI), biliary pressure (BP), severity of hepatic fibrosis (FS), severity of hepatic inflammation (IS) and obstructive biliary pathology score (OBPS). Appropriate statistical methods employed and P 2 0.05 (two-sided) was considered statistically significant. Spearman's rank correlation coefficients (P-value) of FS with IS and OBPS were 0.561 (0.003) and 0.371 (0.04), respectively. Spearman's rank correlation coefficient of serum bilirubin with OBPS was 0.550 (P = 0.001). Incidence of PH was 33.3% and mean fall of PP following biliary repair was 6.2 1 1.98 mmHg (P < 0.0001).Conclusion: PP in patients with PCBBS has a good correlation with IS, and a fair correlation with both FS and IRI whereas PP was not directly related to BP and OBPS; further prospective trials are mandatory to confirm this correlation, and to evaluate mechanism of fall in PP following biliary decompression.

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“…In subjects with normal livers, P Wedge and P Free are about 6 and 4 mm Hg, respectively [80-82]. Since direct measurement of P A in normal subjects with no overt ascites is difficult, indirect approaches have been employed [83].…”

Section: Discussionmentioning

confidence: 99%

Quantitative modeling of the physiology of ascites in portal hypertension

Levitt

2012

BMC Gastroenterol

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Although the factors involved in cirrhotic ascites have been studied for a century, a number of observations are not understood, including the action of diuretics in the treatment of ascites and the ability of the plasma-ascitic albumin gradient to diagnose portal hypertension. This communication presents an explanation of ascites based solely on pathophysiological alterations within the peritoneal cavity. A quantitative model is described based on experimental vascular and intraperitoneal pressures, lymph flow, and peritoneal space compliance. The model's predictions accurately mimic clinical observations in ascites, including the magnitude and time course of changes observed following paracentesis or diuretic therapy.

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Estimation of Portal Venous Pressure by Occlusive Hepatic Vein Catheterization

Abstract: Scand J Clin Lab Invest Downloaded from informahealthcare.com by Chulalongkorn University on 12/26/14For personal use only.

Cited by 37 publications

References 9 publications

Hepatic venous pressure gradient: clinical use in chronic liver disease

Hepatic venous pressure gradient: clinical use in chronic liver disease

Correlations of portal pressure in post‐cholecystectomy benign biliary stricture

Quantitative modeling of the physiology of ascites in portal hypertension

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