Estimation of surface charges in some biological membranes

Lakshminarayanaiah, N.; Murayama, Koichi

doi:10.1007/bf01870254

Cited by 23 publications

(17 citation statements)

References 29 publications

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“…IV E and IV F for details). This result is consistent with the surface charge density range of 0.002-0.37 C=m 2 that was measured in neural cells [41].…”

Section: Experimental Validation and Inferencesupporting

confidence: 92%

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Thermal Transients Excite Neurons through Universal Intramembrane Mechanoelectrical Effects

et al. 2018

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Modern advances in neurotechnology rely on effectively harnessing physical tools and insights towards remote neural control, thereby creating major new scientific and therapeutic opportunities. Specifically, rapid temperature pulses were shown to increase membrane capacitance, causing capacitive currents that explain neural excitation, but the underlying biophysics is not well understood. Here, we show that an intramembrane thermal-mechanical effect wherein the phospholipid bilayer undergoes axial narrowing and lateral expansion accurately predicts a potentially universal thermal capacitance increase rate of ∼0.3%=°C. This capacitance increase and concurrent changes in the surface charge related fields lead to predictable exciting ionic displacement currents. The new MechanoElectrical Thermal Activation theory's predictions provide an excellent agreement with multiple experimental results and indirect estimates of latent biophysical quantities. Our results further highlight the role of electro-mechanics in neural excitation; they may also help illuminate subthreshold and novel physical cellular effects, and could potentially lead to advanced new methods for neural control.

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“…IV E and IV F for details). This result is consistent with the surface charge density range of 0.002-0.37 C=m 2 that was measured in neural cells [41].…”

Section: Experimental Validation and Inferencesupporting

confidence: 92%

“…IV E and Ref. [27]), specifically allowing for the PAINTS experiment to estimate a surface charge difference that was found to be in accord with empirical values for neural cells [41].…”

Section: Discussionmentioning

confidence: 62%

Thermal Transients Excite Neurons through Universal Intramembrane Mechanoelectrical Effects

et al. 2018

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“…and, when the sign of the surface charge of are equal (Figure 5b We will look for a solution of equations (14), in accordance with the boundary conditions (17), in the form: …”

Section: Lateral Diffusion and Drift Of Transmembrane Proteins Imentioning

confidence: 99%

“…We will not go into all the papers, we refer only to [17] and [18], where the experimental data of the surface charge of cell membranes obtained by different methods; Range of obtained values of the surface charge density is quite broad:…”

Section: Introductionmentioning

confidence: 99%

“…Recently, several experimental studies had been performed, which showed that a relatively weak microwave radiation with intensities of 0.01-1W/m2 in the range of 50-100 GHz leads to the spontaneous excitation of neural activity (see, for example, [17]). The interaction of microwave radiation with a nerve fiber was studied in [21] on the example of the mouse cerebral cortex, placed in the cerebrospinal fluid (CSF) solution and illuminated by plane-polarized microwaves at a frequency of 60.125 GHz.…”

Section: Introductionmentioning

confidence: 99%

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Non-thermal Influence of A Weak Microwave on Nerve Fiber Activity

MN¹

2014

J Phys Chem Biophys

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This paper presents a short selective review of the non-thermal weak microwave field impact on a nerve fiber. The published results of recent experiments are reviewed and analyzed. The theory of the authors is presented, according to which there are strongly pronounced resonances in the range of about 30-300 GHz associated with the excitation of ultrasonic vibrations in the membrane as a result of interactions with the microwave radiation. These forced vibrations create acoustic pressure, which may lead to the redistribution of the protein transmembrane channels, thus changing the threshold of the action potential excitation in the axons of the neural network. Тhe problem of surface charge on the bilayer lipid membrane of the nerve fiber is discussed. Various experiments for observing the effects considered are also discussed.

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Modulation of Voltage‐Gated Ion Channels by Sialylation

Ednie

Bennett

2012

Comprehensive Physiology

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Control and modulation of electrical signaling is vital to normal physiology, particularly in neurons, cardiac myocytes, and skeletal muscle. The orchestrated activities of variable sets of ion channels and transporters, including voltage‐gated ion channels (VGICs), are responsible for initiation, conduction, and termination of the action potential (AP) in excitable cells. Slight changes in VGIC activity can lead to severe pathologies including arrhythmias, epilepsies, and paralyses, while normal excitability depends on the precise tuning of the AP waveform. VGICs are heavily posttranslationally modified, with upward of 30% of the mature channel mass consisting of N‐ and O‐glycans. These glycans are terminated typically by negatively charged sialic acid residues that modulate voltage‐dependent channel gating directly. The data indicate that sialic acids alter VGIC activity in isoform‐specific manners, dependent in part, on the number/location of channel sialic acids attached to the pore‐forming alpha and/or auxiliary subunits that often act through saturating electrostatic mechanisms. Additionally, cell‐specific regulation of sialylation can affect VGIC gating distinctly. Thus, channel sialylation is likely regulated through two mechanisms that together contribute to a dynamic spectrum of possible gating motifs: a subunit‐specific mechanism and regulated (aberrant) changes in the ability of the cell to glycosylate. Recent studies showed that neuronal and cardiac excitability is modulated through regulated changes in voltage‐gated Na + channel sialylation, suggesting that both mechanisms of differential VGIC sialylation contribute to electrical signaling in the brain and heart. Together, the data provide insight into an important and novel paradigm involved in the control and modulation of electrical signaling. © 2012 American Physiological Society. Compr Physiol 2:1269‐1301, 2012.

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Estimation of surface charges in some biological membranes

Cited by 23 publications

References 29 publications

Thermal Transients Excite Neurons through Universal Intramembrane Mechanoelectrical Effects

Thermal Transients Excite Neurons through Universal Intramembrane Mechanoelectrical Effects

Non-thermal Influence of A Weak Microwave on Nerve Fiber Activity

Modulation of Voltage‐Gated Ion Channels by Sialylation

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