Estimation of superoxide dismutase levels in chronic periodontitis patients: A clinical and biochemical study

Kale, Rahul; Samad, Abdul; Sumanth, S; Baliga, Sharmila; Khajehnoori, Mohammed; Muglikar, Sangeeta

doi:10.4103/2249-9725.117442

Cited by 1 publication

(2 citation statements)

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“…Accordingly, as a part of the present study, SOD concentrations in the plasma of patients with periodontitis were compared with that in healthy controls, and the effect of periodontal therapy on the levels of this marker in plasma was assessed. Similar investigations were conducted by Kale et al [56] and Wei et al [25], who reported a statistically significant increase in plasma SOD concentrations in patients with periodontal disease, which declined following periodontal therapy in the cohort examined by Wei et al [25]. On the other hand, Sudhakar et al noted an increase in plasma SOD upon therapy completion, which was statistically significant in the group that also took vitamin E supplements [57].…”

Section: Discussionsupporting

confidence: 61%

“…It is likely that these discrepancies arise not only from the methodological differences but also from the extent of the periodontal disease in the group that underwent therapy. Namely, our patients had a significantly lower degree of periodontium destruction than the patients who were the focus of research conducted by Kale et al [56] and Wei et al [25]. This difference, in our opinion, could have led to significantly higher SOD values in the aforementioned studies because these authors emphasized the important influence of periodontal pocket depth on plasma SOD values.…”

Section: Discussionmentioning

confidence: 61%

See 1 more Smart Citation

Effect of Nonsurgical Periodontal Treatment on Salivary and Plasma Superoxide Dismutase Levels of Patients Suffering from Periodontitis

Veljovic,

Djuric,

Mirnic

et al. 2023

JCM

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Antioxidant capacity is frequently measured by evaluating superoxide dismutase (SOD) concentration in body fluids. The aim of this study was to compare SOD concentrations in the saliva and plasma of patients with periodontitis to those measured in a group of patients with healthy periodontium, as well as to evaluate the influence of nonsurgical periodontal therapy on salivary and plasma SOD in periodontitis patients. For this purpose, 40 systemically healthy patients aged 30–70 years who had at least 20 teeth were recruited, 20 of whom had periodontitis, and 20 served as healthy periodontitis-free controls. In all participants, periodontal status was assessed via the plaque index (PI), gingival index (GI), papilla bleeding index (PIB), probing depth (PD), and clinical attachment level (CAL), and the SOD concentration in both saliva and plasma was determined by conducting a commercial immunoenzymatic ELISA test. In periodontitis patients, periodontal indices and saliva and blood samples were taken at the beginning of the study, as well as 3 months after periodontal therapy, while in the control group, these data were gathered at the beginning of the study only. SOD values in the saliva of patients with periodontitis (0.244 U/µL) were statistically significantly higher compared with patients with healthy periodontium (0.017 U/µL). Moreover, periodontal therapy led to a statistically significant decrease in this marker in the saliva of patients with periodontitis (p = 0.023), which was comparable with that measured in the control group. On the other hand, no statistically significant differences were noted in plasma SOD values either between the two groups or at follow-up compared with baseline in the group with periodontitis. These findings suggest that the elevated salivary SOD in patients with periodontal disease may represent a mechanism of tissue protection against oxidative stress that occurs in response to periodontal disease.

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