Estimation of Quinolones, Ceftiofur, and Thiamphenicol Residues Levels in Honey

Morariu, Ionela Daniela

doi:10.31925/farmacia.2021.3.14

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…Recently, high-resolution mass spectrometry (HR-MS/MS) has been applied to the elucidation of the structures of various known and unknown compounds [18,19]. High mass spectral resolving power (RP), which reduces interference, and high mass accuracy, which allows the prediction of molecular formula for spectral peaks, have been proven to be powerful tools for the identification of new chemicals.…”

Section: Mass Spectrometric Structural Confirmation Of the Active Com...mentioning

confidence: 99%

Chitosan Microparticles Loaded with New Non-Cytotoxic Isoniazid Derivatives for the Treatment of Tuberculosis: In Vitro and In Vivo Studies

Dragostin

Iacob

et al. 2022

Polymers

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Lately, in the world of medicine, the use of polymers for the development of innovative therapies seems to be a major concern among researchers. In our case, as a continuation of the research that has been developed so far regarding obtaining new isoniazid (INH) derivatives for tuberculosis treatment, this work aimed to test the ability of the encapsulation method to reduce the toxicity of the drug, isoniazid and its new derivatives. To achieve this goal, the following methods were applied: a structural confirmation of isoniazid derivatives using LC-HRMS/MS; the obtaining of microparticles based on polymeric support; the determination of their loading and biodegradation capacities; in vitro biocompatibility using MTT cell viability assays; and, last but not least, in vivo toxicological screening for the determination of chronic toxicity in laboratory mice, including the performance of a histopathological study and testing for liver enzymes. The results showed a significant reduction in tissue alterations, the disappearance of cell necrosis and microvesicular steatosis areas and lower values of the liver enzymes TGO, TGP and alkaline phosphatase when using encapsulated forms of drugs. In conclusion, the encapsulation of INH and INH derivatives with chitosan had beneficial effects, suggesting a reduction in hepatotoxicity and, therefore, the achievement of the aim of this paper.

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Section: Mass Spectrometric Structural Confirmation Of the Active Com...mentioning

confidence: 99%

Chitosan Microparticles Loaded with New Non-Cytotoxic Isoniazid Derivatives for the Treatment of Tuberculosis: In Vitro and In Vivo Studies

Dragostin

Iacob

et al. 2022

Polymers

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“…Streptomycin, erythromycin, lincomycin, sulfonamide, and chloramphenicol are other antibiotics beekeepers use [57,[70][71][72].…”

Section: Antibioticsmentioning

confidence: 99%

“…Te determination of residues in honey demonstrated the presence of enrofoxacin, ciprofoxacin, and norfoxacin. Because they can trigger allergic reactions or the development of drug resistance in humans, quinolones used in veterinary medicine may pose a risk to human health [65,71,78].…”

Section: Antibioticsmentioning

confidence: 99%

A Comprehensive Narrative Review on the Hazards of Bee Honey Adulteration and Contamination

Morariu,

Avasilcai,

Vieriu

et al. 2024

Journal of Food Quality

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Honey bees are renowned for producing a remarkable substance known as bee honey, which stands as a functional food celebrated for its numerous health benefits. This natural wonder possesses a spectrum of advantageous properties, including anti-inflammatory, antioxidant, analgesic, antibacterial, and wound-healing qualities. However, in our modern era of heightened utilization of bee products, a new and pressing global health concern has emerged—the contamination of honey with pesticides, antibiotics, microorganisms, and heavy metals. The consumption of beekeeping products containing pesticide residues has been linked to a range of health issues, including genetic malformations, cellular degradation, allergic reactions, and even potential carcinogenic effects. Troublingly, documented cases exist of botulism in newborns resulting from the ingestion of contaminated honey. Additionally, the use of antibiotics in beekeeping practices has been associated with the concerning emergence of antibiotic resistance. This comprehensive review sheds light on the substantial consequences of honey contamination for human health. It underscores the urgent need for the establishment of a rigorous monitoring system, the validation of minimum acceptable pollutant levels, and, at the very least, the regulation of maximum residue limits for bee products, with a particular emphasis on bee honey.

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“…Inappropriate beekeeping practices such as giving antibiotics as a treatment can also cause residues in honey, which adversely affect human health [ 62 ]. From previous studies that have been carried out, honey detection using the biochip technology method is one of the antibiotic analyzers that can work simultaneously, quickly and cost-effectively [ 44 , 63 ]. The result of the analysis obtained is confirmed using the validation of the LC-MS/MS method.…”

Section: Drug Residues In Foodmentioning

confidence: 99%

Recent Advances in the Determination of Veterinary Drug Residues in Food

Pratiwi,

Ramadhanti,

Amatulloh

et al. 2023

Foods

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The presence of drug residues in food products has become a growing concern because of the adverse health risks and regulatory implications. Drug residues in food refer to the presence of pharmaceutical compounds or their metabolites in products such as meat, fish, eggs, poultry and ready-to-eat foods, which are intended for human consumption. These residues can come from the use of drugs in the field of veterinary medicine, such as antibiotics, antiparasitic agents, growth promoters and other veterinary drugs given to livestock and aquaculture with the aim of providing them as prophylaxis, therapy and for promoting growth. Various analytical techniques are used for this purpose to control the maximum residue limit. Compliance with the maximum residue limit is very important for food manufacturers according to the Food and Drug Administration (FDA) or European Union (EU) regulations. Effective monitoring and control of drug residues in food requires continuous advances in analytical techniques. Few studies have been reviewed on sample extraction and preparation techniques as well as challenges and future directions for the determination of veterinary drug residues in food. This current review focuses on the overview of regulations, classifications and types of food, as well as the latest analytical methods that have been used in recent years (2020–2023) for the determination of drug residues in food so that appropriate methods and accurate results can be used. The results show that chromatography is still a widely used technique for the determination of drug residue in food. Other approaches have been developed including immunoassay, biosensors, electrophoresis and molecular-based methods. This review provides a new development method that has been used to control veterinary drug residue limit in food.

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Estimation of Quinolones, Ceftiofur, and Thiamphenicol Residues Levels in Honey

Cited by 3 publications

References 24 publications

Chitosan Microparticles Loaded with New Non-Cytotoxic Isoniazid Derivatives for the Treatment of Tuberculosis: In Vitro and In Vivo Studies

Chitosan Microparticles Loaded with New Non-Cytotoxic Isoniazid Derivatives for the Treatment of Tuberculosis: In Vitro and In Vivo Studies

A Comprehensive Narrative Review on the Hazards of Bee Honey Adulteration and Contamination

Recent Advances in the Determination of Veterinary Drug Residues in Food

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