Estimation of the Phospholipid Phosphorus Turnover Time in Man: Studies in Normal Individuals, in Patients With the Nephrotic Syndrome and in Other Types of Hyperlipemia 1

Moser, Hugo W.; Emerson, Kendall

doi:10.1172/jci103175

Cited by 20 publications

(3 citation statements)

References 16 publications

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“…was a likely candidate because a) it is present in arterial plasma in such quantities that extraction of only 25 per cent of arterial FFA would furnish the missing substrate for the observed 02 uptake of muscle; b) circulating FFA is known to turn over with extraordinary rapidity, its half-life in plasma being about 2 minutes (2, 3); c) other lipid fractions disappear from the plasma of eviscerated animals only very slowly (4,5).…”

mentioning

confidence: 99%

Heterogeneity of Forearm Metabolism With Special Reference to Free Fatty Acids*

Baltzan¹,

Andres²,

Cader³

et al. 1962

J. Clin. Invest.

159

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The metabolism of the forearm of man has been appraised by application of the Fick principle (1). The data were interpreted as indicative of the metabolism of skeletal muscle, because some two-thirds of the bulk of the forearm is skeletal muscle and because approximately 85 per cent of forearm blood flow perfuses skeletal muscle. These data on 14 subjects showed that resting skeletal muscle of the forearm, with the subject in the basal state, consumed oxygen vigorously and that only 7 + 71 per cent of its 02 uptake could be accounted for by oxidation of glucose abstracted from arterial blood. Because forearm respiratory quotient was 0.80 ± 0.03 it was concluded that the major substrate for oxygen consumption by forearm muscles was lipid. Additional subjects have now been studied and a summary of this more extensive experience is as follows: 16 + 5 per cent of 02 uptake can be accounted for by glucose oxidation (43 subjects), and forearm R.Q. is 0.76 ± 0.02 (45 subjects). The missing substrate(s) for oxidation can be calculated to be substances which on oxidation give an R.Q. of 0.71.It was predicted that the plasma lipid fraction oxidized by muscle would prove to be that fraction of fatty acid transported in intimate association with serum albumin, variously called free fatty acid (FFA), unesterified fatty acids (UFA), or nonesterified fatty acids (NEFA). This fraction *These studies were aided by Contract Nonr-248 (34) between the Office of Naval Research, Department of the Navy, and The Johns Hopkins University; and by grants-in-aid from the National Institutes of Health, Department of Health, Education, and Welfare (A-750); and the Muscular Dystrophy Associations of America, Inc. Reproduction in whole or in part is permitted for any purpose of the United States Government.1 These data and similarly expressed data throughout the paper will always refer to the mean + the standard error of the mean. was a likely candidate because a) it is present in arterial plasma in such quantities that extraction of only 25 per cent of arterial FFA would furnish the missing substrate for the observed 02 uptake of muscle; b) circulating FFA is known to turn over with extraordinary rapidity, its half-life in plasma being about 2 minutes (2, 3); c) other lipid fractions disappear from the plasma of eviscerated animals only very slowly (4, 5).Over a period of 6 years we have failed to obtain direct evidence that this prediction is true.The discrepancy between what seemed likely to be an unimpeachable prediction and valid experimental observation led us to re-examine the basic assumptions which we had applied to study of the forearm of man and to consider the heterogeneity of the forearm tissues and the complexity of its venous drainage.It is the purpose of this report to present data on the differences in concentration of various metabolites between superficial and deep venous blood from the forearm of man, to verify the metabolic heterogeneity of the forearm, to report the concentrations of FFA in arterial, deep venous and supe...

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mentioning

confidence: 99%

Heterogeneity of Forearm Metabolism With Special Reference to Free Fatty Acids*

Baltzan¹,

Andres²,

Cader³

et al. 1962

J. Clin. Invest.

159

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“…These conclusions agree with those drawn from previous work. Zilversmit, et al, (20) in dogs, and Moser and Emerson (21) in man, derived precursor-product relationships between liver inorganic phosphate and glycerophosphate and liver phospholipids, and urine phosphate and plasma phospholipids, respectively. Although these experiments, in which the technique developed by Zilversmit, et al, (22) was used, suggest that no large poorly labeled pools of inorganic phosphate or phospholipid supply the pool of serum phospholipid, the complexities of phospholipid metabolism are such that calculation of turnover times is likely to be of limited validity.…”

Section: Discussionmentioning

confidence: 99%

Slow exchange of erythrocyte and plasma phospholipids

Calvert¹,

Scott

1974

Lipids

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“…Data on the phosphatides in this condition have been limited to alterations in the levels of the lipid phosphorus in the plasma and in the lipoprotein classes (7), and to changes in the incorporation of P32 into the lipid phosphorus of plasma (8). A change in the composition of the plasma phosphatides has been postulated on the basis of these p32 experiments.…”

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confidence: 99%