Estimation of skeletal muscle mass by bioimpedance and differences among skeletal muscle mass indices for assessing sarcopenia

Xu, Hong-qi; Liu, Jingmin; Zhang, Xin; Xue, Yong-tai; Shi, Jing; Chen, Wei; Xiulin, Zheng

doi:10.1016/j.clnu.2020.10.021

Cited by 19 publications

(23 citation statements)

References 45 publications

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“…The current study also revealed an epigenetic effect of treatment with a VLCKD on genes associated with muscle development such as CACNA1H, LAMA2, SMTN, SGCB, ZFHX3, CENPF, AEBP1, and CHAT. Muscle is an important tissue in the pathogenesis of obesity, which is directly linked with morbidity and mortality in humans [59,62,63]. It has been demonstrated that a VLCKD is able to preserve the mass and function of muscle [18], as well as modulate the secretion of specific myokines [61].…”

Section: Discussionmentioning

confidence: 99%

Epigenetic landscape in blood leukocytes following ketosis and weight loss induced by a very low calorie ketogenic diet (VLCKD) in patients with obesity

et al. 2021

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Background: The molecular mechanisms underlying the potential health benefits of a ketogenic diet are unknown and could be mediated by epigenetic mechanisms. Objective: To identify the changes in the obesity-related methylome that are mediated by the induced weight loss or are dependent on ketosis in subjects with obesity underwent a very-low calorie ketogenic diet (VLCKD). Methods: Twenty-one patients with obesity (n ¼ 12 women, 47.9 ± 1.02 yr, 33.0 ± 0.2 kg/m 2 ) after 6 months on a VLCKD and 12 normal weight volunteers (n ¼ 6 women, 50.3 ± 6.2 yrs, 22.7 ± 1.5 kg/m 2 ) were studied. Data from the Infinium MethylationEPIC BeadChip methylomes of blood leukocytes were obtained at time points of ketotic phases (basal, maximum ketosis, and out of ketosis) during VLCKD (n ¼ 10) and at baseline in volunteers (n ¼ 12). Results were further validated by pyrosequencing in representative cohort of patients on a VLCKD (n ¼ 18) and correlated with gene expression. Results: After weight reduction by VLCKD, differences were found at 988 CpG sites (786 unique genes). The VLCKD altered methylation levels in patients with obesity had high resemblance with those from normal weight volunteers and was concomitant with a downregulation of DNA methyltransferases (DNMT)1, 3a and 3b. Most of the encoded genes were involved in metabolic processes, protein metabolism, and muscle, organ, and skeletal system development. Novel genes representing the top scoring associated events were identified, including ZNF331, FGFRL1 (VLCKD-induced weight loss) and CBFA2T3, C3orf38, JSRP1, and LRFN4 (VLCKD-induced ketosis). Interestingly, ZNF331 and FGFRL1 were validated in an independent cohort and inversely correlated with gene expression. Conclusions: The beneficial effects of VLCKD therapy on obesity involve a methylome more suggestive of normal weight that could be mainly mediated by the VLCKD-induced ketosis rather than weight loss.

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Section: Discussionmentioning

confidence: 99%

Epigenetic landscape in blood leukocytes following ketosis and weight loss induced by a very low calorie ketogenic diet (VLCKD) in patients with obesity

et al. 2021

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“…This type of device enabled analysis of the whole body, and thereby the calculation of skeletal muscle mass, taking segmental muscle mass into account. SP was defined as skeletal muscle mass (SMM) to BMI ratio (SMM/BMI) of 1.05 kg/ kg/m 2 cut-off for men or 0.71 kg/kg/m 2 for women [17]. The study population was divided in five groups according to: 1) obesity, 2) WC, 3) MS, 4) fat distribution based on BIA and 5) SP.…”

Section: Clinical Definitions Classifications and Outcomesmentioning

confidence: 99%

The impact of body composition on mortality of COVID-19 hospitalized patients: A prospective study on abdominal fat, obesity paradox and sarcopenia

Graziano

Peghin

Martino

et al. 2022

Clinical Nutrition ESPEN

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“…A possible explanation for the variation in prevalence rates of sarcopenia between both studies of Chinese populations could be attributed to differences of mean age and the diagnostic criterion methods used to assess muscle mass. It has been reported that muscle mass assessed by the BIA method is highly dependent on the degree of muscle mass 27,28 since, the BIA method tends to overestimate it among participants with a high muscle mass and underestimate it in those with a low muscle mass. This could possibly be attributed to a higher prevalence of sarcopenia among the older populations in China.…”

Section: Discussionmentioning

confidence: 99%

Assessments of sarcopenia and its associated factors in community-dwelling middle-aged and older adults in Kelantan, Malaysia

Foo

Wen

Kadir

2023

Preprint

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Sarcopenia is considered to be an emerging public health problem worldwide, but very limited information concerning exits the influence of lifestyle factors and blood inflammation levels on sarcopenia among community-dwelling older populations in Asia, including Malaysia. A total of 230 apparently healthy community-dwelling Chinese middle-aged and older adults were included in the study. Validated questionnaires were used to assess dietary and lifestyle practices, while pro-inflammatory cytokine status was assessed by blood interleukin-6 concentrations (IL-6). Sarcopenia risk was assessed by the newly revised diagnostic criteria of the Asian Working Group for Sarcopenia. The prevalence of sarcopenia was 12.5% with similar pattern found between males and females. Multivariate logistic regression analysis showed that older age and higher concentrations of pro-inflammatory cytokine levels of IL-6 were significantly associated with a greater risk of sarcopenia, after adjustments for potential known biological and body composition factors. The present findings indicate that older adults aged 70 years and above with higher inflammation levels had a significantly increased risk of sarcopenia. Hence, effective dietary and lifestyle intervention strategies should emphasize reducing the inflammation associated with aging to prevent the rapid loss of muscle mass and strength that can lead to sarcopenia.

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Estimation of skeletal muscle mass by bioimpedance and differences among skeletal muscle mass indices for assessing sarcopenia

Cited by 19 publications

References 45 publications

Epigenetic landscape in blood leukocytes following ketosis and weight loss induced by a very low calorie ketogenic diet (VLCKD) in patients with obesity

Epigenetic landscape in blood leukocytes following ketosis and weight loss induced by a very low calorie ketogenic diet (VLCKD) in patients with obesity

The impact of body composition on mortality of COVID-19 hospitalized patients: A prospective study on abdominal fat, obesity paradox and sarcopenia

Assessments of sarcopenia and its associated factors in community-dwelling middle-aged and older adults in Kelantan, Malaysia

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