Estimation of the Cure Rate in Iranian Breast Cancer Patients

Rahimzadeh, Mitra; Baghestani, Ahmad Reza; Gohari, Mahmood Reza; Pourhoseingholi, Mohamad Amin

doi:10.7314/apjcp.2014.15.12.4839

Cited by 39 publications

(39 citation statements)

References 21 publications

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“…Breast cancer is growing strongly in South America, Africa and Asia.Studies show that early detection of breast cancer has an important role in reducing the mortality rate and improving the prognosis of the disease (Rahimzadeh et al, 2014). In developed countries, more than 50 percent of eligible women are being screened but in these countries, immigrant women and the ones who have low economic status are being deprived of screening (Vahabi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Incidence and Mortality and Epidemiology of Breast Cancer in the World

Ghoncheh¹,

Pournamdar²,

Salehiniya³

2016

Asian Pacific Journal of Cancer Prevention

962

635

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Section: Introductionmentioning

confidence: 99%

Incidence and Mortality and Epidemiology of Breast Cancer in the World

Ghoncheh¹,

Pournamdar²,

Salehiniya³

2016

Asian Pacific Journal of Cancer Prevention

962

635

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“…Early detection of BC plays a major role in reducing mortality and improving patients' prognosis among women (Elmore et al, 2005;Hoerger et al, 2011). So in some cancers, such as BC, long-term survival is expected to occur (Rahimzadeh et al, 2013). Paying attention to the cancer as a health priority at national and regional levels is among the requirements of the health system.…”

Section: Introductionmentioning

confidence: 99%

Spatial Analysis of Breast Cancer Incidence in Iran

Mahdavifar¹,

Pakzad²,

Ghoncheh³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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of oncology death in women in these countries (Jemal et al., 2011). BC comprises about one-fifth of all female cancers. This cancer is the cause of deaths in high-income countries and the second cause of death in low and middle income countries (Payandeh et al., 2015b). BC is the most common cause of death in middle-aged women AbstractBreast cancer (BC) is the most common cancer in females (27% of the total) and the main cause of death (16%) due to cancer in women in developed and developing countries. Variations in its incidence rate among geographical areas are due to various contributing factors. Since there have been a lack of studies on this topic in our country, the present spatial analysis of breast cancer incidence in Iran in 2009 was conducted using data from the national cancer registry system. The reported incidences of the disease were standardized according to the World Health Organization population and the direct method. Then data was inserted into the GIS software and finally, using the Hot Spot Analysis (Geties-Ord Gi), high-risk areas were drawn. Provinces with incidences 1.96 SD higher or lower than the national average were considered as hot spots or cold spots, at the significance level of 0.05%. In 2009, a total of 7,582 cases of BC occurred in Iran. The annual incidence was 33.2 per hundred thousand people. Our study showed that the highest incidence of BC in women occurred in the central provinces of the country, Tehran, Isfahan, Yazd, Markazi and Fars. The results of hot spots analysis showed that the distribution of high-risk BC was focused in central parts of Iran, especially Isfahan province (p <0.01). The other provinces were not significantly different from the national average. The higher incidence in central provinces may be due to greater exposure to carcinogens in urban areas, a Western lifestyle and high prevalence of other risk factors. Further epidemiological studies about the etiology and early detection of BC are essential.

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“…In Iran, it is also the most common cancer among women (Rahimzadeh et al, 2014). A number factors such as menopausal states and genetic variants can extend the risk of malignancy (Rai, 2014).…”

Section: Introductionmentioning

confidence: 99%

Association of rs1219648 in FGFR2 and rs1042522 in TP53 with Premenopausal Breast Cancer in an Iranian Azeri Population

Saadatian¹,

Gharesouran²,

Ghojazadeh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Breast cancer is the most common cancer among women in the world. In Iran, the incidence of breast cancer is on the increase. We here studied the association of rs1219648 in FGFR2 and rs1042522 in TP53 and their interaction in development of early onset sporadic breast cancer in Iranian Azeri population to evaluate epistatic effects on the risk of mammary neoplasia. We genotyped the two polymorphisms in 100 women with early onset breast cancer and 100 healthy women by PCR-RFLP. Allele frequency differences were tested using chi 2 -test with 95% confident intervals. Our results indicated a statistically significant association (p<0.05) between rs1219648, but not rs1042522, and risk of breast cancer. We also found that the combination of FGFR2 major genotype and TP53 hetero genotype had protective effects against breast cancer , while the hetero allele of FGFR2 in combination with the minor genotype of TP53 was associated with a high risk. This study revealed an important crosstalk between two polymorphisms in FGFR2 and TP53 in development of breast cancer. These candidates risk variants should be further evaluated in studies with a larger sample size.

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Estimation of the Cure Rate in Iranian Breast Cancer Patients

Cited by 39 publications

References 21 publications

Incidence and Mortality and Epidemiology of Breast Cancer in the World

Incidence and Mortality and Epidemiology of Breast Cancer in the World

Spatial Analysis of Breast Cancer Incidence in Iran

Association of rs1219648 in FGFR2 and rs1042522 in TP53 with Premenopausal Breast Cancer in an Iranian Azeri Population

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