Estimation of Pyruvic acid in serum and saliva among healthy and potentially malignant disorder subjects - a stepping stone for cancer screening?

Abstract

Background According to Warburg’s effect, the rate of glycolysis increases in cancerous cells. This will increase overall levels of pyruvic acid. The present on-going study was conducted to estimate the levels of pyruvic acid in saliva and serum in normal, oral PMD subjects. Material and Methods A total of 50 subjects in healthy, PMD of the oral cavity individuals were selected based on clinical and histological criteria. Collected saliva and serum samples were subjected to pyruvic acid level estimation using biochemical analysis. Results Of the 50 participants 25 (13: Males; 12: Females) & 25 (16: Males; 9: Females) were PMD group. Independent samples t test showed statistically significant difference in serum & salivary pyruvic acid level in between 2 groups (p < 0.001 respectively). Conclusions Estimation of pyruvic acid showed sequential increase in the level in PMD group compared to healthy. Hence the study results open new direction in cancer screening. Key words:Pyruvic acid, glycolysis, warburg’s effect.

Pyruvic acid levels in serum and saliva: A new course for oral cancer screening?

“…Salivary pyruvic acid level for healthy individuals was found to be 1.46 ± 0.64,[ 12 ] which is in parallel with this study (1.32 ± 0.10). This is slightly higher than the serum levels, one of the reasons may be the presence of oral bacteria.…”

“…[ 9 ] However, whether the increase of glycolytic activity in cancer cells is mainly due to inherent metabolic alterations or due to the anaerobic environment in the tumor tissues remains controversial[ 10 11 ] Potentially malignant disorders also showed a significant increase of pyruvic acid levels. [ 12 ] Hence, there is a chance of imbalance in the production and excretion of the pyruvic acid in the local and systemic aspects of oral cancer subjects.…”

Recognizing the salivary panomics for the clinical application in oral potentially malignant disorders

“…The results are tabulated in Tables 1 and 2 . [ 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 ]…”

Estimation of serum pyruvic acid levels in oral squamous cell carcinoma

“…Similarly, Bhat et al . [ 29 ] estimated the serum pyruvic acid levels in healthy and potentially malignant disorder (PMD) subjects and concluded that there was a significant rise in serum pyruvic acid levels in PMD subjects compared to healthy individuals, indicating that estimation of serum pyruvic acid can be a screening tool for PMD and malignant diseases.…”