Estimation of Serum Ferritin Level in Preterm Labour

El-Shahawy, Hazem F; Hendawy, Sherif F.; Hassanin, Alaa S.; El-Azeem, Mona M. Abd

doi:10.12816/0039690

Cited by 3 publications

(5 citation statements)

References 8 publications

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“…Besides, Khambalia et al revealed that high maternal ferritin level in the early time of pregnancy (12 weeks of gestation) was associated with an increased risk of preterm delivery (23). El-Shahawy et al also showed that ferritin level was significantly higher in the preterm group at 30-34 weeks than in uncomplicated pregnancies at the same age of gestation, and ferritin level above 55 ng/mL with a sensitivity of 96.7% and specificity of 96.7% could be used as a predictor of preterm delivery (15). Finally, Abdel-Malek et al showed that serum ferritin level at week 30 of gestation was significantly higher in the preterm group (76.3±29.4 ng/mL) than in the control group (20.2±5.0 ng/mL).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the above studies, which determine a cutoff point for ferritin level for predicting preterm labor, several studies have addressed the predictive role of ferritin in preterm delivery (14,15,(21)(22)(23). Singh et al reported that ferritin was a better predicting biomarker for preterm delivery than other indicators (22).…”

Section: Discussionmentioning

confidence: 99%

“…Maternal subclinical infection may increase ferritin level as an acute phase reactant and cause spontaneous rupture of the membranes (13). Some studies have reported that ferritin level could be used as a predictor of preterm delivery (14)(15)(16); however, the results of studies in this area are controversial.…”

Section: Key Pointmentioning

confidence: 99%

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Comparison of serum ferritin levels in pregnant women with preterm and term deliveries

2020

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Introduction: Despite high rates of mortality and morbidity due to preterm delivery, none of the diagnostic and biochemical tests could help to accurately identify the cases at risk of preterm delivery. Objectives: Since ferritin is an acute phase reactant, this study aimed to evaluate serum ferritin levels in women with preterm and term delivery. Methods: This study was conducted on 150 women with preterm delivery (50 cases in each of the groups 24-30, 30-34, and 34-37 weeks of pregnancy), 150 women with term delivery, and 150 pregnant women who were between 24-37 weeks of pregnancy (same as preterm delivery groups). Results: The mean ferritin level in all preterm groups was significantly higher than that in the term group, but there was no difference among the preterm groups. In addition, ferritin level in each preterm group was significantly higher than those in the normal pregnancy group at the same gestational age. In preterm deliveries, ferritin levels were significantly higher in cases with prelabor rupture of membranes (PROM) or with a prolonged leakage (longer than 12 hours). In addition, in patients with PROM or prolonged leakage, ferritin levels were significantly higher in preterm deliveries than in term deliveries. A ferritin level of 37.5 ng/mL recognized as the best cut-off for preterm delivery, as compared with term delivery, and its sensitivity, specificity, and diagnostic accuracy was 78.7%, 68.7%, and 73.6%, respectively. Conclusion: The findings of the present study showed that serum ferritin level can be used to find patients at risk of preterm delivery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of serum ferritin levels in pregnant women with preterm and term deliveries

2020

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“…Our findings weren't coincides with Elnasr and Ammar, [13] who demonstrated that the AUC for s-ferritin is 0.97, the cutoff value 110.5 ng/ml with sensitivity 86.7%, Specificity 94.1% and 95% CI 0.94-1.0. Also, El-Shahawy et al, [14] conducted (ROC) curves which were constructed for s-ferritin as predictor of pre-term labor. Sferritin was a highly significant predictor of pre-term delivery and more than 55 ng/mL was the optimal cut-off point.…”

