Estimation of T-helper 1 Cytokines (IFN-y and TL-2) in HBV Infected patients and Individuals vaccinated with Recombinant HB Vaccine

Al-Barzinji, Rukia M.; Ahmed, Hiwa Abdul Rahman

doi:10.15218/zjms.2009.019

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Therefore, circulating GM-CSF levels may correlate with the degree of liver fibrosis and systemic inflammation in CLD of different etiologies including HCV infection and NASH. Moreover, our findings are in agreement with Al-Barzinji and Ahmed [29] who demonstrated significant increase in GM-CSF levels in patients in the acute phase of hepatitis compared to those with chronic hepatitis and control subjects. Our findings also revealed a progressive increase in GM-CSF levels which match the severity of the disease and the stage of liver fibrosis.…”

Section: Discussionsupporting

confidence: 93%

Role of Circulating Hematopoietic Fibrocytes in Chronic Hepatitis C Patients Induced Liver Fibrosis

El-Bassiouni

Amin²,

Rizk³

et al. 2022

Open Access Maced J Med Sci

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Background: Bone marrow derived fibrocytes may play an important role in pathogenesis and resolution of liver fibrosis. These cells may offer new approaches for better understanding the pathogenesis of liver fibrosis. Aim of the work: To define the proportion of circulating fibrocytes with hematopoietic progenitor origin as defined by CD45 and CD34 positivity and to assess whether they are increased in patients with chronic C hepatitis in correlation to the degree of liver fibrosis. Subjects and Methods: Sixty HCV patients were classified according to METAVIR score into 4 stages of liver fibrosis, 15 age and sex-matched controls were included. Flowcytometric analysis for circulating levels of fibrocytes CD34+ve cells, CD45+ve cells, collagen type I+ve cells and CXCR4+ve cells was carried out using monoclonal antibodies (anti-CD34, CD45, collagen type I and CD184). GM-CSF, TGF-β and α-SMA were assessed using ELISA. Results and Conclusions: A significant increase in the circulating levels of GM-CSF, TGF- β and α-SMA, with a significant increase in the percentage of cells express CXCR4and in the co expression of CD34, CD45 and collagen type I positive cells in different groups of patients compared to control group, denoting the presence of an increased proportion of circulating fibrocytes in peripheral blood of these patients. The percentage of fibrocytes that positively expression CD34, CD45, collagen type I and CXCR4, were increased in step wise fashion in conjunction with worsening severity of liver disease. Liver fibrosis is associated with increased levels of circulating TGF-β1 and lipopolysaccharide, activation of myofibroblasts, and extensive deposition of extracellular matrix, mostly collagen Type I. TGF-β and LPS play a critical role in fibrogenesis and trigger fibrocyte recruitment to the injured liver promoting their differentiation into collagen type I producing myofibroblast, supporting that fibrocytes may become a novel target for anti fibrotic therapy.

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Section: Discussionsupporting

confidence: 93%

Role of Circulating Hematopoietic Fibrocytes in Chronic Hepatitis C Patients Induced Liver Fibrosis

El-Bassiouni

Amin²,

Rizk³

et al. 2022

Open Access Maced J Med Sci

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“…Moreover, Muller et al (1994) exhibited that mice IFNAR lacking are more vulnerable to viral infections , such as vesicular stomatitis virus (VSV). Besides, another investigation reported that when HBV infection, IFN-γ, and IL-2 are elevated significantly in the patient's serum decided that IFN-γ is required for host antiviral immunity against HBV infection, while "IL-4 and IL-10 which are secreted by T helper-2 cells are associated in the humoral immunity Al-Barzinji, 2009, Ahmed andAl-Barzinji, 2011). ORF 6 protein of SARS-CoV suppresses IFN type 1 production via inhibition of IFN-induced JAK-STAT signaling and preventing the nuclear translocation of phosphorylated STAT1 and consequently hide from innate immunity response" (Perlman and Netland, 2009.…”

Section: Type ⅰ Interferonsmentioning

confidence: 99%

Mechanism of Innate Immune Responses Against SARS-COV-2 Infection

2023

ZJPAS

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The immunopathogenesis of Coronaviruses (CoVs) is still under study. The innate immunity components can differentiate self and non-self-antigens, help viral particle recognition, and restrict viral replication by producing antiviral proteins. Induction of antiviral innate immune responses against SARS CoV-2 commonly depends on recognizing pathogen-associated molecular pattern molecules (PAMPs) by pattern recognition receptors (PRRs). PAMPs mount the activation of Toll-Like Receptors (TLR) cascade and initiate transcription factors, involving Nuclear Factor-κB (NF-Κb), Interferon Regulatory Factors (IRF3), and (IRF7), which results in the synthesize of Interferons (IFN) type I Subsequently, type I IFN inhibits viral replications, regulates, and modulates the immune system. Dendritic cells (DCs) reside in the respiratory tract. They can recognize viral particles via TLR and initiate innate and adaptive immunity and repress viral spreads through IFN production. barrier of TLR, impediment of IFN expression, and/or lack of innate immune responses may be associated with tissue destruction after viral elimination. Here, emerging the reviews knowledge on the mechanism of non-specific immune responses against SARS-COV-2.

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Estimation of T-helper 1 Cytokines (IFN-y and TL-2) in HBV Infected patients and Individuals vaccinated with Recombinant HB Vaccine

Cited by 2 publications

References 11 publications

Role of Circulating Hematopoietic Fibrocytes in Chronic Hepatitis C Patients Induced Liver Fibrosis

Role of Circulating Hematopoietic Fibrocytes in Chronic Hepatitis C Patients Induced Liver Fibrosis

Mechanism of Innate Immune Responses Against SARS-COV-2 Infection

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