Estimation of the Effect of the Course of Short-Term Sessions of Dry Immersion on Autonomic Regulation in Patients with Parkinsonism

Gerasimova-Meigal, Liudmila; Sireneva, Nadezhda; Meigal, Alexander

doi:10.1134/s0362119721040046

Cited by 2 publications

(7 citation statements)

References 19 publications

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“…In turn, it indicates reduced mechanisms of neuroplasticity in PD. Similarly, in our earlier study, we have demonstrated no HRV dynamics seen with cardiovascular tests during the program of DI (Gerasimova- Meigal et al, 2021). Such results accord with the study of Rocha et al (2018) in which a program of game-based rehabilitation in PD presented no modification of HRV.…”

Section: Hrv During the Program Of DI Sessionssupporting

confidence: 90%

“…We assume that such inputs could be associated with BRS and, emerging cardiorespiratory coupling, therefore, increased parasympathetic and sympathetic nervous control of HRV. A similar phenomenon of stronger cardiorespiratory coupling we reported in our earlier study with a deep breathing test (Gerasimova-Meigal et al, 2021). Altogether, the HRV of PD subjects after a 45-min DI session has clearly shifted in the direction of "normal" agematched values.…”

Section: Hrv During a Single One DI Sessionsupporting

confidence: 88%

“…However, this result was obtained after much longer DI sessions (3-21 days). In subjects with PD, BRS is substantially decreased, which is associated with orthostatic hypotension (Blaho et al, 2017;Gerasimova-Meigal et al, 2021), arterial stiffness, presence of central α-synuclein aggregation, cardiac sympathetic denervation, attenuated muscle sympathetic nerve activity (Sabino-Carvalho et al, 2021). In our study, none of the subjects with PD had signs of orthostatic hypotension what was earlier reported in the study by Gerasimova-Meigal et al (2021).…”

Section: Baroreceptor Reflex Sensitivitysupporting

confidence: 67%

“…Also, the correlation between HR and HRV indices of parasympathetic activity (SDNN, RMSSD, pNN50, TP, HF, and SD1) was negative, which is consistent with consensus on autonomic control of the cardiovascular system (Heart rate variability, 1996; Shaffer and Ginsberg, 2017). The negative correlation between hemodynamic parameters and HRV indices of sympathetic activity (LF and SD2) did not fit this consensus, probably due to impaired sympathetic control and baroreflex sensitivity, which is often observed in PD patients (Blaho et al, 2017;Gerasimova-Meigal et al, 2021). By contrast, under the conditions of DI significant correlations appeared between HRV parameters and systolic BP, which evidenced the temporal emergence of causal coupling between BP and HR.…”

Section: Correlation Between Bp Hr and Hrvsupporting

confidence: 62%

“…Before the program of DI sessions, all PD subjects were examined with an active orthostatic test for orthostatic tolerance. In none of the subjects, orthostatic hypotension was found (Gerasimova- Meigal et al, 2021).…”

Section: Participantsmentioning

confidence: 99%

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Autonomic Function in Parkinson's Disease Subjects Across Repeated Short-Term Dry Immersion: Evidence From Linear and Non-linear HRV Parameters

et al. 2021

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Several studies have shown that “dry” immersion appears as a promising method of rehabilitation for Parkinson's disease. Still, little is known about the cardiovascular reaction in “dry” immersion (DI), especially in Parkinson's disease (PD). Therefore, this study was aimed to evaluate the effect of repeated 45-min DI sessions on autonomic function in subjects with PD. The study group consisted of 20 subjects with PD [13 men, seven women, aged 51–66 years old, Hoehn & Yahr (H&Y) staged 1–3] were enrolled in the study according to inclusion and non-inclusion criteria. The DI program was comprised of seven 45-min DI sessions, applied within 25–30 days. Blood pressure (BP), heart rate (HR), and electrocardiogram (ECG) in the standard lead II were recorded at 1st, 4th, and 7th DI, before, on the 15, 30, and 40th min of DI session. Autonomic function was assessed with analysis of heart rate variability (HRV) using Kubios Standard version 2 software. Linear (time- and frequency-domain) and non-linear (correlation dimension, entropies, DFA1 and DFA2, percent of determinism, and recurrence) were computed. At baseline condition, time- and frequency-domain HRV parameters showed low variability of HR, which indicates reduced autonomic neurogenic control of HR. Throughout the DI session, systolic and diastolic BP has decreased by 5–7 mm Hg (p < 0.001), and time- and frequency-domain parameters of HRV have significantly increased, what can be regarded as compensatory mechanisms of hemodynamics during DI. The structure of the regulatory input to the heart seen by HRV was characterized by low complexity and reduced autonomic neurogenic control of HR. Across the program of DI sessions, the hypotensive effect was documented, but no notable modification of the HRV-parameters was found. The absence of long-term modification of the studied parameters can be attributed both to deconditioning environmental effect of DI and limited adaptation of the organism due to neurodegeneration in PD. That should be taken into consideration when planning rehabilitation measures in subjects of older age and chronic somatic diseases with modeled microgravity.

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Section: Hrv During the Program Of DI Sessionssupporting

confidence: 90%

Section: Hrv During a Single One DI Sessionsupporting

confidence: 88%

Section: Baroreceptor Reflex Sensitivitysupporting

confidence: 67%

Section: Correlation Between Bp Hr and Hrvsupporting

confidence: 62%

Section: Participantsmentioning

confidence: 99%

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Autonomic Function in Parkinson's Disease Subjects Across Repeated Short-Term Dry Immersion: Evidence From Linear and Non-linear HRV Parameters

et al. 2021

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Cerebral Circulation and Brain Temperature during an Ultra-Short Session of Dry Immersion in Young Subjects

Gerasimova-Meigal,

Meigal,

Gerasimova

et al. 2023

Pathophysiology

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The primary aim of the study was to assess cerebral circulation in healthy young subjects during an ultra-short (45 min) session of ground-based microgravity modeled by “dry” immersion (DI), with the help of a multifunctional Laser Doppler Flowmetry (LDF) analyzer. In addition, we tested a hypothesis that cerebral temperature would grow during a DI session. The supraorbital area of the forehead and forearm area were tested before, within, and after a DI session. Average perfusion, five oscillation ranges of the LDF spectrum, and brain temperature were assessed. Within a DI session, in the supraorbital area most of LDF parameters remained unchanged except for a 30% increase in respiratory associated (venular) rhythm. The temperature of the supraorbital area increased by up to 38.5 °C within the DI session. In the forearm area, the average value of perfusion and its nutritive component increased, presumably due to thermoregulation. In conclusion, the results suggest that a 45 min DI session does not exert a substantial effect on cerebral blood perfusion and systemic hemodynamics in young healthy subjects. Moderate signs of venous stasis were observed, and brain temperature increased during a DI session. These findings must be thoroughly validated in future studies because elevated brain temperature during a DI session can contribute to some reactions to DI.

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Estimation of the Effect of the Course of Short-Term Sessions of Dry Immersion on Autonomic Regulation in Patients with Parkinsonism

Cited by 2 publications

References 19 publications

Autonomic Function in Parkinson's Disease Subjects Across Repeated Short-Term Dry Immersion: Evidence From Linear and Non-linear HRV Parameters

Autonomic Function in Parkinson's Disease Subjects Across Repeated Short-Term Dry Immersion: Evidence From Linear and Non-linear HRV Parameters

Cerebral Circulation and Brain Temperature during an Ultra-Short Session of Dry Immersion in Young Subjects

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