Section: Discussionmentioning

confidence: 99%

Serum Ferritin Levels in Pregnant Women with Preterm and Term Deliveries

2023

Al-Azhar University Journal of Virus Researches and Studies

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The measuring serum ferritin level as a sensitive inflammatory biomarker might effectively predict preterm delivery, but the power and the best cut-off point of this biomarker for predicting preterm labor in Egyptian population has not been substantially identified. This study aimed to evaluate serum ferritin levels in women with preterm and term delivery. This case control study was conducted on 90 gravid females who allocated into 2 groups: Group A: It comprised 60 cases with labor pain registered into 4 groups with a GA of 24 to 30 weeks, 30 to 34 weeks, 34 to 37 weeks, and >37 weeks (study group) and Group B: It included 30 cases who were in comparable GAs (control group) at Obstetrics and gynecology dep. at Al-Zahraa University hospitals. In this table, in preterm deliveries, ferritin levels were significantly higher (P< 0.05) in patients with PROM or a prolonged leakage; however, in term deliveries, there was no significant difference in ferritin level between patients with and without PROM or a prolonged leakage. In addition, ferritin levels were significantly higher in preterm deliveries than term deliveries in patients with PROM or a prolonged leakage (p<0.001). ROC-curve showed that the cutoff value of s-ferritin was 37.5 ng/ml with 79.5% and 84.3% sensitivity and specificity resp. for pre-and in-term delivery groups. The findings of the present study showed that serum ferritin level can be used to find patients at risk of preterm delivery.

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“…The time of viability varies the newborn (TTN), neonatal jaundice, respiratory distress syndrome (RDS), necrotizing enterocolitis (NEC), sepsis, and prolonged NICU stay. 1 Each year, 15 million preterm births are predicted to occur, with 1.1 million newborns dying as a result of preterm birth complications. Preterm birth prevention is the single most critical problem facing modern obstetrics today, yet progress has been limited by a lack of knowledge of the core mechanisms that cause early labour and delivery.…”

Section: Introductionmentioning

confidence: 99%

Study of serum ferritin levels in preterm labour and its perinatal outcome in tertiary care centre

Kiranmai,

Munagavalasa,

Bhargavi

et al. 2024

PJMS

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Pregnant women at risk of preterm birth may be easily identified and sent to tertiary care centres for further therapy. Numerous biomarkers are being investigated for their ability to predict preterm labour; serum ferritin is one of these indicators. It is an intracellular protein that has a role in iron storage and is also an acute phase reactant that is increased during acute and chronic infections. To evaluate serum ferritin levels in preterm labour and perinatal outcome in a tertiary care centre during 2 years.A case control study was conducted in collaboration with the Department of Obstetrics and Gynecology at Osmania Medical College, Hyderabad, from 2019 to 2022. After receiving permission, one hundred participants with an average age of 25 years who visit Niloufer hospital are included in the research and separated into case (Group 1) and control (Group 2) groups. Group 1 consists of women who had spontaneous preterm labour, whereas Group 2 consists of pregnant women of the same gestational age who are considered controls. Among 50 instances of preterm labour, 39 (78.0 percent) were classified as preterm (32 to 36 weeks), whereas 11 (22.0 percent) were classified as very preterm (28 to 32 weeks). The majority of the 50 patients included in the research, 31 (62.0 percent), were born by normal vaginal delivery, while 19 (38.0 percent) were delivered using emergency LSCS. CRP was positive in two patients (4.0 percent). The mean WBC levels in cases were much greater than those in controls, and the difference is statistically significant. Serum ferritin levels were 40.298 19.64 in cases and 20.343 6.82 in controls. Serum ferritin levels were substantially higher in cases than in controls on average. The mean WBC levels were greatest in extremely preterm infants, followed by preterm infants; however, this difference was determined to be statistically insignificant. Ferritin levels are much higher in preterm labour patients than in low-risk women of the same gestational age. Serum ferritin levels may be utilised as a biomarker in high-risk premature labour.

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Estimation of Serum Ferritin Level in Preterm Labour

Cited by 3 publications

References 8 publications

Comparison of serum ferritin levels in pregnant women with preterm and term deliveries

Comparison of serum ferritin levels in pregnant women with preterm and term deliveries

Serum Ferritin Levels in Pregnant Women with Preterm and Term Deliveries

Study of serum ferritin levels in preterm labour and its perinatal outcome in tertiary care centre

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