Estimation of Serum Glutathione Peroxidase in Streptozotocin Induced Diabetic Rat Treated with Bitter Leaf Extract

Nwakulite, Arvin; Obeagu, Emmanuel Ifeanyi; Eze, Richard; Ugochi, Valerie E.; Vincent, C. C. N.; Okafor, Chukwuma J.; Chukwurah, Ejike Felix; Unaeze, Bright Chukwuebuka; Amaechi, Chukwudi Ofodile; Okwuanaso, Chetachi Blessing; Chukwuani, Ufuoma; Ifionu, Bart I.

doi:10.9734/jpri/2021/v33i30b31655

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…The intricate dance between oxidative stress and pregnancy outcomes has drawn substantial attention in recent years, prompting exploration into interventions that might mitigate its detrimental effects. Antioxidants, renowned for their ability to neutralize ROS and preserve cellular integrity, stand as a potential therapeutic avenue to enhance pregnancy outcomes [11][12][13][14][15][16][17][18][19][20]. This paper aims to elucidate the multifaceted relationship between oxidative stress and pregnancy complications while exploring the role of antioxidants in ameliorating adverse outcomes.…”

Section: Introductionmentioning

confidence: 99%

The Role of Antioxidants in Improving Pregnancy Outcomes

Obeagu,

Ugwu

et al. 2024

IAA-JAS

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Pregnancy is a physiologically demanding phase marked by profound changes that elevate oxidative stress levels, posing potential risks to maternal and fetal health. Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms, has been implicated in various pregnancy complications. Antioxidants, renowned for their ability to counteract ROS and mitigate cellular damage, have emerged as a potential intervention to ameliorate adverse outcomes during pregnancy. The paper highlights the physiological changes in pregnancy that contribute to heightened oxidative stress, emphasizing the link between oxidative stress and complications such as pre-eclampsia, gestational diabetes, preterm birth, and intrauterine growth restriction. This paper emphasizes the imperative for robust, well-designed clinical trials to elucidate the optimal timing, dosages, and formulations of antioxidants in pregnancy. It calls for a comprehensive approach to establish clear guidelines and recommendations for antioxidant supplementation. In conclusion, this review underscores the potential of antioxidants as a promising intervention to mitigate oxidative stress-related pregnancy complications. However, the inconclusive nature of current evidence necessitates further rigorous research endeavors. Through this exploration, it accentuates the urgency for standardized protocols, ethical considerations, and extensive clinical studies to unlock the full potential of antioxidants in improving maternal and fetal health outcomes during pregnancy. Keywords: Antioxidants, Pregnancy, Maternal Health, Fetal Health, Oxidative Stress, Reactive Oxygen Species (ROS), Preeclampsia, Gestational Diabetes, Fetal Development

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Section: Introductionmentioning

confidence: 99%

The Role of Antioxidants in Improving Pregnancy Outcomes

Obeagu,

Ugwu

et al. 2024

IAA-JAS

View full text Add to dashboard Cite

show abstract

“…Numerous pregnancy issues have been linked to oxidative stress, which is caused by an imbalance between the body's antioxidant defense mechanisms and reactive oxygen species (ROS). Because it serves as a crucial interface between the mother and the fetus, the placenta is especially vulnerable to oxidative damage, which could compromise its functions and have an adverse influence on fetal development (11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Enhancing pregnancy outcomes: the role of antioxidants in obstetrics

E.I,

G.U.,

P.M.

2023

KJHS

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The physiological process of pregnancy is intricate and fraught with difficulties and potential problems that may affect the health of the mother and the fetus. Owing to its capacity to counteract oxidative stress, antioxidants have drawn a lot of interest from obstetricians as possible partners in enhancing pregnancy outcomes. This study examines the body of research on the function of antioxidants in obstetrics and how they affect different elements of pregnancy. Reactive oxygen species (ROS) and the body's antioxidant defense mechanisms are out of balance, and this imbalance can lead to oxidative stress, which has been linked to harmful pregnancy outcomes such as preterm birth, preeclampsia, and intrauterine growth restriction. One vital organ for fetal development, the placenta, is especially vulnerable to oxidative damage, which could result in difficulties. This review focuses on the many endogenous and exogenous sources of antioxidants as well as their methods of action in reducing oxidative stress in pregnancy. Selenium, polyphenols from fruits and vegetables, vitamins C and E, and other well researched antioxidants have demonstrated the potential to lower the risk of unfavorable pregnancy outcomes. The review also investigates the possible synergistic benefits of mixing several antioxidants for improved defense.

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Antioxidants and Pregnancy Complications: Exploring Therapeutic Strategies for Better Outcomes

Emmanuel Ifeanyi

2024

Clin J Obstet Gynecol

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Pregnancy complications present significant challenges, impacting maternal health and fetal development. Oxidative stress, a key contributor to various pregnancy-related disorders such as preeclampsia, gestational diabetes mellitus (GDM), and preterm birth, has spurred interest in exploring antioxidant interventions. Antioxidants, known for their ability to counteract oxidative damage, have emerged as potential therapeutic agents to mitigate these complications. This paper synthesizes current knowledge on the role of antioxidants in pregnancy, elucidating their mechanisms of action, sources, and impact on oxidative stress-related complications. It examines diverse antioxidant compounds, including vitamins C and E, selenium, and natural phytochemicals, highlighting their potential to modulate oxidative stress pathways and promote maternal-fetal well-being. Furthermore, this paper critically analyzes clinical studies, meta-analyses, and preclinical research exploring the efficacy and safety of antioxidant supplementation during pregnancy. It discusses the complexities surrounding optimal dosages, timing, and formulations of antioxidants, aiming to delineate strategies for their integration into prenatal care. In conclusion, this review provides insights into the promising role of antioxidants as therapeutic strategies to alleviate pregnancy complications associated with oxidative stress. It highlights avenues for future research, advocating for a deeper understanding of antioxidant mechanisms and their optimal utilization in prenatal care to enhance maternal and fetal health outcomes.

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Estimation of Serum Glutathione Peroxidase in Streptozotocin Induced Diabetic Rat Treated with Bitter Leaf Extract

Cited by 3 publications

References 7 publications

The Role of Antioxidants in Improving Pregnancy Outcomes

The Role of Antioxidants in Improving Pregnancy Outcomes

Enhancing pregnancy outcomes: the role of antioxidants in obstetrics

Antioxidants and Pregnancy Complications: Exploring Therapeutic Strategies for Better Outcomes

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