Estimation of Telmisartan, Amlodipine and Chlorthalidone in Bulk and Fixed Dose Combination Using Stability Indicating High Performance Thin Layer Chromatography

Chaudhary, Bhamini R.; Dave, J. B.

doi:10.35652/igjps.2020.10302

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…The mobile phase employed was Chloroform: Toluene: Methanol: Glacial Acetic Acid (6:2:2:0.1 % v/v/v/v). Exceptional linearity was achieved for all the three analytes with the detector wavelength at 254 nm [34] .…”

Section: Other Amlodipine Besylate Combinationsmentioning

confidence: 94%

A Review on Simultaneous Determination of Anti-Hypertensive Drug Combinations Containing Amlodipine Besylate using Chromatographic Analysis

Chandran¹

2022

Asian J Pharm Res Dev

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The present review aims to investigate some of the recently reported analytical methods available for the assay ofantihypertensive drugs in various combinations of pharmaceutical forms. Several simultaneous RP- HPLC methods have beenreported for the determination of antihypertensive drugs. The review familiarizes various reported methods for the simultaneousdetermination of Amlodipine besylate with other antihypertensive drug formulations which are used in combination treatmentprotocols.

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Section: Other Amlodipine Besylate Combinationsmentioning

confidence: 94%

A Review on Simultaneous Determination of Anti-Hypertensive Drug Combinations Containing Amlodipine Besylate using Chromatographic Analysis

Chandran¹

2022

Asian J Pharm Res Dev

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“…e literature reported few analysis methods for quantification of CTL and AZE alone and in combination with other antihypertensive drugs. Several spectrophotometric methods [8][9][10][11][12][13][14], spectrofluorometric methods [8,13], HPLC [14][15][16], and HPTLC [17] methods were carried out for the estimation of CTL and AZE with other analytes in the formulations. Stability indicating RP-HPLC methods [18][19][20][21][22] were also reported in the literature for quantification of CTL and AZE separately.…”

Section: Introductionmentioning

confidence: 99%

Mathematically Processed UV Spectroscopic Method for Quantification of Chlorthalidone and Azelnidipine in Bulk and Formulation: Evaluation of Greenness and Whiteness

Attimarad

Chohan

Narayanaswamy

et al. 2022

Journal of Spectroscopy

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A simple, eco-friendly four analytical methods were established by improving the selectivity through the application of mathematical processing of UV absorption spectra for concurrent quantification of chlorthalidone (CTL) and azelnidipine (AZE). The UV absorption spectra were recorded using environment-friendly ethanol (10% v/v) and were mathematically processed using simple software provided with a UV spectrophotometer. The analytes’ peak amplitude was determined using zero-crossing point first derivative spectra and ratio first derivative spectra of CTL and AZE, which were measured at 238.5 nm and 239.5 nm for CTL and 272.1 nm and 342.1 nm for AZE, respectively. The peak amplitude difference was determined from the ratio spectra of CTL and AZE by measuring the peak amplitudes at 211.8 and 267.2 nm for CTL and 328.4 and 286.1 nm for AZE. Further, ratio spectra of CTL and AZE were converted into zero-order spectra by subtracting the constant followed by multiplication with divisor spectra, and the peak amplitudes were measured at 226.9 nm and 257.3 nm for CTL and AZE zero-order spectra, respectively. Further, validation results of all the four methods confirmed the accuracy and precision of the methods by displaying good recovery (98.37–100.34%) and percentage relative standard deviation (0.397–1.758%), respectively. Good linearity was observed in the range of 1–15 μg/mL for both analytes with less than a 1 μg/mL limit of quantification. Further, the greenness and whiteness of the methods were evaluated by recently proposed AGREEness, complexGAPI, and white analytical chemistry techniques. The proposed UV spectroscopic methods were environmentally friendly, safe, economic, and effective, hence, could be used for regular quality control study of a formulation containing CTL and AZE.

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Box‒Behnken design-assisted development of an eco-friendly thin-layer chromatography‒densitometry method for the quantification of amlodipine besylate, metoprolol succinate, and telmisartan in synthetic mixture using AGREE tool

Patel,

Macwan,

Prajapati

et al. 2023

JPC-J Planar Chromat

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Estimation of Telmisartan, Amlodipine and Chlorthalidone in Bulk and Fixed Dose Combination Using Stability Indicating High Performance Thin Layer Chromatography

Cited by 5 publications

References 16 publications

A Review on Simultaneous Determination of Anti-Hypertensive Drug Combinations Containing Amlodipine Besylate using Chromatographic Analysis

A Review on Simultaneous Determination of Anti-Hypertensive Drug Combinations Containing Amlodipine Besylate using Chromatographic Analysis

Mathematically Processed UV Spectroscopic Method for Quantification of Chlorthalidone and Azelnidipine in Bulk and Formulation: Evaluation of Greenness and Whiteness

Box‒Behnken design-assisted development of an eco-friendly thin-layer chromatography‒densitometry method for the quantification of amlodipine besylate, metoprolol succinate, and telmisartan in synthetic mixture using AGREE tool

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